TREA

Process for preparing substituted chroman derivatives

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  • Patent Grant
  • 6136986
  • Patent Number
    6,136,986
  • Date Filed
    Monday, December 13, 1999
    24 years ago
  • Date Issued
    Tuesday, October 24, 2000
    24 years ago
Information
Abstract
The invention relates to a process for preparing substituted chroman derivatives of the general formula VII, ##STR1## where X is the group --CN, --COOR.sup.3, --CHO, --CH.sub.2 OR.sup.7 or --CH(OR.sup.8).sub.2,R.sup.2 is a C.sub.1 -C.sub.23 -alkyl, C.sub.2 -C.sub.23 -alkenyl, C.sub.6 -C.sub.18 -aryl or C.sub.7 -C.sub.18 -aralkyl radical,R.sup.3 is hydrogen or an optionally substituted C.sub.1 -C.sub.4 -alkyl radical,R.sup.4, R.sup.5, R.sup.6 are, independently of one another, hydrogen or a C.sub.1 -C.sub.4 -alkyl radical,R.sup.7 is hydrogen or a C.sub.1 -C.sub.4 -alkyl radical,R.sup.8 is a C.sub.1 -C.sub.4 -alkyl radical, or the two radicals are a C.sub.2 -C.sub.6 -alkylene radical which links the two oxygen atoms to form a cyclic acetal and is optionally branched or may carry one or two carboxyl groups, cyclohexyl or phenyl radicals,and to the novel intermediates of the process.
Description

The invention relates to a process for preparing substituted chroman derivatives of the general formula VII, ##STR2## where X is the group --CN, --COOR.sup.3, --CHO, --CH.sub.2 OR.sup.7 or --CH(OR.sup.8).sub.2,
R.sup.2 is a C.sub.1 -C.sub.23 -alkyl, C.sub.2 -C.sub.23 -alkenyl, C.sub.6 -C.sub.18 -aryl or C.sub.7 -C.sub.18 -aralkyl radical,
R.sup.3 is hydrogen, a C.sub.1 -C.sub.4 -alkyl radical, a C.sub.1 -C.sub.4 -haloalkyl radical, a C.sub.1 -C.sub.4 -hydroxyalkyl radical or a C.sub.1 -C.sub.4 -aminoalkyl radical,
R.sup.4, R.sup.5, R.sup.6 are, independently of one another, hydrogen or a C.sub.1 -C.sub.4 -alkyl radical,
R.sup.7 is hydrogen or a C.sub.1 -C.sub.4 -alkyl radical,
R.sup.8 is a C.sub.1 -C.sub.4 -alkyl radical, or the two radicals are a C.sub.2 -C.sub.6 -alkylene radical which links the two oxygen atoms to form a cyclic acetal and is optionally branched or may carry one or two carboxyl groups, cyclohexyl or phenyl radicals,
and to the novel intermediates for the process.
The substituted chroman derivatives of the general formula VII are known intermediates in demand for pharmaceutical agents and vitamins (e.g. tocopherol). Starting from 6-acetyloxychroman-2-aldehyde it has been possible to prepare, inter alia, .alpha.-tocopherol by a Wittig reaction with a phosphonium salt (T. Netscher, Chimia 1996, 50, 563-567; H. Mayer, P. Schudel, R. Ruegg, O. Isler, Helv. Chim. Acta 1963, 46, 650). In addition, these compounds, e.g. the 6-hydroxychroman-2-carboxylic acids, themselves have an antioxidant effect in animal fat, vegetable oils and emulsions (J. W. Scott et al., J. of the American Oil Chemists Society, 1974, 51, 200-203).
The preparation of substituted chroman derivatives by condensation of the corresponding hydroquinones with allyl alcohols has been disclosed (U.S. Pat. No 2,411,969, WO 9821197 A2).
In addition, DE 2364141 A1 describes a similar approach by reaction of a hydroquinone with unsaturated ketones or acetals in the presence of an acid.
It is common to all the processes described to date that the aromatic system is employed as synthon and the pyran moiety is subsequently built on by electrophilic aromatic substitution.
These reactions have the disadvantage that chromans unsubstituted in the aromatic system are difficult to prepare because these electron-rich aromatic systems are prone to multiple alkylation.
Moreover, with different alkyl groups on the aromatic system, regioselectivity problems arise in the abovementioned syntheses, i.e. it is not possible to prepare all desired substitution patterns on the aromatic moiety in the chroman structure equally satisfactorily.
It is an object of the present invention to develop a process for preparing the chroman derivatives which is more flexible in terms of the substituents, is economical and proceeds via easily handled intermediates and reagents.
We have found that this object is achieved in that the chroman derivatives of the general formula VII mentioned at the outset can be prepared by a multistage process, which comprises, in a first step, reacting substituted acroleins of the general formula I, ##STR3## where R.sup.1 is a C.sub.1 -C.sub.4 -alkyl, C.sub.6 -C.sub.18 -aryl, C.sub.7 -C.sub.18 -aralkyl, C.sub.1 -C.sub.4 -acyl, a halogenated C.sub.1 -C.sub.4 -acyl radical or another acid-labile protective group for the hydroxyl group,
with acrylonitriles, acrylates, acroleins, acrolein acetals, allyl alcohols or allyl ethers of the general formula II ##STR4## to give the corresponding 3,4-dihydro-2H-pyrans of the general formula III ##STR5## and, in a second step, reacting the latter with an acid to give the corresponding 5-oxotetrahydropyrans of the general formula IV ##STR6## and, in a third step, reacting the latter with substituted vinyl ketones of the general formula V ##STR7## to give the corresponding chromen-6-one derivatives of the general formula VI ##STR8## and, in a 4th step, dehydrogenating the latter to give the substituted chroman derivatives of the general formula VII.
The starting materials for the process are substituted acroleins of the general formula I and acrylonitriles, acrylates, acroleins, acrolein acetals, allyl alcohols or allyl ethers of the general formula II.
The substituted acroleins of the general formula I in the first step of the process according to the invention are the diene component in a hetero-Diels-Alder reaction.
The R.sup.1 radical in the substituted acroleins can be a C.sub.1 -C.sub.4 -alkyl, C.sub.6 -C.sub.18 -aryl, C.sub.7 -C.sub.18 -aralkyl, an optionally halogenated C.sub.1 -C.sub.4 -acyl radical or another acid-labile protective group for the hydroxyl group. A C.sub.1 -C.sub.4 -alkyl radical means a methyl, ethyl, n-propyl, i-propyl, n-butyl, i-butyl or t-butyl radical, with methyl being preferred. Examples of C.sub.6 -C.sub.18 -aryl radicals are phenyl, naphthyl or phenyl which is optionally substituted one to three times by C.sub.1 -C.sub.4 -alkyl radicals. C.sub.7 -C.sub.18 -Aralkyl radicals mean radicals such as benzyl or phenylethyl.
Examples of C.sub.1 -C.sub.4 -acyl radicals or halogenated C.sub.1 -C.sub.4 -acyl radicals, i.e. those substituted by one to three identical or different halogen radicals such as Cl, Br, I or F, are acetyl, monochloro-, dichloro- or trichloroacetyl, trifluoroacetyl, propionyl or butyryl.
R.sup.1 can also be another acid-labile protective group for the hydroxyl group of the enol. It is possible in principle to use any acid-labile protective group. Preferred acid-labile protective groups are the acid-labile protective groups for hydroxyl groups disclosed in the literature (T. W. Greene, Protective Groups in Organic Synthesis, John Wiley & Sons New York, 1981, pages 14-71; P. J. Kocienski, Protecting Groups, Georg Thieme Verlag Stuttgart, 1994, pages 21-94). Particularly preferred acid-labile protective groups are
esters such as
phenylacetates, triphenylmethoxyacetate, phenoxyacetates, halophenoxyacetates, haloalkylphenoxyacetates, formate, benzoylformate, 3-phenylpropionate, isobutyrate, pivaloate, adamantoate, crotonates or benzoates;
or
aliphatic and aromatic ethers such as methyl, benzyl, o-nitrobenzyl, p-methoxybenzyl, 3,4-dimethoxybenzyl ethers, trityls, p-methoxyphenyl(diphenyl)methyl, 4,4', 4"-tris(benzoyloxy)trityl, di(p-methoxyphenyl)phenylmethyl, tert-butyls, 9-phenyl-9-xanthenyl, allyls, 2-(trimethylsilyl)ethyl.
Preferred substituted acroleins of the general formula I are .alpha.-methoxyacrolein, .alpha.-benzyloxyacrolein or acetoxyacrolein.
The substituted acrylonitriles (X=--CN), acroleins (X=--CHO), acrylates (X=--COOR.sup.3), acrolein acetals (X=--CH(OR.sup.8).sub.2), allyl ethers (X=--CH.sub.2 OR.sup.7) or allyl alcohols (X=--CH.sub.2 OR.sup.7 ; R.sup.7 =hydrogen) of the general formula II in the first step of the process according to the invention are the ene component in a hetero-Diels-Alder reaction.
The R.sup.2 radical can be a C.sub.1 -C.sub.23 -alkyl radical such as methyl, ethyl, n-propyl, i-propyl, n-Butyl, i-butyl, t-butyl, pentyl, hexyl, heptyl, octyl, nonyl or 4,8,12-trimethyltridecyl, in particular methyl, a C.sub.2 -C.sub.23 -alkenyl radical such as ethenyl(vinyl), propenyl (allyl), 4-methyl-3-pentenyl, 4,8-dimethyl-3,7-nonadienyl or 4,8,12-trimethyl-3,7,11-tridecatrienyl, a C.sub.6 -C.sub.18 -aryl radical as mentioned above for R.sup.1, in particular phenyl, or a C.sub.7 -C.sub.18 -aralkyl radical as mentioned above for R.sup.1, in particular benzyl.
Preferred R.sup.2 -substituted acrylonitriles (X=--CN) of the formula II are 2-methylacrylonitrile, 2-(4,8,12-trimethyltridecyl)-acrylonitrile, 2-(4-methyl-3-pentenyl)acrylonitrile, 2-(4,8-dimethyl-3,7-nonadienyl)acrylonitrile or 2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)acrylonitrile.
Preferred R.sup.2 -substituted acroleins (X=--CHO) of the formula II are 2-methylacrolein (methacrolein), 2-(4,8,12-trimethyl-tridecyl)acrolein, 2-(4-methyl-3-pentenyl)acrolein, 2-(4,8-dimethyl-3,7-nonadienyl)acrolein or 2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)acrolein.
