Claims
- 1. A method for producing a substituted 1-butene oxide derivative of the formula [XII] ##STR33## wherein R.sup.4 is an amino-protecting group, and R.sup.5 is a hydrogen atom, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted aryl or an optionally substituted aralkyl, or an enantiomer thereof, comprising treating a 3-substituted aminobutane derivative of the formula [XI] ##STR34## wherein R.sup.4 and R.sup.5 are as defined above, R.sup.6 is a hydroxy-protecting group and Z is a substituent which functions as a leaving group with an oxygen atom, or an enantiomer thereof, in the presence of a base, and simultaneously conducting epoxidation and deprotection of primary hydroxy.
- 2. A method for producing a substituted 1-butene oxide derivative of the formula [XII] ##STR35## wherein R.sup.4 is an amino-protecting group and R.sup.5 is a hydrogen atom, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted aryl or an optionally substituted aralkyl, or an enantiomer thereof, comprising protecting a primary hydroxy of a 3-substituted aminobutane-1,2-diol derivative of the formula [X] ##STR36## wherein R.sup.4 and R.sup.5 are as defined above, or an enantiomer thereof, converting, with or without isolating the obtained compound, a secondary hydroxy to a leaving group to give a 3-substituted aminobutane derivative of the formula [XI] ##STR37## wherein R.sup.4 and R.sup.5 are as defined above, R.sup.6 is a hydroxy-protecting group and Z is a substituent which functions as a leaving group with an oxygen atom, or an enantiomer thereof, and treating the obtained compound in the presence of a base to simultaneously conduct epoxidation and deprotection of the primary hydroxy.
Priority Claims (1)
Number |
Date |
Country |
Kind |
7-248184 |
Sep 1995 |
JPX |
|
Parent Case Info
This application is a national stage of International Application No. PCT/JP96/02757, filed Sep. 24, 1996.
PCT Information
Filing Document |
Filing Date |
Country |
Kind |
102e Date |
371c Date |
PCT/JP96/02757 |
9/24/1996 |
|
|
5/19/1998 |
5/19/1998 |
Publishing Document |
Publishing Date |
Country |
Kind |
WO97/11938 |
4/3/1997 |
|
|
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
5733906 |
Jungheim et al. |
Mar 1998 |
|
Foreign Referenced Citations (3)
Number |
Date |
Country |
56-127373 |
Oct 1981 |
JPX |
6-271534 |
Sep 1994 |
JPX |
9509843 |
Apr 1995 |
WOX |
Non-Patent Literature Citations (1)
Entry |
Tetrahedron, vol. 51, No. 20, May 1995, pp. 5877-5890. |