Claims
- 1. A process for producing a butyric acid ester derivative of the following general formula (2) ##STR8## wherein R represents a straight-chain or branched-chain alkyl group containing 1 to 4 carbon atoms which comprises treating a mixture containing a compound of the following general formula (1)
- HOCH.sub.2 --CH.dbd.CH--COOR (1)
- wherein R has the same meaning as defined above, as an impurity and said butyric acid ester derivative of the general formula (2) as a major component
- with an addition reagent capable of adding itself to an ethylenic bond to convert said compound of the general formula (1) to an addition product separable from said butyric acid ester derivative of the general formula (2).
- 2. The process for producing a butyric acid ester derivative according to claim 1 wherein R is ethyl or t-butyl.
- 3. The process for producing a butyric acid ester derivative according to claim 2 wherein R is ethyl.
- 4. The process for producing a butyric acid ester derivative according to claim 1, wherein the addition product is a water-soluble compound.
- 5. The process for producing a butyric acid ester derivative according to claim 1, wherein the addition reagent is a salt of sulfurous acid.
- 6. The process for producing a butyric acid ester derivative according to claim 5 wherein the addition reagent is sodium sulfite or potassium sulfite.
- 7. The process for producing a butyric acid ester derivative according to claim 1, wherein the butyric acid ester derivative of the general formula (2) is an optically active compound.
- 8. A process for producing a butyric acid ester derivative of the general formula (2) ##STR9## wherein R represents a straight-chain or branched-chain alkyl group containing 1 to 4 carbon atoms, which comprises reacting a compound of the general formula (3) ##STR10## wherein R has the same meaning as defined above; X represents a group selected from the group consisting of chlorine atom, bromine atom, iodine atom, methanesulfonyloxy group, and substituted or unsubstituted phenylsulfonyloxy group, with a salt of prussic acid in the presence of an addition reagent capable of adding itself to an ethylenic bond to convert a compound of the general formula (1)
- HOCH.sub.2 --CH.dbd.CH--COOR (1)
- wherein R has the same meaning as defined above, to an addition product separable from said butyric acid ester derivative of the general formula (2).
- 9. The process for producing a butyric acid ester derivative according to claim 8 wherein R is ethyl or t-butyl.
- 10. The process for producing a butyric acid ester derivative according to claim 9 wherein R is ethyl.
- 11. The process for producing a butyric acid ester derivative according to claim 8, wherein the addition product is a water-soluble compound.
- 12. The process for producing a butyric acid ester derivative according to claim 8, wherein the addition reagent is a salt of sulfurous acid.
- 13. The process for producing a butyric acid ester derivative according to claim 12 wherein the addition reagent is sodium sulfite or potassium sulfite.
- 14. The process for producing a butyric acid ester derivative according to claim 8, wherein X is chlorine atom or bromine atom.
- 15. The process for producing a butyric acid ester derivative according to claim 14 wherein X is chlorine atom.
- 16. The process for producing a butyric acid ester derivative according to claim 8, wherein the salt of prussic acid is sodium cyanide or potassium cyanide.
- 17. The process for producing a butyric acid ester derivative according to claim 16 wherein the salt of prussic acid is sodium cyanide.
- 18. The process for producing a butyric acid ester derivative according to claim 8, wherein each of the compounds of the general formula (3) and the butyric acid ester derivative of the general formula (2) is an optically active compound.
- 19. A process for producing a butyric acid ester derivative of the general formula (2) ##STR11## wherein R represents a straight-chain or branched-chain alkyl group containing 1 to 4 carbon atoms, which comprises reacting a compound of the general formula (3) ##STR12## wherein R has the same meaning as defined above; X represents a group selected from the group consisting of chlorine atom, bromine atom, iodine atom, methanesulfonyloxy group, and substituted or unsubstituted phenylsulfonyloxy group, with a salt of prussic acid
- wherein the reaction is carried out by a flow method.
- 20. The process for producing a butyric acid ester derivative according to claim 19 wherein the reaction is carried out by the flow method using a reactor selected from the group consisting of a tubular reactor, a thin-film reactor and a series of continuous stirred tank reactors.
- 21. The process for producing a butyric acid ester derivative according to claim 20 wherein the tubular reactor is used as the reactor.
- 22. The process for producing a butyric acid ester derivative according to claim 20 wherein the thin-film reactor is used as the reactor.
- 23. The process for producing a butyric acid ester derivative according to claim 19, wherein R is ethyl or t-butyl.
- 24. The process for producing a butyric acid ester derivative according to claim 23 wherein R is ethyl.
- 25. The process for producing a butyric acid ester derivative according to claim 19, wherein X is chlorine atom or bromine atom.
- 26. The process for producing a butyric acid ester derivative according to claim 25 wherein X is chlorine atom.
- 27. The process for producing a butyric acid ester derivative according to claim 19, wherein the salt of prussic acid is sodium cyanide or potassium cyanide.
- 28. The process for producing a butyric acid ester derivative according to claim 27 wherein the salt of prussic acid is sodium cyanide.
- 29. The process for producing a butyric acid ester derivative according to claim 19, wherein each of the compound of the general formula (3) and the butyric acid ester derivative of the general formula (2) is an optically active compound.
- 30. The process for producing a butyric acid ester derivative according to claim 19, wherein the reaction is carried out in the presence of an addition reagent capable of adding itself to an ethylenic bond to convert a compound of the general formula (1)
- HOCH.sub.2 --CH.dbd.CH--COOR (1)
- wherein R has the same meaning as defined above, to an addition product separable from the butyric acid ester derivative of the general formula (2) ##STR13## wherein R has the same meaning as defined above.
- 31. The process for producing a butyric acid ester derivative according to claim 30 wherein the addition product is a water-soluble compound.
- 32. The process for producing a butyric acid ester derivative according to claim 30 wherein the addition reagent is a salt of sulfurous acid.
- 33. The process for producing a butyric acid ester derivative according to claim 32 wherein the addition reagent is sodium sulfite or potassium sulfite.
Priority Claims (1)
Number |
Date |
Country |
Kind |
9-362821 |
Dec 1997 |
JPX |
|
Parent Case Info
This application is a 371 of PCT/JP98/03686 filed Aug. 20, 1998.
PCT Information
Filing Document |
Filing Date |
Country |
Kind |
102e Date |
371c Date |
PCT/JP98/03686 |
8/20/1998 |
|
|
9/7/1999 |
9/7/1999 |
Publishing Document |
Publishing Date |
Country |
Kind |
WO99/31050 |
6/24/1999 |
|
|
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
5430171 |
Mitsuhashi et al. |
Jul 1995 |
|
5908953 |
Matsuda et al. |
Jun 1999 |
|