R.sup.2 -substituted acrylates (X=--COOR.sup.3) mean substituted acrylic acids (R.sup.3 =hydrogen) or acrylic esters (R.sup.3 =a C.sub.1 -C.sub.4 -alkyl radical, a C.sub.1 -C.sub.4 -haloalkyl radical, a C.sub.1 -C.sub.4 -hydroxyalkyl radical or a C.sub.1 -C.sub.4 -aminoalkyl radical).
C.sub.1 -C.sub.4 -Alkyl radicals for R.sup.3 mean the C.sub.1 -C.sub.4 -alkyl radicals mentioned above for R.sup.1, in particular methyl or ethyl.
C.sub.1 -C.sub.4 -Haloalkyl radicals mean C.sub.1 -C.sub.4 -alkyl radicals substituted by one to three identical or different halogen radicals such as F, Cl, Br or I. Examples of C.sub.1 -C.sub.4 -haloalkyl radicals are 2-chloroethyl, 1,2-dichloroethyl or 2,2,2-trichloroethyl and the corresponding bromoethyl radicals.
C.sub.1 -C.sub.4 -Hydroxyalkyl radicals mean C.sub.1 -C.sub.4 -alkyl radicals substituted by one to three hydroxyl groups. Examples of C.sub.1 -C.sub.4 -hydroxyalkyl radicals are 2-hydroxyethyl or 1,2-dihydroxyethyl.
C.sub.1 -C.sub.4 -Aminoalkyl radicals mean C.sub.1 -C.sub.4 -alkyl radicals substituted by one to three amino groups. Amino groups mean NH.sub.2 groups, mono(C.sub.1 -C.sub.4 -)alkylamino groups or di(C.sub.1 -C.sub.4 -)alkylamino groups. Examples of C.sub.1 -C.sub.4 -aminoalkyl radicals are aminoethyl, 2-methylaminoethyl, 2-dimethylaminoethyl or ethylmethylaminoethyl.
Preferred substituted acrylates of the general formula II are 2-methylacrylic acid (methacrylic acid), methyl methacrylate, ethyl methacrylate, 2-hydroxyethyl methacrylate, 2-chloroethyl methacrylate, 2-dimethylaminoethyl methacrylate, 2-(4,8,12-trimethyltridecyl)acrylic acid, 2-(4-methyl-3-pentenyl)-acrylic acid, 2-(4,8-dimethyl-3,7-nonadienyl)acrylic acid, 2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)acrylic acid, methyl 2-(4,8,12-trimethyltridecyl)acrylate, methyl 2-(4-methyl-3-pentenyl)acrylate, methyl 2-(4,8-dimethyl-3,7-nonadienyl)acrylate, methyl 2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)acrylate, ethyl 2-(4,8,12-trimethyltridecyl)acrylate, ethyl 2-(4-methyl-3-pentenyl)acrylate, ethyl 2-(4,8-dimethyl-3,7-nonadienyl)acrylate, ethyl 2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)acrylate, 2-hydroxyethyl 2-(4,8,12-trimethyltridecyl)acrylate, 2-hydroxyethyl 2-(4-methyl-3-pentenyl)acrylate, 2-hydroxyethyl 2-(4,8-dimethyl-3,7-nonadienyl)acrylate, 2-hydroxyethyl 2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)acrylate, 2-chloroethyl 2-(4,8,12-trimethyltridecyl)acrylate, 2-chloroethyl) 2-(4-methyl-3-pentenyl)acrylate, 2-chloroethyl 2-(4,8-dimethyl-3,7-nonadienyl)acrylate or 2-chloroethyl 2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)acrylate, 2-dimethylamino ethyl 2-(4,8,12-trimethyltridecyl)acrylate, 2-dimethylaminoethyl 2-(4-methyl-3-pentenyl)acrylate, 2-dimethylaminoethyl 2-(4,8-dimethyl-3,7-nonadienyl)acrylate or 2-dimethylaminoethyl 2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)- acrylate.
In the case of the R.sup.2 -substituted allyl ethers (X=--CH.sub.2 OR.sup.7) or allyl alcohols (X=--CH.sub.2 OR.sup.7 ; R.sup.7 =hydrogen), R.sup.7 can be hydrogen or a C.sub.1 -C.sub.4 -alkyl radical as described above for R.sup.1, in particular methyl or ethyl.
Preferred substituted allyl ethers of the general formula II are 2-methyl-3-methoxypropene, 2-methyl-3-ethoxypropene, 2-(4,8,12-trimethyltridecyl)-3-methoxypropene, 2-(4-methyl-3-pentenyl)-3-methoxypropene, 2-(4,8-dimethyl-3,7-nonadienyl)-3-methoxypropene, 2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-3-methoxypropene, 2-(4,8,12-trimethyltridecyl)-3-ethoxypropene, 2-(4-methyl-3-pentenyl)-3-ethoxypropene, 2-(4,8-dimethyl-3,7-nonadienyl)-3-ethoxypropene or 2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-3-ethoxypropene.
Preferred substituted allyl alcohols of the general formula II are 2-methyl-2-propen-1-ol (2-methylallyl alcohol, methallyl alcohol), 2-(4,8,12-trimethyltridecyl)-2-propen-1-ol, 2-(4-methyl-3-pentenyl)-2-propen-1-ol, 2-(4,8-dimethyl-3,7-nonadienyl)-2-propen-1-ol or 2-(4,8,12-trimethyl-3,7,11-trideca-trienyl)-2-propen-1-ol.
In the case of the R.sup.2 -substituted acrolein acetals (X=--CH (OR.sup.8).sub.2), R.sup.8 is a C.sub.1 -C.sub.4 -alkyl radical as described above for R.sup.1, in particular methyl, or the two R.sup.8 radicals are a C.sub.2 -C.sub.6 -alkylene radical which links the two oxygen atoms to form a cyclic acetal and is optionally branched or carries up to two carboxyl groups, cyclohexyl or phenyl radicals. Preferred C.sub.2 -C.sub.6 -alkylene radicals are ethylene, propylene, butylene or neopentylene. Preferred C.sub.2 -C.sub.6 -alkylene radicals carrying up to two carboxyl groups, cyclohexyl or phenyl radicals are ethylene radicals substituted in position 1 and/or 2 by said radicals. Symmetrically substituted C.sub.2 linkers are preferably those listed below, where the linkage points are indicated by a line showing the stereochemistry: ##STR9##
Preferred substituted acrolein acetals of the general formula II are accordingly 2-methyl-3,3-dimethoxypropene, 2-methyl-3,3-diethoxypropene, 2-methyl-3,3-dipropoxypropene, 2-methyl-3,3-dibutoxypropene, 2-(4,8,12-trimethyltridecyl)-3,3-dimethoxypropene, 2-(4,8,12-trimethyltridecyl)-3,3-diethoxypropene, 2-(4,8,12-trimethyltridecyl)-3,3-dipropoxypropene, 2-(4,8,12-trimethyltridecyl)-3,3-dibutoxypropene, 2-(4,8,12-trimethyltridecyl)-3,3-dimethoxypropene, 2-(4,8,12-trimethyltridecyl)-3,3-diethoxypropene, 2-(4,8,12-trimethyltridecyl)-3,3-dipropoxypropene, 2-(4,8,12-trimethyltridecyl)-3,3-dibutoxypropene, 2-(4-methyl-3-pentenyl)-3,3-dimethoxypropene, 2-(4-methyl-3-pentenyl)-3,3-diethoxypropene, 2-(4-methyl-3-pentenyl)-3,3-dipropoxypropene, 2-(4-methyl-3-pentenyl)-3,3-dibutoxypropene, 2-(4,8-dimethyl-3,7-nonadienyl)-3,3-dimethoxypropene, 2-(4,8-dimethyl-3,7-nonadienyl)-3,3-diethoxypropene, 2-(4,8-dimethyl-3,7-nonadienyl)-3,3-dipropoxypropene, 2-(4,8-dimethyl-3,7-nonadienyl)-3,3-dibutoxypropene, 2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-3,3-dimethoxypropene, 2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-3,3-diethoxypropene, 2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-3,3-dipropoxypropene, 2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-3,3-dibutoxypropene, 2-(1-methylvinyl)-4,5-dimethyl[1,3]dioxane, 2-(1-(4,8,12-trimethyltridecyl)vinyl)-4,5-dimethyl[1,3]dioxane, 2-(1-(4-methyl-3-pentenyl)vinyl)-4,5-dimethyl[1,3]dioxane, 2-(1-(4,8-dimethyl-3,7-nonadienyl)vinyl)-4,5-dimethyl[1,3]-dioxane, 2-(1-(4,8,12-trimethyl-3,7,11-tridecatrienyl)vinyl)-4,5-dimethyl[1,3]dioxane, 2-(1-methylvinyl)-4,5-dicyclohexyl-[1,3]-dioxolane, 2-(1-(4,8,12-trimethyltridecyl)vinyl)-4,5-dicyclo-hexyl[1,3]dioxolane, 2-(1-(4-methyl-3-pentenyl)vinyl)-4,5-dicyclohexyl-[1,3]dioxolane, 2-(1-(4,8-dimethyl-3,7-nonadienyl)vinyl)-4,5-dicyclohexyl-[1,3]-dioxolane, 2-(1-(4,8,12-trimethyl-3,7,11-tridecatrienyl)vinyl)-4,5-dicyclo-hexyl-[1,3]dioxolane, 2-(1-methylvinyl)-[4R,5R]-4,5-dicyclohexyl-[1,3]dioxolane, 2-(1-(4,8,12-trimethyltridecyl)vinyl)-[4R,5R]-4,5-dicyclohexyl-[1,3]dioxolane, 2-(1-(4-methyl-3-pentenyl)-vinyl)-[4R,5R]-4,5-dicyclohexyl-[1,3]dioxolane, 2-(1-(4,8-dimethyl-3,7-nonadienyl)vinyl)-[4R,5R]-4,5-dicyclo-hexyl-[1,3]dioxolane, 2-(1-(4,8,12-trimethyl-3,7,11-tridecatrienyl)vinyl)-[4R,5R]-4,5-dicyclohexyl-[1,3]dioxolane, 2-(1-methylvinyl)-[4S,5S]-4,5-dicyclohexyl-[1,3]dioxolane, 