Claims
- 1. A process for producing a compound represented by formula (II): ##STR22## wherein X is a halogen atom, each of A.sup.1, A.sup.2 and A.sup.3 are the same or different, and are selected from a carbon atom or a nitrogen atom, provided that at least one of A.sup.1, A.sup.2 and A.sup.3 is a nitrogen atom, each of R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are the same or different, and are selected from the group consisting of a hydrogen atom, a lower alkyl group, a cyano group, a carboxyl group, a lower alkoxycarbonyl group, a halogen atom, and a nitro group, provided that where R.sup.1 and R.sup.2 are adjacent to each other, R.sup.1 and R.sup.2 may be combined with each other to form a 5- or 6-membered ring which may carry on the ring thereof one substituent selected from the group consisting of a lower alkyl group, a nitrile group, a carboxyl group, a lower alkoxycarbonyl group, a carbamoyl group, a halogen atom, and a nitro group which comprises reacting a compound represented by the formula (I): ##STR23## wherein each of R.sup.10, R.sup.20, R.sup.30 and R.sup.40 may be the same or different, and are selected from a hydrogen atom, a lower alkyl group, a cyano group, a carboxyl group, a lower alkoxycarbonyl group, a carbamoyl group, a halogen atom, a nitro group, provided that in cases where R.sup.10 and R.sup.20 are adjacent to each other, R.sup.10 and R.sup.20 may be combined with each other to form a 5- or 6-membered ring which may carry on the ring thereof one substituent selected from the group consisting of a lower alkyl group, a nitrile group, a carboxyl group, a lower alkoxycarbonyl group, a carbamoyl group, a halogen atom, a nitro group and A.sup.1, A.sup.2 and A.sup.3 are as defined above, with a quaternary ammonium halide in the presence of phosphorus pentoxide.
- 2. The process according to claim 1, wherein each of A.sup.1 and A.sup.2 is a carbon atom, A.sup.3 is a nitrogen atom, R.sup.4 is hydrogen atom or a lower alkyl group, and each of R.sup.2, R.sup.3 and R.sup.4 are the same or different, and are selected from a hydrogen atom, a lower alkyl group, a nitrile group or a carboxyl group.
- 3. The process according to claim 1, wherein A.sup.1 is a carbon atom or a nitrogen atom, A.sup.2 is a carbon atom, A.sup.3 is a nitrogen atom, R.sup.1 and R.sup.2 are combined with each other and form a 6-membered ring which may carry on the ring thereof one substituent selected from the group consisting of a lower alkyl group, a nitrile group and a carboxyl group, and each of R.sup.3 and R.sup.4 is a hydrogen atom, a lower alkyl group, a nitrile group or a carboxyl group.
- 4. The process according to claim 1, wherein the compound represented by the formula (I) ##STR24## is a quinoline derivative or a quinoxaline derivative wherein R.sup.10 and R.sup.20 are combined with each other to form an aromatic 6-membered ring together with the ring of ##STR25## wherein A.sup.1, A.sup.2 and A.sup.3 are as defined in claim 1.
Priority Claims (1)
Number |
Date |
Country |
Kind |
8-346666 |
Dec 1996 |
JPX |
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Parent Case Info
This application is a 371 of PCT/JP97/04508.
PCT Information
Filing Document |
Filing Date |
Country |
Kind |
102e Date |
371c Date |
PCT/JP97/04508 |
12/9/1997 |
|
|
6/8/1999 |
6/8/1999 |
Publishing Document |
Publishing Date |
Country |
Kind |
WO98/25906 |
6/18/1998 |
|
|
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
4404388 |
h et al. |
Sep 1983 |
|
4739057 |
Leoney-Bay |
Apr 1988 |
|
Foreign Referenced Citations (3)
Number |
Date |
Country |
072777 |
Aug 1982 |
EPX |
0 155 911 |
Sep 1985 |
EPX |
0251246 |
Jun 1987 |
EPX |
Non-Patent Literature Citations (2)
Entry |
Paquette In Encyclopedia of Reagents for Organic Synthesis. Vol. 6, p. 4127-4129, 1995. |
Journal of Heterocyclic Chemistry: J.B. Paine, "A Conversion of Nicotinate Esters from 3-Cyanopyridones". Vol. 24, No. 2, p. 351 (references cited in the description. particularly p. 351). |