Claims
- 1. A process for the preparation of LL-D45042 which comprises cultivating Streptomyces hygroscopicus LL-D45042 or a mutant thereof under aerobic conditions, in a sterile liquid medium containing assimilable sources of carbon, nitrogen and inorganic anion and cation salts, until LL-D45042 is formed and recovering and isolating LL-D45042.
- 2. A biologically pure culture Streptomyces hygroscopicus LL-D45042 or a LL-D45042 producing mutant thereof.
- 3. A biologically pure culture of the microorganism Streptomyces hygroscopicus, LL-D45042 or a mutant thereof, having the ability to produce a compound having the structure
- 4. A method of treating a mammal affected by cancer, which method comprises administering to said mammal an effective amount of a compound having the structure.
- 5. A pharmaceutical composition comprising an effective amount of a compound having the structure
- 6. An anticancer agent LL-D45042 produced by the process which comprises aerobically cultivating the organism Streptomyces hygroscopicus LL-D45042 or a mutant thereof in a sterile liquid medium containing assimilable sources of carbon, nitrogen and inorganic anion and cation salts until LL-D45042 is formed and recovering and isolating LL-D45042.
Parent Case Info
[0001] “This application claims priority from copending provisional Application No. 60/469,719 filed May 12, 2003 the entire disclosure of which is hereby incorporated by reference”.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60469719 |
May 2003 |
US |