2-(1-(4,8,12-trimethyltridecyl)vinyl)-[4S,5S]-4,5-dicyclohexyl-[1,3]dioxolane, 2-(1-(4-methyl-3-pentenyl)vinyl)-[4S,5S]-4,5-dicyclohexyl-[1,3]dioxolane, 2-(1-(4,8-dimethyl-3,7-nonadienyl)vinyl)-4,5-dicyclohexyl-[1,3]dioxolane, 2-(1-(4,8,12-trimethyl-3,7,11-tridecatrienyl)vinyl)-[4S,5S]-4,5-dicyclohexyl-[1,3]dioxolane, 2-(1-methylvinyl)-4,5-diphenyl-[1,3]dioxolane, 2-(1-(4,8,12-trimethyltridecyl)vinyl)-4,5-diphenyl-[1,3]dioxolane, 2-(1-(4-methyl-3-pentenyl)vinyl)-4,5-diphenyl-[1,3]dioxolane, 2-(1-(4,8-dimethyl-3,7-nonadienyl)-vinyl)-4,5-diphenyl-[1,3]dioxolane, 2-(1-(4,8,12-trimethyl-3,7,11-tridecatrienyl)vinyl)-4,5-diphenyl-[1,3]-dioxolane, 2-(1-methylvinyl)-[4R,5R]-4,5-diphenyl-[1,3]dioxolane, 2-(1-(4,8,12-trimethyltridecyl)vinyl)-[4R,5R]-4,5-diphenyl-[1,3]-dioxolane, 2-(1-(4-methyl-3-pentenyl)vinyl)-[4R,5R]-4,5-diphenyl-[1,3]dioxolane, 2-(1-(4,8-dimethyl-3,7-nonadienyl)-vinyl)-[4R,5R]-4,5-diphenyl-[1,3]dioxolane, 2-(1-(4,8,12-trimethyl-3,7,11-tridecatrienyl)vinyl)-[4R,5R]-4,5-diphenyl-[1,3]dioxolane, 2-(1-methylvinyl)-[4S,5S]-4,5-diphenyl-[1,3]dioxolane, 2-(1-(4,8,12-trimethyltridecyl)vinyl)-[4S,5S]-4,5-diphenyl-[1,3]dioxolane, 2-(1-(4-methyl-3-pentenyl)vinyl)-[4S,5S]-4,5-diphenyl-[1,3]dioxolane, 2-(1-(4,8-dimethyl-3,7-nonadienyl)vinyl)-4,5-diphenyl-[1,3]dioxolane, 2-(1-(4,8,12-trimethyl-3,7,11-tridecatrienyl)vinyl)-[4S,5S]-4,5-diphenyl-[1,3]dioxolane, 2-(1-methylvinyl)-[1,3]dioxolane-4,5-dicarboxylic acid, 2-(1-(4,8,12-trimethyltridecyl)vinyl)-[1,3]dioxolane-4,5-dicarboxylic acid, 2-(1-(4-methyl-3-pentenyl)-vinyl)- [1,3]dioxolane-4,5-dicarboxylic acid, 2-(1-(4,8-dimethyl-3,7-nonadienyl)vinyl)-[1,3]dioxolane-4,5-dicarboxylic acid, 2-(1-(4,8,12-trimethyl-3,7,11-tridecatrienyl)vinyl)-[1,3]-dioxolane-4,5-dicarboxylic acid, 2-(1-methylvinyl)- [1,3]-dioxolane-[4R,5R]-4,5-dicarboxylic acid, 2-(1-(4,8,12-trimethyltridecyl)vinyl)-[1,3]dioxolane-[4R,5R]-4,5-dicarboxylic acid, 2-(1-(4-methyl-3-pentenyl)vinyl)-[1,3]-dioxolane-[4R, 5R]-4,5-dicarboxylic acid, 2-(1-(4,8-dimethyl-3,7-nonadienyl)vinyl)-[1,3]dioxolane-[4R,5R]-4,5-dicarboxylic acid, 2-(1-(4,8,12-trimethyl-3,7,11-tridecatrienyl)vinyl)-[1,3]-dioxolane-[4R,5R]-4,5-dicarboxylic acid, 2-(1-methylvinyl)-[1,3]dioxolane-[4S,5S]-4,5-dicarboxylic acid, 2-(1-(4,8,12-trimethyltridecyl)vinyl)-[1,3]dioxolane-[4S,5S]-4,5-dicarboxylic acid, 2-(1-(4-methyl-3-pentenyl)vinyl)-[1,3]-dioxolane-[4S,5S]-4,5-dicarboxylic acid, 2-(1-(4,8-dimethyl-3,7-nonadienyl)vinyl)-[1,3]dioxolane-[4S,5S]-4,5-dicarboxylic acid or 2-(1-(4,8,12-trimethyl-3,7,11-tridecatrienyl)vinyl)-[1,3]dioxolane-[4S,5S]-4,5-dicarboxylic acid.
In the first step of the process according to the invention, the diene component of the general formula I is reacted with the ene component of the general formula II in a 4+2 cycloaddition (hetero-Diels-Alder reaction).
Hetero-Diels-Alder reactions of electron-poor ene components such as acrylates, acroleins, allyl alcohols or crotonates with acrolein or acroleins alkylated at position 1 or 2 are known.
Thus, it is known that equimolar amounts of methyl vinyl ketone and methyl methacrylate can be converted under (hetero-)Diels-Alder conditions (200.degree. C., 2h) into the mixed Diels-Alder product (2-(carboxymethyl)-2,6-dimethyl-3,4-dihydro-2H-pyran) and the methyl vinyl ketone dimer in the ratio 1:1 (B. P. Mundy, R. D. Otzenberger, A. R. DeBernadis, J. Org. Chem., 36, 1971, p. 2390). More recent investigations confirm this result (J. G. Jun, D. W. Lee, Tetrahedron Lett. 1997, 38, p. 8207, last line, to p. 8208, 2nd paragraph). In addition, B. P. Mundy et al. describe in the above publication that the reaction of methyl vinyl ketone with acrolein methylated in position 2 (methacrolein) does not lead to the required hetero-Diels-Alder product, whereas methyl vinyl ketone and acrolein can be converted into the required hetero-Diels-Alder product. Reaction of 1-methylacrolein with 2-methyl-allyl alcohol leads via the hetero-Diels-Alder product to the bicyclic natural substance frontalin (B. P. Mundy, K. B. Lipkowitz, G. W. Dirks, Heterocycles 1977, 6, p. 64, equation 11). Gore et al. were able to show that 2-methyl-1-penten-3-one and methyl crotonate cannot be reacted to give the required regioisomeric hetero-Diels-Alder product, whereas reaction of 2-methyl-1-penten-3-one with methyl methacrylate leads to the required regioisomeric hetero-Diels-Alder product (W. E. Gore, G. T. Pearce, R. M. Silverstein, J. Org. Chem 1976, 41, pp. 603-604). In addition, Smith et al. describe further hetero-Diels-Alder reactions of alkylated acroleins with alkyl-substituted alkyl vinyl ethers and acrylates (U.S. Pat. No. 2,514,168; C. W. Smith, D. G. Norton, S. A. Ballard, J. Am. Chem. Soc. 1951, pp. 5267-5272).
It is known that introduction of radicals with electron donor properties in position 2 of 1-methylacrolein greatly reduces the reactivity of 1-methylacrolein as diene component in a Diels-Alder reaction (D. L. Boger, S. M. Weinreb, Hetero Diels-Alder--Methodology in Organic Synthesis, Academic Press, Inc, 1987, pp. 185 f.). Thus, only one example, the Diels-Alder dimerization of 3-trimethylsilyloxy-3-buten-2-one (position 3 of 3-buten-2-one corresponds to position 2 of 1-methylacrolein), is known in which the dimerization of methylacrolein with a silyloxy radical in position 2 succeeded in a Diels-Alder reaction (S. Murai; I. Ryu, Y. Kadono, H. Katayama, K. Kondo, N. Sonoda, Chem. Lett. 1977, 1219 f.). Mixed Diels-Alder reactions of acroleins having an electron donor as radical in position 2 with dienophiles are known in only a few cases (D. L. Boger, S. M. Weinreb, loc. cit.). The acroleins moreover have in position 2 a phenylthio radical and react exclusively with electron-rich ene components such as ethyl vinyl ether (K. Takaki, M. Yamada, K. Negoro, J. Org. Chem. 1982, 47, 5246-5250). Funk et al. describe a mixed, Yb-catalyzed, hetero-Diels-Alder reaction of an acrolein with a phenylacyloxy radical in position 2 with the electron-rich ene component ethyl vinyl ether (J. Org. Chem. 1996, 61, 2599, Reaction (e)).
The reaction according to the invention of the oxy-functionalized diene component of the formula I with the electron-poor ene component II affords the corresponding, previously unknown, 3,4-dihydro-2H-pyrans of the general formula III. ##STR10## The reaction can be carried out under the conditions of the hetero-Diels-Alder reactions known per se (D. L. Boger, S. M. Weinreb, loc. cit.).
The reaction of the two components can take place purely thermally, preferably under autogenous pressure, typically at temperatures from 100.degree. C. to 250.degree. C. or with the addition of Lewis acids such as tin tetrachloride, boron trifluoride, titanium tetrachloride, alkylaluminum dihalides, dialkylaluminum halides, magnesium halides, and halides and trifluoromethanesulfonates of the lanthanides. The reaction can be carried out in organic solvents such as aliphatic, aromatic, optionally halogenated, hydrocarbons or ethers or else without solvent. Preferred organic solvents are xylene, toluene, heptane, THF, dioxane, methylene chloride or chloroform.
The reaction typically takes from 6 to 24 h. The resulting 3,4-dihydro-2H-pyrans can be isolated in a manner known per se, for example by thermal separation processes such as distillation, from the reaction solution.
