Process for preparing intermediates to 5-HT4 receptor agonist compounds

Information

  • Patent Application
  • 20070191355
  • Publication Number
    20070191355
  • Date Filed
    February 15, 2007
    17 years ago
  • Date Published
    August 16, 2007
    17 years ago
Abstract
The invention provides 8-azabicyclo[3.2.1 ]octyl intermediates useful for the preparation of 5-HT4 receptor agonist compounds. The invention also provides processes for the preparation of such useful intermediates.
Description
Claims
  • 1. A compound of formula (I):
  • 2. The compound of claim 1 wherein n is 0 and R1 is hydrogen.
  • 3. The compound of claim 1 wherein n is 1 and R1 is —OH or —OP1.
  • 4. The compound of claim 1 wherein A is a covalent bond.
  • 5. The compound of claim 1 wherein W is a moiety of formula (a).
  • 6. The compound of claim 5 wherein Z is selected from NC(O)R4, NS(O)2R6, and S(O)2 and R4 and R6 are each methyl.
  • 7. The compound of claim 5 wherein Z is NH.
  • 8. The compound of claim 1 wherein W is —N(R3)C(O)R4, or —N(R5)S(O)2R6.
  • 9. A process for preparing a compound of formula (Ib) or a salt thereof:
  • 10. The process of claim 9 wherein the buffering agent is present in an amount sufficient to maintain the pH of the reaction mixture between about 4 and about 6.
  • 11. A process for preparing a compound of formula (Ia) or a salt thereof:
  • 12. The process of claim 11 wherein the process comprises step (a).
  • 13. The process of claim 12, wherein the product of formula (Ia) has an endo to exo ratio of greater than 99:1.
Provisional Applications (1)
Number Date Country
60774066 Feb 2006 US