Claims
- 1. A process for preparing a compound of the formula (I) ##STR7## in which R.sub.1 is hydrogen, C.sub.1 -C.sub.8 alkyl, C.sub.7 -C.sub.9 phenylalkyl which is unsubstituted or mono-, di- or tri-substituted on the phenyl by C.sub.1 -C.sub.4 alkyl; or C.sub.1 -C.sub.8 acyl, R.sub.2 is C.sub.2 -C.sub.12 alkylene, C.sub.4 -C.sub.12 alkylene interrupted by 1, 2 or 3 oxygen atoms or by 1, 2 or 3>N--COOR.sub.3 or >N--CH.sub.3 groups; C.sub.5 -C.sub.7 cycloalkylene which is unsubstituted or monosubstituted by C.sub.1 -C.sub.4 alkyl; C.sub.5 -C.sub.7 cycloalkylenedi(C.sub.1 -C.sub.4 alkylene), C.sub.1 -C.sub.4 alkylenedi(C.sub.5 C.sub.7 cycloalkylene), phenylenedi(C.sub.1 -C.sub.4 alkylene), or (C.sub.1 -C.sub.4 alkylene)diphenylene and R.sub.3 is C.sub.1 -C.sub.18 alkyl, C.sub.3 -C.sub.18 alkyl interrupted by 1 or 2 oxygen atoms; C.sub.5 -C.sub.2 cycloalkyl which is unsubstituted or mono-, di- or tri-substituted by C.sub.1 -C.sub.4 alkyl; C.sub.3 - C.sub.18 alkenyl, phenyl which is unsubstituted or mono-, di- or tri-substituted by C.sub.1 -C.sub.4 alkyl or by C.sub.1 -C.sub.4 alkoxy; C.sub.7 -C.sub.9 phenylalkyl which is unsubstituted or mono-, di- or tri-substituted on the phenyl by C.sub.1 -C.sub.4 alkyl;
- which process comprises reacting, in water, in the absence of an organic solvent, a compound of the formula (II)
- Cl--COOR.sub.3 (II)
- wherein R.sub.3 is as defined above with a compound of the formula (III) ##STR8## where R.sub.1 is as defined above and R.sub.2 ' is as defined above for R.sub.2 with the proviso that, if R.sub.2 is C.sub.4 -C.sub.12 alkylene interrupted by 1, 2 or 3>N--COOR.sub.3 groups, R.sub.2 ' is C.sub.4 -C.sub.12 alkylene interrupted by 1, 2 or 3--NH-- groups, at a temperature of from 0.degree. to 60.degree. C., 1 to 1.5 mol of the compound of the formula (II) being used per mol --NH-- group in the compound of the formula (III); and neutralising the hydrochloric acid formed with an inorganic base.
- 2. A process as claimed in claim 1, wherein the reaction temperature is 10.degree. to 50.degree. C.
- 3. A process according to claim 1, wherein the reaction temperature is 20.degree. to 40.degree. C.
- 4. A process according to claim 1, wherein 1 to 1.3 mol of the compound of the formula (II) are used per mol --NH-- group in the compound of the formula (III).
- 5. A process according to claim 1, wherein 1.1 to 1.2 mol of the compound of the formula (II) are used per mol --NH-- group in the compound of the formula (III).
- 6. A process according to claim 1, wherein a compound of the formula (II) is used in which R.sub.3 is C.sub.1 -C.sub.12 alkyl, C.sub.3 -C.sub.12 alkyl interrupted by 1 or 2 oxygen atoms; C.sub.3 -C.sub.12 alkenyl, cyclohexyl which is unsubstituted or mono-, di- or tri-substituted by C.sub.1 -C.sub.4 alkyl; phenyl which is unsubstituted or mono-, di- or tri-substituted by C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkoxy; or benzyl which is unsubstituted or mono-, di- or tri-substituted by C.sub.1 -C.sub.4 alkyl.
- 7. A process according to claim 1, wherein a compound of the formula (II) is used in which R3 is C.sub.1 -C.sub.8 alkyl, C.sub.3 -C.sub.6 alkyl interrupted by one oxygen atom; C.sub.3 -C.sub.6 alkenyl, cyclohexyl, phenyl or benzyl.
- 8. A process according to claim 1, wherein a compound of the formula (II) is used in which R.sub.3 is C.sub.1 -C.sub.6 alkyl, 3-oxabutyl, allyl, cyclohexyl or benzyl.
- 9. A process according to claim 1, wherein a compound of the formula (II) is used in which R.sub.3 is C.sub.1 -C.sub.4 alkyl.
- 10. A process according to claim 1, wherein a compound of the formula (III) is used in which R.sub.1 is hydrogen, C.sub.1 -C.sub.4 alkyl, benzyl which is unsubstituted or mono-, di- or tri-substituted by C.sub.1 -C.sub.4 alkyl; or C.sub.1 -C.sub.4 acyl and R.sub.2 ' is C.sub.2 -C.sub.10 alkylene, C.sub.4 -C.sub.10 alkylene interrupted by 1, 2 or 3 oxygen atoms or by 1, 2 or 3--NH-- or >N--CH.sub.3 groups; cyclohexylene, cyclohexylenedimethylene, methylenedicyclohexylene, phenylenedimethylene or methylenediphenylene.
- 11. A process according to claim 1, wherein a compound of the formula (III) is used in which R.sub.1 is hydrogen, methyl, benzyl or acetyl and R.sub.2 ' is C.sub.2 -C.sub.8 alkylene, C.sub.4 -C.sub.10 alkylene interrupted by 1, 2 or 3 oxygen atoms or by 1 or 2--NH-- or >N--CH.sub.3 groups; cyclohexylenedimethylene, methylenedicyclohexylene or phenylenedimethylene.
- 12. A process according to claim 1, wherein a compound of the formula (III) is used in which R.sub.1 is hydrogen, methyl or acetyl and R.sub.2 ' is C.sub.2 -C.sub.6 alkylene, C.sub.6 -C.sub.10 alkylene interrupted by 2 or 3 oxygen atoms; C.sub.4 -C.sub.10 alkylene interrupted by 1 or 2--NH-- groups; cyclohexylenedimethylene or methylenedicyclohexylene.
- 13. A process according to claim 1, wherein a compound of the formula (III) is used in which R.sub.1 is hydrogen and R.sub.2 ' is one of the groups --(CH.sub.2).sub.2-6 --, ##STR9##
- 14. A process according to claim 1, wherein the inorganic base used is sodium hydroxide.
Priority Claims (1)
Number |
Date |
Country |
Kind |
MI91A3330 |
Dec 1991 |
ITX |
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Parent Case Info
This application is a continuation of application Ser. No. 07/986,326, filed Dec. 7, 1992, now abandoned.
US Referenced Citations (4)
Foreign Referenced Citations (2)
Number |
Date |
Country |
0031304 |
Jul 1981 |
EPX |
0124486 |
Nov 1984 |
EPX |
Continuations (1)
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Number |
Date |
Country |
Parent |
986326 |
Dec 1992 |
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