Claims
- 1. A process to produce a compound of the formula ##STR95## wherein A is ##STR96## R.sub.1 is selected from the group consisting of hydrogen, lower alkyl, phenyl, alkoxy lower alkyl, pyridyl, and tolyl; R is hydrogen or lower alkyl; R.sub.3 is selected from the group consisting of hydrogen and lower alkyl; R.sub.4 is selected from the group consisting of hydrogen, halogen, nitro, cyano, trifluoromethyl, lower alkyl, hydroxy lower alkyl and lower alkanoyl; R.sub.6 is selected from the group consisting of phenyl, mono-halo or mono-nitro substituted phenyl, di-halo or halo-nitro substituted phenyl, pyridyl and mono-halo or mono-nitro substituted pyridyl; and ##STR97## is selected from the group consisting of ##STR98## which comprises the stepwise reaction of a compound of the formula ##STR99## wherein A, R.sub.3, R.sub.4 and ##STR100## are as above (a) with the anion generated from acylamino malonic ester, i.e., a compound of the formula ##STR101## wherein R is lower alkyl and R.sub.1 is selected from the group consisting of hydrogen, lower alkyl, phenyl, alkoxy lower alkyl, pyridyl and tolyl;
- (b) decarboxylating the product of (a) with an alkali metal alkoxide;
- (c) dehydrating the product of (b) to produce the final product.
- 2. A process to produce a compound of the formula ##STR102## wherein R.sub.1 ' is selected from the group consisting of phenyl, and pyridyl; R is selected from the group consisting of lower alkoxy and NR'R" where R' and R" are lower alkyl; R.sub.3 is selected from the group consisting of hydrogen and lower alkyl; R.sub.6 is selected from the group consisting of phenyl, mono-halo or mono-nitro substituted phenyl, dihalo or halo-nitro substituted phenyl, pyridyl and mono-halo or mono-nitro substituted pyridyl; and R.sub.4 is selected from the group consisting of hydrogen, halogen, nitro, cyano, trifluoromethyl, lower alkyl, mono- or di-C.sub.1 to C.sub.7 alkyl or phenyl, chlorophenyl or tolyl substituted amino, and lower alkanoyl; which comprises reacting a compound of the formula ##STR103## wherein R.sub.3 is as above; R.sub.4 is as above; and R.sub.6 is as above with a compound of the formula ##STR104## wherein R.sub.1 ' is selected from the group consisting of phenyl, and pyridyl and R is selected from the group consisting of lower alkoxy and NR'R" where R' and R" are lower alkyl in the presence of a strong base at below room temperature and subsequently allowing the reaction mixture to warm to room temperature.
Parent Case Info
This is a division of application Ser. No. 905,820 filed May 15, 1978, now U.S. Pat. No. 4,280,957 which is a continuation of Ser. No. 663,660, filed Mar. 4, 1978 (now abandoned) which is a CIP of Ser. No. 602,691, filed Aug. 7, 1975 (now abandoned) which is a CIP of Ser. No. 504,924, filed Sept. 11, 1974 (now abandoned).
US Referenced Citations (7)
Non-Patent Literature Citations (1)
Entry |
Fryer, et al., J. Heterocyclic Chemistry, vol. 15, pp. 619-624 (6/78). |
Divisions (1)
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Number |
Date |
Country |
Parent |
905820 |
May 1978 |
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Continuations (1)
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Number |
Date |
Country |
Parent |
663660 |
Mar 1978 |
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Continuation in Parts (2)
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Number |
Date |
Country |
Parent |
602691 |
Aug 1975 |
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Parent |
504924 |
Sep 1974 |
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