The radicals R.sup.1, R.sup.2 and X in preferred substituted 3,4-dihydro-2H-pyrans of the formula III have the following meanings:
R.sup.1 CH.sub.3 or COCH.sub.3,
R.sup.2 CH.sub.3, 4,8,12-trimethyltridecyl or 4,8,12-trimethyl-3,7,11-tridecatrienyl and
X CN, COOH, COOCH.sub.3, COO--CH.sub.2 --CH.sub.2 --OH, COO--CH.sub.2 --CH.sub.2 --Cl, COO--CH.sub.2 --CH.sub.2 --N(CH.sub.3).sub.2, CHO, CH.sub.2 OH, CH.sub.2 OCH.sub.3 or CH(OCH.sub.3).sub.2 or one of the following structural elements X.sub.1 -X.sub.7. ##STR11##
Examples of combinations of radicals in preferred 3,4-dihydro-2H-pyrans of the formula III are the following:
__________________________________________________________________________Compound R.sup.1 R.sup.2 X__________________________________________________________________________ III.001 CH.sub.3 CH.sub.3 CN - III.002 COCH.sub.3 CH.sub.3 CN - III.003 CH.sub.3 CN R12## - III.004 COCH.sub.3 CN R13## - III.005 CH.sub.3 CN R14## - III.006 COCH.sub.3 CN R15## - III.007 CH.sub.3 CH.sub.3 COOH - III.008 COCH.sub.3 CH.sub.3 COOH - III.009 CH.sub.3 COOH 6## - III.0010 COCH.sub.3 COOH 7## - III.011 CH.sub.3 COOH 8## - III.012 COCH.sub.3 COOH 9## - III.013 CH.sub.3 CH.sub.3 COOCH.sub.3 - III.014 COCH.sub.3 CH.sub.3 COOCH.sub.3 - III.015 CH.sub.3 COOCH.sub.3 - III.016 COCH.sub.3 COOCH.sub.3 - III.017 CH.sub.3 COOCH.sub.3 - III.018 COCH.sub.3 COOCH.sub.3 - III.019 CH.sub.3 CH.sub.3 COO--CH.sub.2 --CH.sub.2 --OH - III.020 COCH.sub.3 CH.sub.3 COO--CH.sub.2 --CH.sub.2 --OH - III.021 CH.sub.3 COO--CH.sub.2 --CH.sub.2 --OH - III.022 COCH.sub.3 COO--CH.sub.2 --CH.sub.2 --OH - III.023 CH.sub.3 COO--CH.sub.2 --CH.sub.2 --OH - III.024 COCH.sub.3 COO--CH.sub.2 --CH.sub.2 --OH - III.025 CH.sub.3 CH.sub.3 COO--CH.sub.2 --CH.sub.2 --Cl - III.026 COCH.sub.3 CH.sub.3 COO--CH.sub.2 --CH.sub.2 --Cl - III.027 CH.sub.3 COO--CH.sub.2 --CH.sub.2 --Cl - III.028 COCH.sub.3 COO--CH.sub.2 --CH.sub.2 --Cl - III.029 CH.sub.3 COO--CH.sub.2 --CH.sub.2 --Cl - III.030 COCH.sub.3 COO--CH.sub.2 --CH.sub.2 --Cl - III.031 CH.sub.3 CH.sub.3 COO--CH.sub.2 --CH.sub.2 --N(CH.su b.3).sub.2 - III.032 COCH.sub.3 CH.sub.3 COO--CH.sub.2 --CH.sub.2 --N(CH.sub.3).su b.2 - III.033 CH.sub.3 COO--CH.sub.2 --CH.sub.2 --N(CH.sub.3).sub.2 - III.034 COCH.sub.3 COO--CH.sub.2 --CH.sub.2 --N(CH.sub.3).sub.2 - III.035 CH.sub.3 COO--CH.sub.2 --CH.sub.2 --N(CH.sub.3).sub.2 - III.036 COCH.sub.3 COO--CH.sub.2 --CH.sub.2 --N(CH.sub.3).sub.2 - III.037 CH.sub.3 CH.sub.3 CHO - III.038 COCH.sub.3 CH.sub.3 CHO - III.039 CH.sub.3 CHO 36## - III.040 COCH.sub.3 CHO 37## - III.041 CH.sub.3 CHO 38## - III.042 COCH.sub.3 CHO 39## - III.043 CH.sub.3 CH.sub.3 CH.sub.2 OH - III.044 COCH.sub.3 CH.sub.3 CH.sub.2 OH - III.045 CH.sub.3 CH.sub.2 OH - III.046 COCH.sub.3 CH.sub.2 OH - III.047 CH.sub.3 CH.sub.2 OH - III.048 COCH.sub.3 CH.sub.2 OH - III.049 CH.sub.3 CH.sub.3 CH.sub.2 OCH.sub.3 - III.050 COCH.sub.3 CH.sub.3 CH.sub.2 OCH.sub.3 - III.051 CH.sub.3 CH.sub.2 OCH.sub.3 - III.052 COCH.sub.3 CH.sub.2 OCH.sub.3 - III.053 CH.sub.3 CH.sub.2 OCH.sub.3 - III.054 COCH.sub.3 CH.sub.2 OCH.sub.3 - III.055 CH.sub.3 CH.sub.3 CH(OCH.sub.3).sub.2 - III.056 COCH.sub.3 CH.sub.3 CH(OCH.sub.3).sub.2 - III.057 CH.sub.3 CH(OCH.sub.3).sub.2 - III.058 COCH.sub.3 CH(OCH.sub.3).sub.2 - III.059 CH.sub.3 CH(OCH.sub.3).sub.2 - III.060 COCH.sub.3 CH(OCH.sub.3).sub.2 - III.061 CH.sub.3 CH.sub.3 X.sub.1 - III.062 COCH.sub.3 CH.sub.3 X.sub.1 - III.063 CH.sub.3 X.sub.1 - III.064 COCH.sub.3 X.sub.1 - III.065 CH.sub.3 X.sub.1 - III.066 COCH.sub.3 X.sub.1 - III.067 CH.sub.3 CH.sub.3 X.sub.2 - III.068 COCH.sub.3 CH.sub.3 X.sub.2 - III.069 CH.sub.3 X.sub.2 - III.070 COCH.sub.3 X.sub.2 - III.071 CH.sub.3 X.sub.2 - III.072 COCH.sub.3 X.sub.2 - III.073 CH.sub.3 CH.sub.3 X.sub.3 - III.074 COCH.sub.3 CH.sub.3 X.sub.3 - III.075 CH.sub.3 X.sub.3 - III.076 COCH.sub.3 X.sub.3 - III.077 CH.sub.3 X.sub.3 - III.078 COCH.sub.3 X.sub.3 - III.079 CH.sub.3 CH.sub.3 X.sub.4 - III.080 COCH.sub.3 CH.sub.3 X.sub.4 - III.081 CH.sub.3 X.sub.4 - III.082 COCH.sub.3 X.sub.4 - III.083 CH.sub.3 X.sub.4 - III.084 COCH.sub.3 X.sub.4 - III.085 CH.sub.3 CH.sub.3 X.sub.5 - III.086 COCH.sub.3 CH.sub.3 X.sub.5 - III.087 CH.sub.3 X.sub.5 - III.088 COCH.sub.3 X.sub.5 - III.089 CH.sub.3 X.sub.5 - III.090 COCH.sub.3 X.sub.5 - III.091 CH.sub.3 CH.sub.3 X.sub.6 - III.092 COCH.sub.3 CH.sub.3 X.sub.6 - III.093 CH.sub.3 X.sub.6 - III.094 COCH.sub.3 C X.sub.6 - III.095 CH.sub.3 X.sub.6 - III.096 COCH.sub.3 X.sub.6 - III.097 CH.sub.3 CH.sub.3 X.sub.7 - III.098 COCH.sub.3 CH.sub.3 X.sub.7 - III.099 CH.sub.3 X.sub.7 - III.100 COCH.sub.3 X.sub.7 - III.101 CH.sub.3 X.sub.7 - III.102 COCH.sub.3 C X.sub.7#__________________________________________________________________________
In the next step of the overall process according to the invention, the 3,4-dihydro-2H-pyrans of the general formula III are reacted with an acid. In this way there is acid-catalyzed elimination of the radical R.sup.1 and liberation of the enol, which in turn tautomerizes to the 5-oxotetrahydropyran of the general formula IV ##STR80##
The substituted 3,4-dihydro-2H-pyrans of the general formula III are reacted with an acid in a manner known per se (J. March, Advanced Organic Chemistry, 4.sup.th edition, 1992, J. Wiley & sons, pp. 373 f.). Acids mean according to the invention Bronsted acids and their aqueous solutions. Examples which may be mentioned are mineral acids such as HCl,H.sub.2 SO.sub.4, HClO.sub.4 and optionally halogenated, i.e. Cl-, Br-, I, F-substituted carboxylic acids such as formic acid, acetic acid, propionic acid, chloroacetic acid, trifluoroacetic acid.
Aqueous acid solutions with a low acid concentration, such as 0.01-12 M, are typically sufficient for converting enol ethers into enols. An example which may be mentioned is a 2M HCl solution.
The reaction is carried out in an organic solvent as mentioned above, preferably in methylene chloride. The duration and temperature of the reaction depend on the radical R.sup.1. The reaction is typically carried out at room temperature for 2 to 12 h.
In preferred substituted 5-oxotetrahydropyrans of the general formula IV, the radicals R.sup.2 and X have the following meanings:
R.sup.2 CH.sub.3, 4,8,12-trimethyltridecyl or 4,8,12-trimethyl-3,7,11-tridecatrienyl and
X CN, COOH, COOCH.sub.3, COO--CH.sub.2 --CH.sub.2 --OH, COO--CH.sub.2 --CH.sub.2 --Cl, COO--CH.sub.2 --CH.sub.2 --N(CH.sub.3).sub.2, CHO, CH.sub.2 OH, CH.sub.2 OCH.sub.3 or CH(OCH.sub.3).sub.2 or one of the structural elements X.sub.1 -X.sub.7 as mentioned above for the substituted 3,4-dihydro-2H-pyrans of the formula III.
