Claims
- 1. A process for preparing dihydropyridine derivatives and salts and esters thereof represented by the formula: ##STR47## wherein R.sup.1, R.sup.2 and R.sup.4 are each a lower alkyl group; R.sup.3 is a nitro group or a lower alkyl group which may have from 1 to 3 halogen atoms as substituents; R.sup.5 is a phenyl group which may have from 1 to 3 substituents selected from the group consisting of a lower alkoxy group, a halogen atom, a lower alkylthio group, a hydroxyl group, a lower alkanoyloxy group, a tetrahydropyranyloxy group and a lower alkoxy-lower alkoxy group; and A is an unsaturated straight- or branched-chain hydrocarbon residue, by reacting a compound of the formula ##STR48## wherein R.sup.1 and R.sup.4 are the same as defined above, with a compound of the formula, ##STR49## wherein R.sup.3 is the same as defined above, in the presence of an aromatic amine selected from the group consisting of, o-anisidine, p-anisidine, m-anisidine, m-toluidine p-toluidine, p-chloroaniline, aniline and o-phenetidine, to obtain a phenyl derivative represented by the formula, ##STR50## and then reacting the phenyl derivative with an enamine derivative represented by the formula, ##STR51## wherein R.sup.2 and R.sup.5 and A are each of the same as defined above.
- 2. The process of claim 1, wherein the aromatic amine is selected from the group consisting of m-toluidine, p-toluidine, p-chloroaniline, aniline and o-phenetidine.
Priority Claims (1)
Number |
Date |
Country |
Kind |
59-165797 |
Aug 1984 |
JPX |
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Parent Case Info
This is a continuation of application Ser. No. 761,702 filed Aug. 2, 1985 now abandoned.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
4031104 |
Bossert et al. |
Jun 1977 |
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4044141 |
Bossert et al. |
Aug 1977 |
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Non-Patent Literature Citations (1)
Entry |
Jones, G., "The Knoevenagel Condensation", Organic Reactions, vol. 15, John Wiley & Sons, NY (1967). |
Continuations (1)
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Number |
Date |
Country |
Parent |
761702 |
Aug 1985 |
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