Process for preparing pyridylmethyl isothiocyanates

Abstract

The present invention relates to a novel process for preparing pyridylmethyl isothiocyanates of the formula (I) ##STR1## in which R.sup.1 represents halogen or C.sub.1 -C.sub.4 -alkyl, characterized in that in a first step, amines of the formula (II) ##STR2## in which R.sup.1 is as defined above, are reacted with xanthogenates of the formula (III)R.sup.2 O--CS--S.sup..crclbar. M.sup..sym. (III)in whichR.sup.2 represents C.sub.1 -C.sub.4 -alkyl, preferably methyl or ethyl andM represents an alkali metal, preferably sodium and potassium or represents ammonium,if appropriate in the presence of a diluent, and in a second step, the resulting novel dithiocarbamates of the formula (IV) ##STR3## in which R.sup.1 and M are each as defined above, are oxidized, if appropriate in the presence of a diluent, to give the isothiocyanates of the formula (I).

Description

The present invention relates to a novel process for preparing pyridylmethyl isothiocyanates and to novel intermediates.

It is known that pyridylmethyl isothiocyanates are obtained when pyridylmethylamines of the formula (A) are reacted with carbon disulfide and, for example, ethyl chloroformate in the presence of a base, such as, for example, sodium hydroxide, according to the following equation: ##STR4## Py=optionally substituted pyridyl, such as, for example, 2-chloro-5-pyridyl (cf. EP-A 0 302 389).

However, this process has the disadvantage that carbon disulfide is employed as reaction partner. Furthermore, carbon oxysulfide is obtained as byproduct.

It has now been found that pyridylmethyl isothiocyanates of the formula (I) ##STR5## in which R.sup.1 represents halogen or C.sub.1 -C.sub.4 -alkyl are obtained in good yields and high purity when in a first step, amines of the formula (II) ##STR6## in which R.sup.1 is as defined above, are reacted with xanthogenates of the formula (III)

R.sup.2 O--CS--S.sup..crclbar. M.sup..sym. (III) in which R.sup.2 represents C.sub.1 -C.sub.4 -alkyl, preferably methyl or ethyl and M represents an alkali metal, preferably sodium and potassium or represents ammonium, if appropriate in the presence of a diluent, and in a second step, the resulting dithiocarbamates of the formula (IV) ##STR7## in which R.sup.1 and M are each as defined above, are oxidized, if appropriate in the presence of a diluent, to give the isothiocyanates of the formula (I).

The formula (I) provides a general definition of the pyridylmethyl isothiocyanates preparable according to the invention. In this formula, R.sup.1 preferably represents chlorine or methyl.

Surprisingly, the pyridylmethyl isothiocyanates of the formula (I) can be obtained in good yields and in high purity by the process according to the invention, although the sulfur-containing radical MSH in the xanthogenates of the formula (III) is the better leaving group as compared to the alcohol radical R.sup.2 OH and the following course of reaction could therefore have been expected: ##STR8##

The reaction according to the invention has the advantage that carbon disulfide is not required as reaction partner. Moreover, the practice of the reaction is simple (no exothermic reaction) and the reaction proceeds without side reactions.

Using, for example, 5-aminomethyl-2-chloropyridine and potassium ethylxanthogenate as starting materials and aqueous NaOCl solution as oxidizing agent, the course of the reaction of the process according to the invention can be illustrated by the following equation: ##STR9##

The amines of the formula (II) to be used as starting materials in the first step of the process according to the invention are known (cf., for example, EP-A 0 391 205 or U.S. Pat. No. 4,499,097) and/or can be obtained in a generally known manner.

The xanthogenates of the formula (III) furthermore to be used as starting materials in the first step of the process according to the invention are generally known compounds.

The formula (IV) provides a general definition of the dithiocarbamates obtainable in the first step of the process according to the invention. In this formula, R.sup.1 preferably represents chlorine or methyl and M preferably represents sodium, potassium or ammonium.

