Claims
- 1. A method of making a compound of Formula I,
- 2. The method of claim 1, wherein the tertiary hydroxy group is displaced using radical deoxygenation.
- 3. The method of claim 1, further comprising:
reacting a compound of Formula III, 10or a corresponding stereoisomer having opposite stereochemistry of Formula III, with zinc to form an organozinc reagent; and reacting the organozinc reagent with hexafluoroacetone to yield the compound of Formula IV or the corresponding stereoisomer, wherein R1 and R2 in Formula III are as defined in Formula I.
- 4. The method of claim 3, further comprising:
reacting a compound of Formula II, 11or a corresponding stereoisomer having opposite stereochemistry of Formula II, with an iodinating agent to yield the compound of Formula II or the corresponding stereoisomer, wherein R1 and R2 in Formula II are as defined in Formula I.
- 5. The method of claim 1, further comprising:
de-protecting the compound of Formula I or the corresponding stereoisomer having opposite stereochemistry of Formula I by replacing R1 or R2 or both R1 and R2 with a hydrogen atom.
- 6. The method of claim 1, wherein R1 is benzyl, substituted benzyl, Cbz, Boc, Fmoc, or trityl, and R2 is alkyl or haloalkyl.
- 7. The method of claim 1, wherein R1 is Cbz.
- 8. The method of claim 1, wherein R2 is tert-butyl.
- 9. A method of making a compound of Formula IV,
- 10. The method of claim 9, wherein R1 is benzyl, substituted benzyl, Cbz, Boc, Fmoc, or trityl, and R2 is alkyl or haloalkyl.
- 11. The method of claim 9, wherein R1 is Cbz.
- 12. The method of claim 9, wherein R2 is tert-butyl.
- 13. A method of making a compound represented by Formula I,
- 14. The method of claim 13, further comprising:
de-protecting the compound of Formula I or the corresponding stereoisomer having opposite stereochemistry of Formula I by replacing R1 or R2 or both R1 and R2 with a hydrogen atom.
- 15. The method of claim 13, wherein R1 is benzyl, substituted benzyl, Cbz, Boc, Fmoc, or trityl, and R2 is alkyl or haloalkyl.
- 16. The method of claim 13, wherein R1 is Cbz.
- 17. The method of claim 13, wherein R2 is tert-butyl.
- 18. The method of claim 13, wherein the iodinating agent is methyltriphenoxyphosphonium iodide.
- 19. A compound of Formula IV,
- 20. The compound of claim 19, wherein R1 is benzyl, substituted benzyl, Cbz, Boc, Fmoc, or trityl, and R2 is alkyl or haloalkyl.
Parent Case Info
[0001] This United States utility application claims the benefit of U.S. Provisional Application No. 60/411,489 filed Sep. 17, 2002.
Provisional Applications (1)
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Number |
Date |
Country |
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60411489 |
Sep 2002 |
US |