Claims
- 1. A process for preparing a stable emulsion in a physiologically acceptable aqueous medium, of an oxygen-transferable saturated aliphatic perfluorocarbon compound having 9 to 11 carbon atoms and a particle size of about 0.05 to about 0.3 .mu., the perfluorocarbon compound having a boiling point ranging from about 140.degree. to about 160.degree. C. and having at least one alicyclic ring, heterocyclic ring, nitrogen atom or oxygen atom, consisting essentially of homogeneously mixing a phospholipid of 2 to 6% (W/V) as emulsifier, at least one fatty acid compound of 0.001 to 0.1% (W/V) as emulsifying adjuvant selected from the group consisting of fatty acids having 8 to 22 carbon atoms, physiologically acceptable salts and monoglycerides thereof, and said perfluorocarbon compound of 10 to 40% (W/V) in said physiologically acceptable aqueous medium to obtain a crude emulsion, and further emulsifying the crude emulsion by injecting it at a temperature of 45.degree. to 55.degree. C through a slit under a pressure of about 100 kg/cm.sup.2 to 500 kg/cm.sup.2, thereby subjecting it to shearing force and mixing action based on a strong velocity gradient until the particle size of the perfluorocarbon compound in the resulting emulsion reaches 0.05 to 0.3 .mu..
- 2. The process according to claim 1, wherein the perfluorocarbon compound is a perfluorocycloalkane or perfluoro (alkylcycloalkane).
- 3. The process according to claim 2, wherein the perfluorocycloalkane is perfluorodecalin or perfluoro (methyldecalin).
- 4. The process according to claim 2, wherein the perfluorocycloalkane is a perfluoro (butylcyclohexane), perfluoro (methylpropylcyclohexane), perfluoro (trimethylcyclohexane), perfluoro (ethylpropylcyclohexane) or perfluoro (pentylcyclohexane).
- 5. The process according to claim 1, wherein the perfluorocarbon compound is a perfluoro-saturated heterocyclic compound.
- 6. The process according to claim 5, wherein the perfluoro-saturated heterocyclic compound is perfluoro (butyltetrahydropyran), perfluoro (pentyltetrahydrofuran), perfluoro (hexyltetrahydrofuran), perfluoro (heptyltetrahydrofuran), perfluoro (N-hexylpiperidine), perfluoro (N-butylpiperidine), perfluoro (N-pentylmorpholine), perfluoro (N-hexylmorpholine) or perfluoro (N-heptylmorpholine).
- 7. The process according to claim 1, wherein the perfluorocarbon compound is a perfluoro-tert-amine or perfluoro (dioxa-alkane).
- 8. The process according to claim 7, wherein the perfluoro compound is a perfluoro (diethylhexylamine), perfluoro (dipropylbutylamine) or perfluoro (diethylcyclohexylamine).
- 9. The process according to claim 7, wherein the perfluoro compound is perfluoro (tetramethylene glycol diisobutyl ether), perfluoro (trimethylene glycol diisobutyl ether) or perfluoro (isopropylidene glycol di-n-propyl ether).
- 10. The process according to claim 1, wherein the physiologically acceptable aqueous medium is an isotonic solution.
- 11. The process according to claim 10, wherein the isotonic solution is 2.5% by weight aqueous glycerine solution.
- 12. The process according to claim 1, wherein the fatty acid compound is caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, palmitoleic acid, oleic acid, linoleic acid or arachidonic acid.
- 13. The process according to claim 1 wherein the fatty acid compound is an alkali metal salt of a fatty acid selected from the group consisting of caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, palmitoleic acid, oleic acid, linoleic acid and arachidonic acid.
- 14. The process according to claim 13, wherein the alkali metal salt of the fatty acid is potassium palmitate.
- 15. The process according to claim 13, wherein the alkali metal salt of the fatty acid is sodium oleate.
- 16. The process according to claim 1, wherein the fatty acid compound is a monoglyceride of a fatty acid selected from the group consisting of caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, palmitoleic acid, oleic acid, linoleic acid and arachidonic acid.
- 17. The process according to claim 1, wherein the phospholipid is egg yolk phospholipid or soybean phospholipid.
Priority Claims (1)
Number |
Date |
Country |
Kind |
48-112047 |
Oct 1973 |
JA |
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Parent Case Info
This is a division of application Ser. No. 439,638, filed Feb. 4, 1974, now U.S. Pat. No. 3,962,439.
US Referenced Citations (7)
Foreign Referenced Citations (1)
Number |
Date |
Country |
2,105,287 |
Apr 1972 |
FR |
Divisions (1)
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Number |
Date |
Country |
Parent |
439638 |
Feb 1974 |
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