The dithiocarbamates of the formula (IV) are novel and also form part of the subject matter of the present application.

Preferred oxidizing agents for the second step of the process according to the invention are: sodium hypochlorite or potassium hypochlorite solution and copper(II) compounds, such as copper sulfate.

Suitable diluents for the first step of the process according to the invention are customary organic solvents. These preferably include hydrocarbons, such as toluene or xylene; ethers such as methyl tert-butyl ether, methyl tert-amyl ether, 1,2-dimethoxyethane, 1,2-diethoxyethane, tetrahydrofuran or dioxane; alcohols, such as methanol, ethanol, n-propanol, i-propanol, n-, i-, s- or t-butanol; nitrites, such as acetonitrile, propionitrile or butyronitrile; and amides, such as dimethylformamide.

When carrying out the first step of the process according to the invention, the reaction temperatures can be varied within a relatively wide range. In general, the reaction is carried out at temperatures between 30.degree. C. and 150.degree. C., preferably at temperatures between 50.degree. C. and 120.degree. C.

When carrying out the first step of the process according to the invention, preference is given to employing equimolar amounts. However, it is also possible to employ a relatively large excess of the cheaper xanthogenate of the formula (III), preferably 100%.

The reaction is carried out and the novel dithiocarbamates of the formula (IV) are worked up and isolated in a generally customary manner (cf. also the Preparation Example).

Preferred diluents for the oxidation according to the second step of the process according to the invention are water and a second inert, sparingly water-miscible solvent, such as, for example, hydrocarbons, chlorinated hydrocarbons, ethers, nitrites, ketones or amides.

When carrying out the second step of the process according to the invention, the reaction temperatures can be varied within a relatively wide range. In general, the reaction is carried out at temperatures between -30.degree. C. and 50.degree. C., preferably at temperatures between -10.degree. C. and 10.degree. C.

When carrying out the second step of the process according to the invention, generally 4 to 5 mol, preferably 4 to 4.5 mol, of oxidizing agent are employed per mole of dithiocarbamate.

The reaction is carried out and the pyridylmethyl isothiocyanates of the formula (I) are worked up and isolated in a generally customary manner (cf. also the Preparation Example).

The pyridylmethyl isothiocyanates of the formula (I) to be prepared by the process according to the invention can be used as intermediates for preparing biologically active compounds, for example insecticides (cf., for example, EP-A 0 302 389).

PREPARATION EXAMPLES

Example 1 ##STR10## 51.3 g (0.2 mol) of potassium 2-chloro-5-pyridylmethyldithiocarbamate (cf. first step) are dissolved in 200 ml of water and admixed with 200 ml of methylene chloride.

At 0.degree. C., 460 ml of 13% strength aqueous NaOCl solution are added dropwise in such a manner that the temperature does not exceed 5.degree. C. The mixture is stirred at 0-5.degree. C. for 30 minutes, the organic phase is separated off, the aqueous phase is extracted three times with methylene chloride and the combined organic phases are dried with sodium sulfate.

The solvent is distilled off, giving 31.3 g (82% of theory) of 2-chloro-5-pyridylmethyl isothiocyanate which crystallizes in the fridge (melting point: 22.degree. C.) ##STR11## 2.85 g (20 mmol) of 2-chloro-5-aminomethyl-pyridine and 3.2 g (20 mmol) of potassium ethylxanthogenate in 30 ml of ethanol are stirred under reflux overnight.

The mixture is allowed to cool and filtered off: This gives 4.4 g (86% of theory) of potassium 2-chloro-5-pyridylmethyldithiocarbamate of melting point 252.degree. C. (decomp.).

Claims

1. A dithiocarbamate of the formula (IV): ##STR12## in which R.sup.1 represents halogen; and

M represents an alkali metal selected from the group consisting of sodium and potassium, or represents ammonium.

2. The dithiocarbamate according to claim 1, wherein M represents an alkai metal selected from the group consisting of sodium and potassium.

3. The dithiocarbamate according to claim 1, wherein M represents ammonium.