Claims
- 1. A composition comprising an alkylated and crosslinked polymer and salts thereof comprising the reaction product of:(a) one or more polymers, or salts and copolymers thereof having a repeat unit with the formula: where n is a positive integer and each R, independently, is H or a C1-C8 alkyl group;(b) at least one aliphatic alkylating agent; and (c) a crosslinking agent, wherein said reaction product has: (i) at least some of the nitrogen atoms in said repeat units unreacted with said alkylating agent; and (ii) less than 10 mol % of the nitrogen atoms in said repeat units that react with said alkylating agent form quaternary ammonium units.
- 2. The composition of claim 1 wherein the salt has at least one counterion selected from the group consisting of: Cl−, Br−, CHOSO3−, HSO4−, SO42−, HCO3−, CO32−.
- 3. The composition of claim 1 wherein said polymer is crosslinked by means of a multifunctional crosslinking agent, said agent being present in an amount from about 0.5-25% by weight, based upon the combined weight of monomer and crosslinking agent.
- 4. The composition of claim 1 wherein the crosslinking agent comprises epichlorohydrin.
- 5. The composition of claim 1 wherein said alkylating agent has the formula RX where R is a C1-C20 alkyl, C1-C20 hydroxyalkyl, C1-C20 alkylammonium, or C1-C20 alkylamido group and X is one or more electrophilic leaving groups.
- 6. The composition of claim 5 wherein said alkylating agent comprises a C1-C20 alkyl halide.
- 7. The composition of claim 5 wherein said alkylating agent comprises a C1-C20 alkyl halide ammonium salt.
- 8. The composition of claim 7 wherein said alkyl halide ammonium salt is a C4-C12 haloalkyl trimethylammonium salt.
- 9. The composition of claim 1 wherein said polymer is reacted with at least two of said alkylating agent, one of said alkylating agents has the formula RX where R is a C1-C20 alkyl group and X is one or more electrophilic leaving groups, and the other of said alkylating agents has the formula R′X where R′ is a C1-C20 alkyl ammonium group and X is one or more electrophilic leaving groups.
- 10. The composition of claim 9 wherein one of said alkylating agents having the formula RX is an alkyl halide and the other of said alkylating agents having the formula R′X is an alkyl halide ammonium salt.
- 11. The composition of claim 10 wherein said alkyl halide is a C4-C20 alkyl halide and said alkyl halide ammonium salt is a C4-C18 alkyl halide ammonium salt.
- 12. The composition of claim 11 wherein said alkyl halide is a C10 alkyl halide and said alkyl halide ammonium salt is a C6 alkyl halide trimethyl ammonium salt.
- 13. The composition of claim 1, further comprising a pharmaceutically acceptable carrier.
RELATED APPLICATIONS
This application is a continuation of U.S. Ser. No. 10/060,556 filed Jan. 30, 2002, now abandoned which is a continuation of U.S. Ser. No. 09/803,647 filed Mar. 9, 2001, now U.S. Pat. No. 6,433,026, which is a continuation of U.S. Ser. No. 09/532,984 filed Mar. 22, 2000, now U.S. Pat. No. 6,225,355 which is a continuation of U.S. Ser. No. 09/388,876 filed Sep. 2, 1999, now U.S. Pat. No. 6,066,678, which is a continuation of U.S. Ser. No. 09/288,357 filed Apr. 8, 1999, now U.S. Pat. No. 5,981,693, which is a continuation of U.S. Ser. No. 09/129,286 filed Aug. 5, 1998, now U.S. Pat. No. 5,917,007, which is a continuation of U.S. Ser. No. 08/910,692 filed Aug. 13, 1997, now abandoned, which is a divisional of U.S. Ser. No. 08/460,980 filed on Jun. 5, 1995, now U.S. Pat. No. 5,679,717, which is a continuation-in-part of U.S. Ser. No. 08/258,431 filed Jun. 10, 1994, now abandoned, the entire teachings of all of which are incorporated herein by reference.
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Continuations (7)
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10/060556 |
Jan 2002 |
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Child |
10/264350 |
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Parent |
09/803647 |
Mar 2001 |
US |
Child |
10/060556 |
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US |
Parent |
09/532984 |
Mar 2000 |
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09/803647 |
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US |
Parent |
09/388876 |
Sep 1999 |
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09/532984 |
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US |
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09/288357 |
Apr 1999 |
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09/388876 |
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09/129286 |
Aug 1998 |
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09/288357 |
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US |
Parent |
08/910692 |
Aug 1997 |
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09/129286 |
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Continuation in Parts (1)
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08/258431 |
Jun 1994 |
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08/460980 |
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US |