Claims
- 1. A method of separating enantiomeric lactam esters comprising contacting the lactam esters with a biocatalyst in an aqueous solution, an organic solvent, or a mixture of organic and aqueous solvents wherein only one enantiomer is selectively hydrolyzed to give the optically active isomer of the corresponding acid, and separating the hydrolysis product from the unreacted lactam esters.
- 2. The method of claim 1 wherein the biocatalyst is an enzyme or a microorganism.
- 3. The method of claim 1 wherein the biocatalyst is an enzyme.
- 4. The method of claim 1 wherein the biocatalyst is in an aqueous buffer solution.
- 5. The method of claim 1 wherein the lactam esters are racemic.
- 6. The method of claim 3 wherein the enzyme is derived from thermostable enzymes.
- 7. The method of claim 1 wherein the reaction temperatures for the enzymatic resolution is in the range of 0° C. and 50° C.
- 8. The method of claim 1 wherein the undesired isomer after the enzymatic resolution is racemized under basic conditions and recycled.
- 9. The method of claim 1 wherein the enzyme is recovered by precipitation with a salt and recycled for reuse.
- 10. The method of claim 1 wherein the lactam esters are of the formula (I):
- 11. The method of claim 10 wherein the lactams are of the formula (II):
- 12. The method of claim 11 wherein the lactams are of the formula (III):
- 13. The method of claim 12 wherein the lactams are of the formula (IV):
- 14. The method of claim 13 wherein the lactams are of the formula (V):
Parent Case Info
[0001] This application claims priority to U.S. Provisional Application No. 60/074,830 filed Feb. 17, 1998.
Continuations (1)
|
Number |
Date |
Country |
Parent |
09250197 |
Feb 1999 |
US |
Child |
09876199 |
Jun 2001 |
US |