Claims
- 1. A through process for preparing methylvanillyl ketone which comprises:
- (1) direct oxidation of an unprotected isoeugenol in an aqueous solution of an organic acid to obtain a reaction mixture containing unprotected isoeugenol glycol as an intermediate therein; said organic acid being selected from the group consisting of formic acid, acetic acid, propionic acid, trichloroacetic acid, or trifluoroacetic acid;
- (2) heating said reaction mixture at a temperature of about 25.degree.-100.degree. C. with an aqueous solution of a strong acid in an inert solvent; said strong acid being selected from the group consisting of sulfuric acid, alkyl or aryl sulfonic acid, hydrobromic acid, hydrochloric acid, or phosphoric acid; and,
- (3) recovering methylvanillyl ketone directly from said acid-treated reaction mixture without isolating said unprotected isoeugenol glycol intermediate.
- 2. The process of claim 1 wherein said oxidation reagent is a member of the group consisting of peroxide or peracid; and, said inert solvent is a member of the group consisting of benzene, toluene, or xylene.
- 3. The process of claim 2 wherein said peroxide is hydrogen peroxide or disuccinoyl peroxide; said peracid is performic acid, peracetic acid, peroxytrifluoroacetic acid, monopersuccinic acid, m-chlorobenzoic acid, p-methoxycarbonylperbenzoic acid, o-sulfoperbenzoic acid, or monoperphthalic acid; and, said heating is at a temperature of about 30.degree.-60.degree. C.
- 4. The process of claim 3 wherein said peroxide is hydrogen peroxide; said peracid is peracetic acid; and, said organic acid is formic acid or acetic acid.
- 5. The process of claim 4 wherein said peroxide is hydrogen peroxide; said organic acid is formic acid; said heating is at a temperature of about 35.degree.-40.degree. C.; said strong acid is sulfuric acid; and, said inert solvent is toluene.
- 6. The process of claim 5 wherein said sulfuric acid and said toluene are present in said reaction mixture in an amount of about 10-20%; and said heating is at the reflux temperature of said reaction mixture.
Parent Case Info
This application is a divisional application of pending application Ser. No. 079,748 filed Sept. 28, 1979, now U.S. Pat. No. 4,337,360.
Non-Patent Literature Citations (2)
Entry |
Kulka et al, J.A.C.S., vol. 65, p. 1184, (1943). |
Freudenberg et al, Chem. Ber., vol. 76, pp. 1005-1006, (1943). |
Divisions (1)
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Number |
Date |
Country |
Parent |
79748 |
Sep 1979 |
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