Examples of radical combinations in preferred substituted 5-oxotetrahydropyrans of the general formula IV are the following:
__________________________________________________________________________Compound R.sup.2 X__________________________________________________________________________ IV.001 CH.sub.3 CN - IV.002 CN R81## - IV.003 CN R82## - IV.004 CH.sub.3 COOH - IV.005 COOH 3## - IV.006 COOH 4## - IV.007 CH.sub.3 COOCH.sub.3 - IV.008 COOCH.sub.3 - IV.009 COOCH.sub.3 - IV.010 CH.sub.3 COO--CH.sub.2 --CH.sub.2 --OH - IV.011 COO--CH.sub.2 --CH.sub.2 --OH - IV.012 COO--CH.sub.2 --CH.sub.2 --OH - IV.013 CH.sub.3 COO--CH.sub.2 --CH.sub.2 --Cl - IV.014 COO--CH.sub.2 --CH.sub.2 --Cl - IV.015 COO--CH.sub.2 --CH.sub.2 --Cl - IV.016 CH.sub.3 COO--CH.sub.2 --CH.sub.2 --N(CH.sub.3).sub.2 - IV.017 COO--CH.sub.2 --CH.sub.2 --N(CH.sub.3 ).sub.2 - IV.018 COO--CH.sub.2 --CH.sub.2 --N(CH.sub.3 ).sub.2 - IV.019 CH.sub.3 CHO - IV.020 CHO 93## - IV.021 CHO 94## - IV.022 CH.sub.3 CH.sub.2 OH - IV.023 CH.sub.2 OH - IV.024 CH.sub.2 OH - IV.025 CH.sub.3 CH.sub.2 OCH.sub.3 - IV.026 CH.sub.2 OCH.sub.3 - IV.027 CH.sub.2 OCH.sub.3 - IV.028 CH.sub.3 CH(OCH.sub.3).sub.2 - IV.029 CH(OCH.sub.3).sub.2 - IV.030 CH(OCH.sub.3).sub.2 - IV.031 CH.sub.3 X.sub.1 - IV.032 X.sub.1 # - IV.033 X.sub.1 # - IV.034 CH.sub.3 X.sub.2 - IV.035 X.sub.2 # - IV.036 X.sub.2 # - IV.037 CH.sub.3 X.sub.3 - IV.038 X.sub.3 # - IV.039 X.sub.3 # - IV.040 CH.sub.3 X.sub.4 - IV.041 X.sub.4 # - IV.042 X.sub.4 # - IV.043 CH.sub.3 X.sub.5 - IV.044 X.sub.5 # - IV.045 X.sub.5 # - IV.046 CH.sub.3 X.sub.6 - IV.047 X.sub.6 # - IV.048 X.sub.6 # - IV.049 CH.sub.3 X.sub.7 - IV.050 X.sub.7 # - IV.051 X.sub.7##__________________________________________________________________________
In the next step of the overall process according to the invention, the 5-oxotetrahydropyrans of the general formula IV are reacted with substituted vinyl ketones of the general formula V in a Robinson annulation (J. March, Advanced Organic Chemistry, 4.sup.th edition, 1992, J. Wiley & sons, pp. 943-944) ##STR115##
The radicals R.sup.4, R.sup.5 and R.sup.6 are, independently of one another, hydrogen or a C.sub.1 -C.sub.4 -alkyl radical as described above for R.sup.1, in particular methyl. Preferred substituted vinyl ketones of the general formula V are
4-methyl-4-hexen-3-one (R.sup.4 =R.sup.5 =R.sup.6 =methyl),
4-hexen-3-one (R.sup.4 =hydrogen; R.sup.5 =R.sup.6 =methyl),
3-methyl-3-penten-2-one (R.sup.4 =R.sup.5 =methyl, R.sup.6 =hydrogen) and
3-penten-2-one (R.sup.4 =R.sup.6 =hydrogen, R.sup.5 =methyl).
The Robinson annulation can be carried out in a manner known per se (M. E. Jung, Tetrahedron 1976, 32, 3-31; T. Sato et al. Tetrahedron Letters 1990, 31, 1581-1584 and publications cited therein, and F. Eicher, K. Wanner, Arch. der Pharmazie 1984, 317, 958-962).
In a preferred embodiment, the reaction is carried out by the enamine method known per se (G. Storck et al., J. Am. Chem. Soc. 1963, 85, 207). This entails firstly reacting the substituted 5-oxotetrahydropyrans of the general formula IV with secondary amines of the formula VIII
HN(R.sup.9).sub.2 VIII
to give the corresponding enamines of the formula IX ##STR116##
The two R.sup.9 radicals are identical or different C.sub.1 -C.sub.4 -alkyl radicals as mentioned above for R.sup.1, preferably methyl or ethyl, or a phenyl radical or the two R.sup.9 radicals represent a C.sub.2 -C.sub.6 -alkylene radical, such as ethylene, propylene, butylene, pentylene, neopentylene or hexylene, or a C.sub.2 -C.sub.6 -alkylene radical where one or two methylene groups are replaced by oxygen, such as --CH.sub.2 --O--CH.sub.2 -- or --CH.sub.2 --CH.sub.2 --O--CH.sub.2 --CH.sub.2 -- bridge, to form a cyclic amine.
Preferred secondary amines of the formula VIII are accordingly amines such as dimethylamine, diethylamine, pyrrolidine or morpholine, with pyrrolidine or morpholine being particularly preferred.
This entails reacting the substituted 5-oxotetrahydropyrans of the general formula IV in an organic solvent as mentioned above in the case of the reaction to give the compound of the formula III, firstly with the secondary amine of the formula VIII and a water-binding desiccant such as MgSO.sub.4, Na.sub.2 SO.sub.4 or TiCl.sub.4 to give the enamine of the formula IX. In another embodiment, the water which is formed can be removed by azeotropic distillation with the addition of entrainers such as benzene, toluene, pentane or CH.sub.2 Cl.sub.2. The temperature of the reaction is not critical and is typically room temperature on use of desiccants. The reaction typically takes 12 to 24 h.
The enamines of the formula IX formed from IV are then reacted in a Michael addition with the substituted vinyl ketones of the formula V ##STR117## to give the corresponding keto enamines of the formula X ##STR118## in a manner known per se (Nelson et al., J. Org. Chem. 1969, 34, 1225).
The keto enamines of the formula X are then converted into the corresponding diketone compounds of the formula XI ##STR119## by addition of acids, for example mineral acids such as hydrochloric acid or sulfuric acid, or aqueous solutions thereof, and the diketones of the formula XI formed as intermediates are converted into the substituted chromen-6-one derivatives of the general formula VI by addition of a base such as diisopropylethylamine, lithium diethylamide or sodium C.sub.1 -C.sub.4 -alcoholates such as sodium methoxide or sodium ethoxide in a manner known per se (M. E. Jung, Tetrahedron 1976, 32, 3; R. E. Ganley, Synthesis 1976, 777).
The radicals R.sup.2, R.sup.4, R.sup.5, R.sup.6 and X in preferred substituted chromen-6-one derivatives of the general formula VI have the following meanings:
R.sup.2 CH.sub.3, 4,8,12-trimethyltridecyl or 4,8,12-trimethyl-3,7,11-tridecatrienyl,
R.sup.4, R.sup.5 and R.sup.6 independently of one another hydrogen or CH.sub.3 and
X CN, COOH, COOCH.sub.3, COO--CH.sub.2 --CH.sub.2 --OH, COO--CH.sub.2 --CH.sub.2 --Cl, COO--CH.sub.2 --CH.sub.2 --N(CH.sub.3).sub.2, CHO, CH.sub.2 OH, CH.sub.2 OCH.sub.3 or CH (OCH.sub.3).sub.2 or one of the structural elements X.sub.1 -X.sub.7, as mentioned above for the substituted 3,4-dihydro-2H-pyrans of the formula III.
Examples of radical combinations in preferred chromen-6-one derivatives of the formula VI are the following:
__________________________________________________________________________Compound R.sup.2 R.sup.4 R.sup.5 R.sup.6 X__________________________________________________________________________VI.001 CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3 CN VI.002 CH.sub.3 H CH.sub.3 CH.sub.3 CN VI.003 CH.sub.3 CH.sub.3 CH.sub.3 H CN VI.004 CH.sub.3 H CH.sub.3 H CN - VI.005 CH.sub.3 CH.sub.3 CH.sub.3 CN - VI.006 H CH.sub.3 CH.sub.3 CN - VI.007 CH.sub.3 CH.sub.3 H CN - VI.008 H CH.sub.3 H CN - VI.009 CH.sub.3 CH.sub.3 CH.sub.3 CN - VI.010 H CH.sub.3 CH.sub.3 CN - VI.011 CH.sub.3 CH.sub.3 H CN - VI.012 H CH.sub.3 H CN - VI.013 CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3 COOH VI.014 CH.sub.3 H CH.sub.3 CH.sub.3 COOH VI.015 CH.sub.3 CH.sub.3 CH.sub.3 H COOH VI.016 CH.sub.3 H CH.sub.3 H COOH - VI.017 CH.sub.3 CH.sub.3 CH.sub.3 COOH - VI.018 H CH.sub.3 CH.sub.3 COOH - VI.019 CH.sub.3 CH.sub.3 H COOH - VI.020 H CH.sub.3 H COOH - VI.021 CH.sub.3 CH.sub.3 CH.sub.3 COOH - VI.022 H CH.sub.3 CH.sub.3 COOH - VI.023 CH.sub.3 CH.sub.3 H COOH - VI.024 H CH.sub.3 H COOH - VI.025 CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3 COOCH.sub.3 VI.026 CH.sub.3 H CH.sub.3 CH.sub.3 COOCH.sub.3 VI.027 CH.sub.3 CH.sub.3 CH.sub.3 H COOCH.sub.3 VI.028 CH.sub.3 H CH.sub.3 H COOCH.sub.3 - VI.029 CH.sub.3 CH.sub.3 CH.sub.3 COOCH.sub.3 - VI.030 H CH.sub.3 CH.sub.3 COOCH.sub.3 - VI.031 CH.sub.3 CH.sub.3 H COOCH.sub.3 - VI.032 H CH.sub.3 H COOCH.sub.3 - VI.033 CH.sub.3 CH.sub.3 CH.sub.3 COOCH.sub.3 - VI.034 H CH.sub.3 CH.sub.3 COOCH.sub.3 - VI.035 CH.sub.3 CH.sub.3 H COOCH.sub.3 - VI.036 H CH.sub.3 H COOCH.sub.3 - VI.037 CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3 COO--CH.sub. 2 --CH.sub.2 --OH VI.038 CH.sub.3 H CH.sub.3 CH.sub.3 COO--CH.sub.2 --CH.sub.2 --OH VI.039 CH.sub.3 CH.sub.3 CH.sub.3 H COO--CH.sub.2 --CH.sub.2 --OH VI.040 CH.sub.3 H CH.sub.3 H COO--CH.sub.2 --CH.sub.2 --OH - VI.041 CH.sub.3 CH.sub.3 CH.sub.3 COO--CH.sub.2 --CH.sub.2 --OH - VI.042 H CH.sub.3 