Claims
- 1. A process for producing a compound of formula (3)
- 2. The process as defined in claim 1, wherein R1 and R2 or R2 and R3 together form a methylenedioxy group.
- 3. The process as defined in claim 1, wherein R2 is a hydroxyl group, R3 is a methoxy group, and R1, R4 and R5 are hydrogen atoms.
- 4. The process of claim 3, wherein in formulas (1) and (2) R2 is a benzyloxy group.
- 5. The process as defined in claim 1, wherein R2 is a methyl group, R3 is a hydroxyl group, and R1, R4 and R5 are hydrogen atoms.
- 6. The process as defined in claim 1, wherein in formulas (1) and (2) R3 is a benzyloxy group.
- 7. The process as defined in claim 1, wherein R2 and R3 together form a methylenedioxy group, and R1, R4 and R5 are hydrogen atoms.
- 8. The process as defined in claim 1, wherein R1 is a hydroxyl group, R3 is a methoxy group, and R2, R4 and R5 are hydrogen atoms.
- 9. The process as defined in claim 8, wherein in formulas (1) and (2) R1 is a benzyloxy group.
- 10. The process as defined in claim 1, wherein R3 is a hydroxyl group, and R1, R2, R4 and R5 are hydrogen atoms.
- 11. The process as defined in claim 10, wherein in formulas (1) and (2) R3 is a benzyloxy group.
- 12. The process as defined in claim 1, wherein R2 is a hydroxyl group, R3 is a methyl group, and R1, R4 and R5 are hydrogen atoms.
- 13. The process as defined in claim 1, wherein in formulas (1) and (2) R2 is a benzyloxy group.
- 14. The process as defined in claim 1, wherein R1 and R3 are a hydroxyl group, and R2, R4 and R5 are hydrogen atoms.
- 15. The process as defined in claim 14, wherein in formulas (1) and (2) R1 and R3 are benzyloxy groups.
- 16. The process as defined in claim 14, wherein in formulas (1) and (2) R1 and R3 is a benzyloxy group.
- 17. The process as defined in claim 1, wherein said catalyst is at least one of palladium carbon or platinum carbon.
- 18. The process as defined in claim 1, wherein said reductive alkylating is performed in a solvent, which is methanol or water and methanol mixture.
- 19. A process for producing a compound of formula (2), which comprises converting a carboxyl group in a compound of formula (4) into a formyl group
- 20. The process as defined in claim 19, wherein R1 and R2, or R2 and R3 form a methylenedioxy group.
- 21. The process as defined in claim 19, wherein R2 is a hydroxyl group, R3 is a methoxy group, and R1, R4 and R5 are a hydrogen atom
- 22. A process for producing a compound of formula (1), which comprises selectively reducing a carbon-carbon double bond in a compound of the formula (2),
- 23. The process as defined in claim 22, wherein R1 and R2, or R2 and R3 form a methylenedioxy group.
- 24. The process as defined in claim 22, wherein R2 is a hydroxyl group, R3 is a methoxy group, and R1, R4 and R5 are hydrogen atoms
- 25. The process as defined in claim 22, wherein said selectively reducing is conducted in the presence of a hydrogenation catalyst.
- 26. The process as defined in claim 22, wherein said selectively reducing is conducted in the presence of at least one of a palladium catalyst, platinum catalyst, and rhodium catalyst.
- 27. A process for producing a compound of formula (1), which comprises:
- 28. The process as defined in claim 27, wherein R1 and R2, or R2 and R3 form a methylenedioxy group.
- 29. The process as defined in claim 28, wherein R2 is a hydroxyl group, R3 is a methoxy group, and R1, R4 and R5 are hydrogen atoms.
- 30. A process for producing a compound of formula (3)
- 31. The process as defined in claim 30, wherein R1 and R2, or R2 and R3 may be form a methylenedioxy group.
- 32. The process as defined in claim 30, wherein R2 is a hydroxyl group, R3 is a methoxy group, and R1, R4 and R5 are hydrogen atoms.
- 33. The process as defined in claim 30, wherein said catalyst is at least one of palladium carbon or platinum carbon.
- 34. The process as defined in claim 30, wherein said reductive alkylating is performed in a solvent, which is methanol or water and methanol mixture.
- 35. A process for producing compound of formula (3)
- 36. The process as defined in claim 35, wherein R1 and R2 or R2 and R3 form a methylenedioxy group.
- 37. The process as defined in claim 35, wherein R2 is a hydroxyl group, R3 is a methoxy group, and R1, R4 and R5 are hydrogen atoms.
- 38. The process as defined in claim 35, wherein said catalyst is at least one of palladium carbon or platinum carbon.
- 39. The process as defined in claim 35, wherein said reductive alkylating is performed in a solvent, which is methanol or water and methanol mixture
- 40. A process for producing a 3-(3-hydroxy-4-methoxyphenyl) propionaldehyde, which comprises: selectively reducing a carbon-carbon double bond of 3-hydoroxy-4-methoxycinnamaldehyde; or converting a carboxyl group of 3-(3-hydoroxy-4-methoxyphenyl)propionic acid into a formyl group.
- 41. The process as defined in claim 40, which comprises converting a carboxyl group of 3-(3-hydoroxy-4-methoxyphenyl)propionic into a formyl group.
- 42. The process as defined in claim 40, which comprises selectively reducing a carbon-carbon double bond of 3-hydoroxy-4-methoxycinnamaldehyde.
- 43. The process as defined in claim 40, wherein said selectively reducing is conducted in the presence of a hydrogenation catalyst.
- 44. The process as defined in claim 43, wherein said catalyst is at least one of palladium catalyst, platinum catalyst, and rhodium catalyst.
- 45. The process as defined in claim 41, wherein said 3-(3-hydoroxy-4-methoxyphenyl)propionic acid is obtained by selectively reducing a carbon-carbon double bond of 3-hydoroxy-4-methoxycinnamic acid.
- 46. The process as defined in claim 45, wherein said selectively reducing is conducted in the presence of a hydrogenation catalyst.
- 47. The process as defined in claim 46, wherein said catalyst is at least one of palladium catalyst, platinum catalyst, and rhodium catalyst.
- 48. A process for producing a N-[N-[3-(3-hydroxy-4-methoxyphenyl) propyl]-L-α-aspartyl]-L-phenylalanine 1-methyl ester, which comprises reductively alkylating 3-(3-hydroxy-4-methoxyphenyl) propionaldehyde with an aspartame.
- 49. 3-(3-hydroxy-4-methoxyphenyl) propionaldehyde.
Priority Claims (2)
Number |
Date |
Country |
Kind |
11-287398 |
Oct 1999 |
JP |
|
11-371284 |
Dec 1999 |
JP |
|
CROSS-REFERENCE TO A RELATED APPLICATION
[0001] The present application is a continuation application of PCT/JP00/06626 filed Sep. 26, 2000, the entire contents of which is incorporated by reference.
Continuations (1)
|
Number |
Date |
Country |
Parent |
PCT/JP00/06626 |
Sep 2000 |
US |
Child |
10117196 |
Apr 2002 |
US |