Information
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Patent Application
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20070191355
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Publication Number
20070191355
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Date Filed
February 15, 200717 years ago
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Date Published
August 16, 200717 years ago
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Inventors
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Original Assignees
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CPC
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US Classifications
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International Classifications
Abstract
The invention provides 8-azabicyclo[3.2.1 ]octyl intermediates useful for the preparation of 5-HT4 receptor agonist compounds. The invention also provides processes for the preparation of such useful intermediates.
Claims
- 1. A compound of formula (I):
- 2. The compound of claim 1 wherein n is 0 and R1 is hydrogen.
- 3. The compound of claim 1 wherein n is 1 and R1 is —OH or —OP1.
- 4. The compound of claim 1 wherein A is a covalent bond.
- 5. The compound of claim 1 wherein W is a moiety of formula (a).
- 6. The compound of claim 5 wherein Z is selected from NC(O)R4, NS(O)2R6, and S(O)2 and R4 and R6 are each methyl.
- 7. The compound of claim 5 wherein Z is NH.
- 8. The compound of claim 1 wherein W is —N(R3)C(O)R4, or —N(R5)S(O)2R6.
- 9. A process for preparing a compound of formula (Ib) or a salt thereof:
- 10. The process of claim 9 wherein the buffering agent is present in an amount sufficient to maintain the pH of the reaction mixture between about 4 and about 6.
- 11. A process for preparing a compound of formula (Ia) or a salt thereof:
- 12. The process of claim 11 wherein the process comprises step (a).
- 13. The process of claim 12, wherein the product of formula (Ia) has an endo to exo ratio of greater than 99:1.
Provisional Applications (1)
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Number |
Date |
Country |
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60774066 |
Feb 2006 |
US |