CH.sub.3 COO--CH.sub.2 --CH.sub.2 --OH - VI.043 CH.sub.3 CH.sub.3 H COO--H.sub.2 --CH.sub.2 --OH - VI.044 H CH.sub.3 H COO--CH.sub.2 --CH.sub.2 --OH - VI.045 CH.sub.3 CH.sub.3 CH.sub.3 COO--CH.sub.2 --CH.sub.2 --OH - VI.046 H CH.sub.3 CH.sub.3 COO--CH.sub.2 --CH.sub.2 --OH - VI.047 CH.sub.3 CH.sub.3 H COO--CH.sub.2 --CH.sub.2 --OH - VI.048 H CH.sub.3 H COO--CH.sub.2 --CH.sub.2 --OH - VI.049 CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3 COO--CH.sub.2 --CH.sub.2 --Cl VI.050 CH.sub.3 H CH.sub.3 CH.sub.3 COO--CH.sub.2 --CH.sub.2 --Cl VI.051 CH.sub.3 CH.sub.3 CH.sub.3 H COO--CH.sub.2 --CH.sub.2 --Cl VI.052 CH.sub.3 H CH.sub.3 H COO--CH.sub.2 --CH.sub.2 --Cl - VI.053 CH.sub.3 CH.sub.3 CH.sub.3 COO--CH.sub.2 --CH.sub.2 --Cl - VI.054 H CH.sub.3 CH.sub.3 COO--CH.sub.2 --CH.sub.2 --Cl - VI.055 CH.sub.3 CH.sub.3 H COO--CH.sub.2 --CH.sub.2 --Cl - VI.056 H CH.sub.3 H COO--CH.sub.2 --CH.sub.2 --Cl - VI.057 CH.sub.3 CH.sub.3 CH.sub.3 COO--CH.sub.2 --CH.sub.2 --Cl - VI.058 H CH.sub.3 CH.sub.3 COO--CH.sub.2 --CH.sub.2 --Cl - VI.059 CH.sub.3 CH.sub.3 H COO--CH.sub.2 --CH.sub.2 --Cl - VI.060 H CH.sub.3 H COO--CH.sub.2 --CH.sub.2 --Cl - VI.061 CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3 COO--CH.sub.2 --CH.sub.2 --N(CH.sub.3).sub.2 VI.062 CH.sub.3 H CH.sub.3 CH.sub.3 COO--CH.sub.2 --CH.sub.2 --N(CH.sub. 3).sub.2 VI.063 CH.sub.3 CH.sub.3 CH.sub.3 H COO--CH.sub.2 --CH.sub.2 --N(CH.sub. 3).sub.2 VI.064 CH.sub.3 H CH.sub.3 H COO--CH.sub.2 --CH.sub.2 --N(CH.sub.3).sub. 2 - VI.065 CH.sub.3 CH.sub.3 CH.sub.3 COO--CH.sub.2 --CH.sub.2 --N(CH.sub.3).sub.2 - VI.066 H CH.sub.3 CH.sub.3 COO--CH.sub.2 --CH.sub.2 --N(CH.sub.3).sub.2 - VI.067 CH.sub.3 CH.sub.3 H COO--CH.sub.2 --CH.sub.2 --N(CH.sub.3).sub.2 - VI.068 H CH.sub.3 H COO--CH.sub.2 --CH.sub.2 --N(CH.sub.3).sub.2 - VI.069 CH.sub.3 CH.sub.3 CH.sub.3 COO--CH.sub.2 --CH.sub.2 --N(CH.sub.3).sub.2 - VI.070 H CH.sub.3 CH.sub.3 COO--CH.sub.2 --CH.sub.2 --N(CH.sub.3).sub.2 - VI.071 CH.sub.3 CH.sub.3 H COO--CH.sub.2 --CH.sub.2 --N(CH.sub.3).sub.2 - VI.072 H CH.sub.3 H COO--CH.sub.2 --CH.sub.2 --N(CH.sub.3 - VI.073 CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3 CHO VI.074 CH.sub.3 H CH.sub.3 CH.sub.3 CHO VI.075 CH.sub.3 CH.sub.3 CH.sub.3 H CHO VI.076 CH.sub.3 H CH.sub.3 H CHO - VI.077 CH.sub.3 CH.sub.3 CH.sub.3 CHO - VI.078 H CH.sub.3 CH.sub.3 CHO - VI.079 CH.sub.3 CH.sub.3 H CHO - VI.080 H CH.sub.3 H CHO - VI.081 CH.sub.3 CH.sub.3 CH.sub.3 CHO - VI.082 H CH.sub.3 CH.sub.3 CHO - VI.083 CH.sub.3 CH.sub.3 H CHO - VI.084 H CH.sub.3 H CHO - VI.085 CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.2 OH VI.086 CH.sub.3 H CH.sub.3 CH.sub.3 CH.sub.2 OH VI.087 CH.sub.3 CH.sub.3 CH.sub.3 H CH.sub.2 OH VI.088 CH.sub.3 H CH.sub.3 H CH.sub.2 OH - VI.089 CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.2 OH - VI.090 H CH.sub.3 CH.sub.3 CH.sub.2 OH - VI.091 CH.sub.3 CH.sub.3 H CH.sub.2 OH - VI.092 H CH.sub.3 H CH.sub.2 OH - VI.093 CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.2 OH - VI.094 H CH.sub.3 CH.sub.3 CH.sub.2 OH - VI.095 CH.sub.3 CH.sub.3 H CH.sub.2 OH - VI.096 H CH.sub.3 H CH.sub.2 OH - VI.097 CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.2 OCH.sub.3 VI.098 CH.sub.3 H CH.sub.3 CH.sub.3 CH.sub.2 OCH.sub.3 VI.099 CH.sub.3 CH.sub.3 CH.sub.3 H CH.sub.2 OCH.sub.3 VI.100 CH.sub.3 H CH.sub.3 H CH.sub.2 OCH.sub.3 - VI.101 CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.2 OCH.sub.3 - VI.102 H CH.sub.3 CH.sub.3 CH.sub.2 OCH.sub.3 - VI.103 CH.sub.3 CH.sub.3 H CH.sub.2 OCH.sub.3 - VI.104 H CH.sub.3 H CH.sub.2 OCH.sub.3 - VI.105 CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.2 OCH.sub.3 - VI.106 H CH.sub.3 CH.sub.3 CH.sub.2 OCH.sub.3 - VI.107 CH.sub.3 CH.sub.3 H CH.sub.2 OCH.sub.3 - VI.108 H CH.sub.3 H CH.sub.2 OCH.sub.3 - VI.109 CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3 CH(OCH.sub.3).sub.2 VI.110 CH.sub.3 H CH.sub.3 CH.sub.3 CH(OCH.sub.3).sub.2 VI.111 CH.sub.3 CH.sub.3 CH.sub.3 H CH(OCH.sub.3).sub.2 VI.112 CH.sub.3 H CH.sub.3 H CH(OCH.sub.3).sub.2 - VI.113 CH.sub.3 CH.sub.3 CH.sub.3 CH(OCH.sub.3).sub.2 - VI.114 H CH.sub.3 CH.sub.3 CH(OCH.sub.3).sub.2 - VI.115 CH.sub.3 CH.sub.3 H CH(OCH.sub.3).sub.2 - VI.116 H CH.sub.3 H CH(OCH.sub.3).s ub.2 - VI.117 CH.sub.3 CH.sub.3 CH.sub.3 CH(OCH.sub.3).sub.2 - VI.118 H CH.sub.3 CH.sub.3 CH(OCH.sub.3).sub.2 - VI.119 CH.sub.3 CH.sub.3 H CH(OCH.sub.3).sub.2 - VI.120 H CH.sub.3 H CH(OCH.sub.3).s ub.2 - VI.121 CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3 X.sub.1 VI.122 CH.sub.3 H CH.sub.3 CH.sub.3 x1 VI.123 CH.sub.3 CH.sub.3 CH.sub.3 H X.sub.1 VI.124 CH.sub.3 H CH.sub.3 H X.sub.1 - VI.125 CH.sub.3 CH.sub.3 CH.sub.3 x1 - VI.126 H CH.sub.3 CH.sub.3 x1 - VI.127 CH.sub.3 CH.sub.3 H X.sub.1 - VI.128 H CH.sub.3 H X.sub.1 - VI.129 CH.sub.3 CH.sub.3 CH.sub.3 X.sub.1 - VI.130 H CH.sub.3 CH.sub.3 X.sub.1 - VI.131 CH.sub.3 CH.sub.3 H X.sub.1 - VI.132 H CH.sub.3 H X.sub.1 - VI.133 CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3 X.sub.2 VI.134 CH.sub.3 H CH.sub.3 CH.sub.3 X.sub.2 VI.135 CH.sub.3 CH.sub.3 CH.sub.3 H X.sub.2 VI.136 CH.sub.3 H CH.sub.3 H X.sub.2 - VI.137 CH.sub.3 CH.sub.3 CH.sub.3 X.sub.2 - VI.138 H CH.sub.3 CH.sub.3 x2 - VI.139 CH.sub.3 CH.sub.3 H X.sub.2 - VI.140 H CH.sub.3 H X.sub.2 - VI.141 CH.sub.3 CH.sub.3 CH.sub.3 X.sub.2 - VI.142 H CH.sub.3 CH.sub.3 X.sub.2 - VI.143 CH.sub.3 CH.sub.3 H X.sub.2 - VI.144 H CH.sub.3 H X.sub.2 - VI.145 CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3 X.sub.3 VI.146 CH.sub.3 H CH.sub.3 CH.sub.3 X.sub.3 VI.147 CH.sub.3 CH.sub.3 CH.sub.3 H X.sub.3 VI.148 CH.sub.3 H CH.sub.3 H X.sub.3 - VI.149 CH.sub.3 CH.sub.3 CH.sub.3 X.sub.3 - VI.150 H CH.sub.3 CH.sub.3 X.sub.3 - VI.151 CH.sub.3 CH.sub.3 H X.sub.3 - VI.152 H CH.sub.3 H X.sub.3 - VI.153 CH.sub.3 CH.sub.3 CH.sub.3 X.sub.3 - VI.154 H CH.sub.3 CH.sub.3 X.sub.3 - VI.155 CH.sub.3 CH.sub.3 H X.sub.3 - VI.156 H CH.sub.3 H X.sub.3 - VI.157 CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3 X.sub.4 VI.158 CH.sub.3 H CH.sub.3 CH.sub.3 X.sub.4 VI.159 CH.sub.3 CH.sub.3 CH.sub.3 H X.sub.4 VI.160 CH.sub.3 H CH.sub.3 H X.sub.4 - VI.161 CH.sub.3 CH.sub.3 CH.sub.3 x4 - VI.162 H CH.sub.3 CH.sub.3 x4 - VI.163 CH.sub.3 CH.sub.3 H X.sub.4 - VI.164 H CH.sub.3 H X.sub.4 - VI.165 CH.sub.3 CH.sub.3 CH.sub.3 X.sub.4 - VI.166 H CH.sub.3 CH.sub.3 X.sub.4 - VI.167 CH.sub.3 CH.sub.3 H X.sub.4 - VI.168 H CH.sub.3 H x4 - VI.169 CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3 X.sub.5 VI.170 CH.sub.3 H CH.sub.3 CH.sub.3 X.sub.5 VI.171 CH.sub.3 CH.sub.3 CH.sub.3 H X.sub.5 VI.172 CH.sub.3 H CH.sub.3 H X.sub.5 - VI.173 CH.sub.3 CH.sub.3 CH.sub.3 X.sub.5 - VI.174 H CH.sub.3 CH.sub.3 X.sub.5 - VI.175 CH.sub.3 CH.sub.3 H X.sub.5 - VI.176 H CH.sub.3 H X.sub.5 - VI.177 CH.sub.3 CH.sub.3 CH.sub.3 X.sub.5 - VI.178 H CH.sub.3 CH.sub.3 X.sub.5 - VI.179 CH.sub.3 CH.sub.3 H X.sub.5 - VI.180 H CH.sub.3 H X.sub.5 - VI.181 CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3 X.sub.6 VI.182 CH.sub.3 H CH.sub.3 CH.sub.3 X.sub.6 VI.183 CH.sub.3 CH.sub.3 CH.sub.3 H X.sub.6 VI.184 CH.sub.3 H CH.sub.3 H X.sub.6 - VI.185 CH.sub.3 CH.sub.3 CH.sub.3 X.sub.6 - VI.186 H CH.sub.3 CH.sub.3 X.sub.6 - VI.187 CH.sub.3 CH.sub.3 H X.sub.6 - VI.188 H CH.sub.3 H X.sub.6 - VI.189 CH.sub.3 CH.sub.3 CH.sub.3 X.sub.6 - VI.190 CH.sub.3 CH.sub.3 X.sub.6 - VI.191 CH.sub.3 CH.sub.3 H X.sub.6 - VI.192 H CH.sub.3 H X.sub.6 - VI.193 CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3 X.sub.7 VI.194 CH.sub.3 H CH.sub.3 CH.sub.3 X.sub.7 VI.195 CH.sub.3 CH.sub.3 CH.sub.3 H X.sub.7 VI.196 CH.sub.3 H CH.sub.3 H X.sub.7 - VI.197 CH.sub.3 CH.sub.3 CH.sub.3 x7 - VI.198 H CH.sub.3 CH.sub.3 X.sub.7 - VI.199 CH.sub.3 CH.sub.3 H X.sub.7 - VI.200 H CH.sub.3 H X.sub.7 - VI.201 CH.sub.3 CH.sub.3 CH.sub.3 X.sub.7 - VI.202 H CH.sub.3 CH.sub.3 x7 - VI.203 CH.sub.3 CH.sub.3 H X.sub.7 - VI.204 H CH.sub.3 H X.sub.7__________________________________________________________________________
In the last step of the process according to the invention, the chromen-6-one derivatives of the general formula VI are dehydrogenated by addition of dehydrogenating agents such as Pd(C), MnO.sub.2, S, Se or DDQ (dichlorodicyanoquinone; 4,5-dichloro-3,6-dioxo-1,4-cyclohexadiene-1,2-dicarbonitrile) in a manner known per se to give the substituted chromans of the general formula VII (R.P. Fu, R. G. Harvey, Chem. Rev. 1978, 78, 317).
