TREA

PROCESS FOR PREPARING N-(2-CHLORO-6-METHYLPHENYL)-2-[[6-[4-(2-HYDROXYETHYL)-1-PIPERAZINYL]-2-METHYL-4-PYRIMIDINYL]AMINO] -5-THIAZOLECARBOXAMIDE AND RELATED METABOLITES THEREOF

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Information

  • Patent Application
  • 20070219370
  • Publication Number
    20070219370
  • Date Filed
    March 14, 2007
    17 years ago
  • Date Published
    September 20, 2007
    16 years ago
Information
Abstract
The present invention is directed to process for the preparation of metabolites as well as the parent compound of N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl] amino]-5-thiazolecarboxamide, the compound of formula (I).
Description
Claims
  • 1. A process for preparing a compound of formula (Ia)
  • 2. A process for preparing a compound of formula (IIa),
  • 3. The process of claim 2, wherein the compound of formula IIa has the formula (IIa′)
  • 4. The process of claim 2, wherein
  • 5. The process of claim 4, wherein
  • 6. The process of claim 4, wherein
  • 7. The process of claim 4, wherein
  • 8. The process of claim 4, wherein
  • 9. The process of claim 2, wherein the compound of formula IIa has the formula IV
  • 10. The process of claim 1, wherein
  • 11. The process of claim 1, wherein Ra is selected from hydrogen alkyl, halo, hydroxyalkyl, C(O)OH, C(O)O-alkyl, alkyl-OC(O)—R1.
  • 12. The process of claim 2, wherein
Provisional Applications (1)
Number Date Country
60782622 Mar 2006 US