Claims
- 1. A process for producing an optically active 1-substituted-1,3-propanediol represented by formula (III): ##STR9## wherein R.sup.2 represents a lower alkyl group, a benzyl group or a phenyl group which may have a substituent group, and * designates an asymmetric carbon atom, which comprises hydrogenating a 3-substituted-3-oxopropanol or 3-substituted-3-oxopropanal represented by formula (IV): ##STR10## wherein R.sup.2 is as defined above, and R.sup.3 represents --CHO or --CH.sub.2 OH in the presence of a ruthenium-phosphine complex represented by formula (I):
- [RuI(p-cymene) (R.sup.1 -BINAP)]I.sub.3 (I)
- wherein R.sup.1 -BINAP represents an optically active tertiary phosphine represented by formula (II): ##STR11## wherein R.sup.1 represents a phenyl group which may be substituted with a lower alkyl group or a halogen atom at the p-position and/or m-position.
Priority Claims (1)
Number |
Date |
Country |
Kind |
3-274008 |
Oct 1991 |
JPX |
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Parent Case Info
This is a continuation-in-part of application Ser. No. 07/964,904, filed Oct. 22, 1992, now U.S. Pat. No. 5,286,888.
US Referenced Citations (7)
Foreign Referenced Citations (1)
Number |
Date |
Country |
55-61937 |
Oct 1980 |
JPX |
Non-Patent Literature Citations (2)
Entry |
J. Chem. Soc., Chem. Commun., 1985, 922-924. |
J. Org. Chem., 1988, 53, 4081-4084. |
Continuation in Parts (1)
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Number |
Date |
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Parent |
964904 |
Oct 1992 |
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