Claims
- 1. A process for producing compound E by reacting compounds C and D: comprising the steps of:a) dissolving compounds C and D together in DMF; b) adding to said solution of C and D: i) a water scavenger; ii) a metal hydroxide selected from LiOH, NaOH or KOH; and iii) a phase transfer catalyst c) allowing the mixture produced in step b) to react at room temperature for 2 to 48 hours; d) adding an organic solvent and water to said mixture to create an aqueous phase and an organic phase; and e) purifying compound E from said organic phase; wherein:R2 is selected from hydrogen, C1-C6 straight or branched alkyl, C2-C6 straight or branched alkenyl or alkynyl or Ar, wherein said alkyl, alkenyl or alkynyl is optionally substituted with Ar; n is 0 or 1; “Hal” is any halogen; and each R′ is an independently selected carboxyl protecting group.
- 2. The process according to claim 1, wherein said water scavenger is sodium sulfate.
- 3. The process according to claim 1, wherein said metal hydroxide is LiOH.
- 4. The process according to claim 1, wherein said phase transfer catalyst is Bu4NI.
- 5. The process according to claim 1, wherein n is 1.
- 6. The process according to claim 1, wherein each Hal is Br.
- 7. The process according to claim 1, wherein R2 is t-butyl.
- 8. The process according to claim 1, wherein R′ is benzyl.
CROSS-REFERENCE TO PRIOR APPLICATION
This application is a continuation-in-part of copending U.S. patent application Ser. No. 09/136,339, filed Aug. 19, 1998.
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Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
09/136339 |
Aug 1998 |
US |
Child |
09/235894 |
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US |