Claims
- 1. A process for making a body absorbable polymeric material having a plurality of units of the general formula: ##STR3## in which R.sup.1 is hydrogen or methyl;
- R.sup.3 and R.sup.5 are identical or different and are groups selected from the class consisting of linear and branched alkylene, alkylene having 1 or 2 nonadjacent catenary oxygen or sulfur atoms, alkenylene, cycloalkylene and arylene; said groups having up to 25 carbon atoms in the cyclic compounds and from 2 to 25 carbon atoms in the non-cyclic compounds;
- R.sup.2 and R.sup.4 are hydrogen or alkyl having 1 to 4 carbon atoms or R.sup.2 and R.sup.4 together are linear or branched alkylene having one to four carbons forming with N--R.sup.3 --N a heterocyclic group having 5 or 6 ring atoms; and
- a and b are independently zero or one
- said process comprising the steps of: reacting at least one diamine with lactic or glycolic acid to form at least one diamidediol; and reacting said at least one diamidediol with a bischloroformate or a compound selected from the group consisting of dicarboxylic acids, methyl and ethyl esters of dicarboxylic acids, diacidchlorides, and anhydrides of a dicarboxylic acid to provide said body adsorbable polymeric material.
- 2. The process of claim 1 wherein said diamidediol is placed in a solvent prior to reacting with said compound or said bischloroformate.
- 3. The process of claim 1 wherein said compound is succinyl chloride.
- 4. The process of claim 2 wherein said solvent is selected from the group consisting of chlorobenzene, 1,1,2-trichloroethane and 1,4-dioxane.
- 5. The process of claim 2 which includes the additional step of removing said solvent after reacting with said compound or said bischloroformate.
- 6. The process of claim 1 wherein said diamidediol is a mixture comprised of 1,12-di(hydroxyacetamido)-4,9-dioxadodecane and 1,12-di(hydroxyacetamide)dodecane.
Parent Case Info
This is a division of application Ser. No. 103,915 filed Dec. 17, 1979, now U.S. Pat. No. 4,343,931.
US Referenced Citations (17)
Foreign Referenced Citations (1)
Number |
Date |
Country |
2236949 |
Jul 1972 |
DEX |
Non-Patent Literature Citations (1)
Entry |
Encyclopedia of Polymer Science and Technology, vol. 10, (1969), pp. 347-349, 483-491. |
Divisions (1)
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Number |
Date |
Country |
Parent |
103915 |
Dec 1979 |
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