The process according to the invention is a novel process for preparing chroman derivatives of the general formula VII. The process moreover makes use of low-cost starting materials. In addition, the process avoids the well-known problem of regioselectivity in electrophilic substitutions on electron-rich aromatic systems in prior art processes and makes it possible to construct a flexible substituent pattern on the aromatic moiety in the chroman structure. Besides this, the process proceeds via novel, easily handled intermediates which in turn are valuable intermediates for novel pharmaceutical agents, flavorings and fragrances, and vitamins and food additives.
The following examples illustrate the invention.





EXAMPLE 1
Preparation of 2-methyl-2-methoxycarbonyl-5-methoxy-3,4-dihydro-2H-pyran (IIIa) ##STR256## 1a) Preparation without addition of Lewis acids
0.2 mol of .alpha.-methoxyacrolein was dissolved in 100 ml of xylene and then 0.2 mol of methyl methacrylate was added. The mixture was stirred at 180.degree. C. under autogenous pressure for 12 h. Vacuum distillation of the mixture resulted in isolation of 0.08 mol (40% of theory) of the product 2-methyl-2-methoxycarbonyl-5-methoxy-3,4-dihydro-2H-pyran as the colorless oil.
MS(EI): 186 (M+, 48%), 155 (33%), 127 (62%)
.sup.13 C-NMR: 174.5, 140.5, 122.9, 76.1, 55.0, 52.4, 29.8, 25.1, 19.9
1b) Preparation with addition of Lewis acids
0.2 mol of .alpha.-methoxyacrolein was dissolved in 100 ml of xylene. Then, while cooling, 10 mmol of tin tetrachloride and then 0.2 mol of methyl methacrylate were added, and the mixture was stirred at 120.degree. C. under autogenous pressure for 12 h. Vacuum distillation of the mixture resulted in isolation of 32% of theory of the product of 2-methyl-2-methoxycarbonyl-5-methoxy-3,4-dihydro-2H-pyran as a pale yellow oil. See 1a for physical data.
EXAMPLE 2
Preparation of 2-methyl-2-formyl-5-methoxy-3,4-dihydro-2H-pyran (IIIb) ##STR257##
0.2 mol of .alpha.-methoxyacrolein was dissolved in 100 ml of xylene and then 0.2 mol of methacrolein was added. The mixture was stirred at 180.degree. C. under autogenous pressure for 12 h. Vacuum distillation of the mixture resulted in isolation of 0.11 mol (55% of theory) of the product 2-methyl-2-formyl-5-methoxy-3,4-dihydro-2H-pyran as a colorless oil.
MS(CI): 156 (M+, 12%), 141 (14%), 87 (100%)
EXAMPLE 3
Preparation of 2-methyl-2-hydroxymethyl-5-methoxy-3,4-dihydro-2H-pyran (IIIc) ##STR258##
0.2 mol of .alpha.-methoxyacrolein was dissolved in 100 ml of xylene and then 0.2 ml of methallyl alcohol was added. The mixture was stirred at 180.degree. C. under autogenous pressure for 12 h. Vacuum distillation of the mixture resulted in isolation of 0.15 mol (75% of theory) of the product 2-methyl-2-hydroxymethyl-5-methoxy-3,4-dihydro-2H-pyran as a colorless oil.
MS(CI): 158 (M+, 4%), 141 (9%), 127 (33%), 87 (100%)
EXAMPLE 4
Preparation of 2-hydroxyethyl 2-methyl-5-methoxy-3,4-dihydro-2H-pyran-2-carboxylate (IIId) ##STR259##
0.2 mol of .alpha.-methoxyacrolein was dissolved in 100 ml of xylene and then 0.2 mol of 2-hydroxyethyl methacrylate was added. The mixture was stirred at 180.degree. C. under autogenous pressure for 12 h. Vacuum distillation of the mixture resulted in isolation of the product 2-hydroxyethyl 2-methyl-5-methoxy-3,4-dihydro-2H-pyran- 2-carboxylate as a colorless oil in a yield of 48%.
MS(EI): 216 (M+, 88%), 127 (100%), 185 (10%), 154 (9%)
EXAMPLE 5
Preparation of 2-chloroethyl 2-methyl-5-methoxy-3,4-dihydro-2H-pyran-2-carboxylate (IIIe) ##STR260##
0.2 mol of .alpha.-methoxyacrolein was dissolved in 100 ml of xylene and then 0.2 mol of 2-chloroethyl methacrylate was added. The mixture was stirred at 180.degree. C. under autogenous pressure for 12 h. Vacuum distillation of the mixture resulted in isolation of the product 2-chloroethyl 2-methyl-5-methoxy-3,4-dihydro-2H-pyran-2-carboxylate as a colorless oil in a yield of 45%.
MS(EI): 234 (M+, 12%), 199 (27%), 113 (100%)
EXAMPLE 6
Preparation of 2-dimethylaminoethyl 2-methyl-5-methoxy-3,4-dihydro-2H-pyran-2-carboxylate (IIIf) ##STR261##
0.2 mol of .alpha.-methoxyacrolein was dissolved in 100 ml of xylene and then 0.2 mol of 2-dimethylaminoethyl methacrylate was added. The mixture was stirred at 180.degree. C. under autogenous pressure for 12 h. Column chromatography of the mixture resulted in isolation of the product 2-dimethylaminoethyl 2-methyl-5-methoxy-3,4-dihydro-2H-pyran-2-carboxylate in a yield of 52%.
NMR: .delta.(.sup.13 C) in [ppm]: 198.1; 173.6; 140.5; 123.1; 62.6; 57.2; 55.1; 45.2; 29.8; 24.5; 21.6
EXAMPLE 7
Preparation of 2-chloroethyl 2-methyl-5-oxotetrahydropyran-2-carboxylate (IVe) by hydrolyzing 2-chloroethyl 2-methyl-5-methoxy-3,4-dihydro-2H-pyran-2-carboxylate (IIIg) ##STR262##
3.72 g (20 mmol) of 2-chloroethyl 2-methyl-5-methoxy-3,4-dihydro-2H-pyran-2-carboxylate (IIIe) were dissolved in 20 ml of methylene chloride and, at RT, 20 ml of aqueous HCl solution (2M) were added and the mixture was stirred until precursor was no longer detectable by a TLC check (4 h). The phases were separated. After drying of the organic phase and removal of the solvent, 3.20 g (74%) of 2-chloroethyl 2-methyl-5-oxo-tetrahydropyran-2-carboxylate (IVe) remain as a yellow oil.
MS(EI): 220 (M+, 10%), 151 (4%), 113 (100%)
Claims
  • 1. A process for preparing substituted chroman derivatives of the general formula VII, ##STR263## where X is the group --CN, --COOR.sup.3, --CHO, --CH.sub.2 OR.sup.7 or --CH(OR.sup.8).sub.2,
  • R.sup.2 is a C.sub.1 -C.sub.23 -alkyl, C.sub.2 -C.sub.23 -alkenyl, C.sub.6 -C.sub.18 -aryl or C.sub.7 -C.sub.18 -aralkyl radical,
  • R.sup.3 is hydrogen, a C.sub.1 -C.sub.4 -alkyl radical, a C.sub.1 -C.sub.4 -haloalkyl radical, a C.sub.1 -C.sub.4 -hydroxyalkyl radical or a C.sub.1 -C.sub.4 -aminoalkyl radical,
  • R.sup.4, R.sup.5, R.sup.6 are, independently of one another, hydrogen or a C.sub.1 -C.sub.4 -alkyl radical,
  • R.sup.7 is hydrogen or a C.sub.1 -C.sub.4 -alkyl radical,
  • R.sup.8 is a C.sub.1 -C.sub.4 -alkyl radical, or the two radicals are a C.sub.2 -C.sub.6 -alkylene radical which links the two oxygen atoms to form a cyclic acetal and is optionally branched or may carry one or two carboxyl groups, cyclohexyl or phenyl radicals,
  • which comprises, in a first step, reacting substituted acroleins of the general formula I, ##STR264## where R.sup.1 is a C.sub.1 -C.sub.4 -alkyl, C.sub.6 -C.sub.18 -aryl, C.sub.7 -C.sub.18 -aralkyl, C.sub.1 -C.sub.4 -acyl, a halogenated C.sub.1 -C.sub.4 -acyl radical or another acid-labile protective group for the hydroxyl group,
  • with acrylonitriles, acrylates, acroleins, acrolein acetals, allyl alcohols or allyl ethers of the general formula II ##STR265## to give the corresponding 3,4-dihydro-2H-pyrans of the general formula III ##STR266## and, in a second step, reacting the latter with an acid to give the corresponding 5-oxotetrahydropyrans of the general formula IV ##STR267## and, in a third step, reacting the latter with substituted vinyl ketones of the general formula V ##STR268## to give the corresponding chromen-6-one derivatives of the general formula VI ##STR269## and, in a 4th step, dehydrogenating the latter to give the substituted chroman derivatives of the general formula VII.
  • 2. A substituted 3,4-dihydro-2H-pyran of the formula III, ##STR270## where R.sup.1 is a C.sub.1 -C.sub.4 -alkyl, C.sub.6 -C.sub.18 -aryl, C.sub.7 -C.sub.18 -aralkyl, C.sub.1 -C.sub.4 -acyl, a halogenated C.sub.1 -C.sub.4 -acyl radical or another acid-labile protective group for the hydroxyl group,
  • X is the group --CN, --COOR.sup.3, --CHO, --CH.sub.2 OR.sup.7 or --CH(OR.sup.8).sub.2,
  • R.sup.2 is a C.sub.1 -C.sub.23 -alkyl, C.sub.2 -C.sub.23 -alkenyl, C.sub.6 -C.sub.18 -aryl or C.sub.7 -C.sub.18 -aralkyl radical,
  • R.sup.3 is hydrogen, a C.sub.1 -C.sub.4 -alkyl radical, a C.sub.1 -C.sub.4 -haloalkyl radical, a C.sub.1 -C.sub.4 -hydroxyalkyl radical or a C.sub.1 -C.sub.4 -aminoalkyl radical,
  • R.sup.7 is hydrogen or a C.sub.1 -C.sub.4 -alkyl radical,
  • R.sup.8 is a C.sub.1 -C.sub.4 -alkyl radical, or the two radicals are a C.sub.2 -C.sub.6 -alkylene radical which links the two oxygen atoms to form a cyclic acetal and is optionally branched or may carry one or two carboxyl groups, cyclohexyl or phenyl radicals.
  • 3. A substituted 3,4-dihydro-2H-pyran of the formula III as claimed in claim 2, where the substituents have the following meanings:
  • R.sup.1 CH.sub.3 or COCH.sub.3,
  • R.sup.2 CH.sub.3, 4,8,12-trimethyltridecyl or 4,8,12-trimethyl-3,7,11-tridecatrienyl and
  • X CN, COOH, COOCH.sub.3, COO--CH.sub.2 --CH.sub.2 --OH, COO--CH.sub.2 --CH.sub.2 --Cl, COO--CH.sub.2 --CH.sub.2 --N(CH.sub.3).sub.2, CHO, CH.sub.2 OH, CH.sub.2 OCH.sub.3 or CH(OCH.sub.3).sub.2 or one of the following structural elements X.sub.1 -X.sub.7. ##STR271##
  • 4. A process for preparing substituted 3,4-dihydro-2H-pyrans of the general formula III as claimed in claim 2, which comprises reacting substituted acroleins of the general formula I, with acrylonitriles, acrylates, acroleins, acrolein acetals, allyl alcohols or allyl ethers of the general formula II, ##STR272##
  • 5. A substituted 5-oxotetrahydropyran of the formula IV, where
  • X is the group --CN, --COOR.sup.3, --CHO, --CH.sub.2 OR.sup.7 or --CH(OR.sup.8).sub.2,
  • R.sup.2 is a C.sub.1 -C.sub.23 -alkyl, C.sub.2 -C.sub.23 -alkenyl, C.sub.6 -C.sub.18 -aryl or C.sub.7 -C.sub.18 -aralkyl radical,
  • R.sup.3 is hydrogen, a C.sub.1 -C.sub.4 -alkyl radical, a C.sub.1 -C.sub.4 -haloalkyl radical, a C.sub.1 -C.sub.4 -hydroxyalkyl radical or a C1-C4-aminoalkyl radical,
  • R.sup.7 is hydrogen or a C.sub.1 -C.sub.4 -alkyl radical,
  • R.sup.8 is a C.sub.1 -C.sub.4 -alkyl radical, or the two radicals are a C.sub.2 -C.sub.6 -alkylene radical which links the two oxygen atoms to form a cyclic acetal and is optionally branched or may carry one or two carboxyl groups, cyclohexyl or phenyl radicals.
  • 6. A substituted 5-oxotetrahydropyran of the formula IV as claimed in claim 5, where the substituents have the following meanings:
  • R.sup.2 CH.sub.3, 4,8,12-trimethyltridecyl or 4,8,12-trimethyl-3,7,11-tridecatrienyl and
  • X CN, COOH, COOCH.sub.3, COO--CH.sub.2 --CH.sub.2 --OH, COO--CH.sub.2 --CH.sub.2 --Cl, COO--CH.sub.2 --CH.sub.2 --N(CH.sub.3).sub.2, CHO, CH.sub.2 OH, CH.sub.2 OCH.sub.3 or CH(OCH.sub.3).sub.2 or one of the following structural elements X.sub.1 -X.sub.7. ##STR273##
  • 7. A process for preparing substituted 5-oxotetrahydropyrans of the formula IV as claimed in claim 6, which comprises reacting substituted acroleins of the general formula I, where
  • R.sup.1 is a C.sub.1 -C.sub.4 -alkyl, C.sub.6 -C.sub.18 -aryl, C.sub.7 -C.sub.18 -aralkyl, C.sub.1 -C.sub.4 -acyl, a halogenated C.sub.1 -C.sub.4 -acyl radical or another acid-labile protective group for the hydroxyl group,
  • with acrylonitriles, acrylates, acroleins, acrolein acetals, allyl alcohols or allyl ethers of the general formula II ##STR274## to give the corresponding 3,4-dihydro-2H-pyrans of the general formula III ##STR275## and, in a second step, converting the latter with an acid into the 5-oxotetrahydropyrans of the formula IV.
  • 8. A substituted chromen-6-one derivative of the formula VI, ##STR276## where X is the group --CN, --COOR.sup.3, --CHO, --CH.sub.2 OR.sup.7 or --CH(OR.sup.8).sub.2,
  • R.sup.2 is a C.sub.1 -C.sub.23 -alkyl, C.sub.2 -C.sub.23 -alkenyl, C.sub.6 -C.sub.18 -aryl or C.sub.7 -C.sub.18 -aralkyl radical,
  • R.sup.3 is hydrogen, a C.sub.1 -C.sub.4 -alkyl radical, a C.sub.1 -C.sub.4 -haloalkyl radical, a C.sub.1 -C.sub.4 -hydroxyalkyl radical or a C.sub.1 -C.sub.4 -aminoalkyl radical,
  • R.sup.4, R.sup.5, R.sup.6, independently of one another, are hydrogen or a C.sub.1 -C.sub.4 -alkyl radical,
  • R.sup.7 is hydrogen or a C.sub.1 -C.sub.4 -alkyl radical,
  • R.sup.8 is a C.sub.1 -C.sub.4 -alkyl radical, or the two radicals are a C.sub.2 -C.sub.6 -alkylene radical which links the two oxygen atoms to form a cyclic acetal and is optionally branched or may carry one or two carboxyl groups, cyclohexyl or phenyl radicals.
  • 9. A substituted chromen-6-one derivative of the formula VI as claimed in claim 8, where the substituents have the following meanings:
  • R.sup.2 CH.sub.3, 4,8,12-trimethyltridecyl or 4,8,12-trimethyl-3,7,11-tridecatrienyl,
  • R.sup.4, R.sup.5 and R.sup.6 independently of one another hydrogen or CH.sub.3 and
  • X CN, COOH, COOCH.sub.3, COO--CH.sub.2 --CH.sub.2 --OH, COO--CH.sub.2 --CH.sub.2 --Cl, COO--CH.sub.2 --CH.sub.2 --N(CH.sub.3).sub.2, CHO, CH.sub.2 OH, CH.sub.2 OCH.sub.3 or CH(OCH.sub.3).sub.2 or one of the following structural elements X.sub.1 -X.sub.7. ##STR277##10.
  • 10. A process for preparing substituted chromen-6-one derivatives of the general formula VI as claimed in claim 8, which comprises reacting substituted 5-oxotetrahydropyrans of the general formula IV with substituted vinyl ketones of the general formula V ##STR278##
  • 11. A process as claimed in claim 10, wherein the substituted 5-oxotetrahydropyrans of the general formula IV are reacted with secondary amines of the formula VIII
  • HN(R.sup.9).sub.2 VIII
  • where
  • R.sup.9 is a C.sub.1 -C.sub.4 -alkyl or phenyl radical, or the two R.sup.9 radicals represent a C.sub.2 -C.sub.6 -alkylene or C.sub.2 -C.sub.6 -alkoxyalkylene radical bridge to form a cyclic amine,
  • to give the corresponding enamines of the formula IX, ##STR279## the enamines of the formula IX are reacted with the substituted vinyl ketones of the general formula V ##STR280## to give the corresponding keto enamines of the formula X ##STR281## the keto enamines of the formula X are converted by addition of an acid into the corresponding diketone compounds of the formula XI ##STR282## and the diketones of the formula XI are converted by addition of a base into the substituted chromen-6-one derivatives of the general formula VI.
Priority Claims (1)
Number Date Country Kind
198 59 251 Dec 1998 DEX
US Referenced Citations (3)
Number Name Date Kind
2411969 Karrer et al. Dec 1946
2514168 Smith et al. Jul 1950
3947473 Scott et al. Mar 1976
Foreign Referenced Citations (2)
Number Date Country
2364141 Jun 1974 DEX
WO9811197 Mar 1998 WOX
Non-Patent Literature Citations (12)
Entry
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