Claims
- 1. A compound selected from the group consisting of a benzazole of the formula ##STR15## in which R.sub.2 is carboxy, lower alkoxycarbonyl, or hydroxymethyl;
- alk is lower alkylene;
- each of X.sub.1 and X.sub.2, independently of the other is oxygen or sulfur;
- Ph is 1,2-phenylene, or 1,2-phenylene which is mono- or disubstituted with lower alkyl, lower alkoxy, lower alkanoyl, trifluoromethyl, or halo;
- X.sub.3 is oxygen, sulfur, imino, or imino substituted with lower alkyl, di(lower alkyl)amino lower alkyl, phenyl or phenylalkyl; and
- R.sub.3 is lower alkyl, fluoro lower alkyl, or cycloalkyl of 3 to 8 carbon atoms; and
- the pharmaceutically acceptable salts thereof.
- 2. A compound according to claim 1 wherein said benzazole is of the formula: ##STR16## in which R.sub.2 is carboxy, lower alkoxycarbonyl, or hydroxymethyl;
- alk is alkylene of 1 to 4 carbon atoms;
- X.sub.2 is oxygen or sulfur;
- X.sub.3 is oxygen or sulfur;
- R.sub.5 is hydrogen, alkyl of up to 4 carbon atoms, alkoxy of up to 4 carbon atoms, or halogen of atomic number up to and including 35; and
- R.sub.3 is a straight chained or .alpha.-branched alkyl group of up to 4 carbon atoms.
- 3. A compound according to claim 2 wherein X.sub.2 is sulfur; R.sub.5 is hydrogen, methyl, methoxy, or chloro; and R.sub.3 is t-butyl or isopropyl.
- 4. A compound according to claim 3 wherein R.sub.2 is carboxy and alk is ethylene.
- 5. A compound as according to claim 2 which is N-[2-tert.-butyl-5-methoxy-benzthiazol-6-yl]-dithiocarbamic acid S-(2-carboxyethyl)-ester or a pharmaceutically acceptable salt thereof.
- 6. A compound as according to claim 2 which is N-[2-tert.-butyl-benzthiazol-6-yl]-dithiocarbamic acid S-(2-carboxyethyl)-ester or a pharmaceutically acceptable salt thereof.
- 7. A compound as according to claim 2 which is N-[2-tert.-butyl-5-chloro-benzthiazol-6-yl]-dithiocarbamic acid S-(2-carboxyethyl)-ester or a pharmaceutically acceptable salt thereof.
- 8. A compound as according to claim 2 which is N-[2-tert.-butyl-5-methyl-benzthiazol-6-yl]-dithiocarbamic acid S-(2-carboxyethyl)-ester or a pharmaceutically acceptable salt thereof.
- 9. A compound as according to claim 2 which is N-[2-tert.-butyl-5-methoxy-benzthiazol-6-yl]-dithiocarbamic acid S-(2-carboxypropyl)-ester or a pharmaceutically acceptable salt thereof.
- 10. A compound as according to claim 2 which is N-[2-tert.-butyl-5-methylthio-benzoxazol-6-yl]-dithiocarbamic acid S-carboxymethyl-ester or a pharmaceutically acceptable salt thereof.
- 11. A compound as according to claim 2 which is N-[tert.-butyl-5-methoxy-benzthiazol-6-yl]-thiocarbamic acid O-(2-carboxyethyl)-ester or a pharmaceutically acceptable salt thereof.
- 12. A compound according to claim 2 which is N-[2-tert.-butyl-5-methoxy-benzthiazol-6-yl]-thiocarbamic acid S-(2-carboxyethyl)-ester or a pharmaceutically acceptable salt thereof.
- 13. A compound according to claim 2 which is N-[2-tert.-butyl-5-methyl-benzoxazol-6-yl]-dithiocarbamic acid S-(2-carboxyethyl)-ester or a pharmaceutically acceptable salt thereof.
- 14. A compound according to claim 2 which is N-[2-tert.-butyl-5-chloro-benzoxazol-6-yl]-dithiocarbamic acid S-(2-carboxyethyl)-ester or a pharmaceutically acceptable salt thereof.
- 15. A compound according to claim 2 which is N-[2-tert.-butyl-5-methoxy-benzoxazol-6-yl]-dithiocarbamic acid S-(2-carboxyethyl)-ester or a pharmaceutically acceptable salt thereof.
- 16. A compound according to claim 2 which is N-[2-isopropylbenzimidazol-5-yl]-dithiocarbamic acid S-(2-carboxyethyl)-ester or a pharmaceutically acceptable salt thereof.
- 17. A compound according to claim 2 which is N-[2-isopropyl-5-methyl-benzoxazol-6-yl]-dithiocarbamic acid S-(2-carboxyethyl)-ester or a pharmaceutically acceptable salt thereof.
- 18. A compound according to claim 2 which is N-[2-tert.-butyl-benzoxazol-6-yl]-dithiocarbamic acid S-(2-carboxyethyl)-ester or a pharmaceutically acceptable salt thereof.
- 19. A compound according to claim 2 which is N-[2-isopropylbenzoxazol-6-yl]-dithiocarbamic acid S-(2-carboxyethyl)-ester or a pharmaceutically acceptable salt thereof.
- 20. A compound according to claim 2 which is N-[2-isopropylbenzthiazol-6-yl]-dithiocarbamic acid S-(2-carboxyethyl)-ester or a pharmaceutically acceptable salt thereof.
- 21. A compound according to claim 2 which is N-[2-isopropyl-5-methoxy-benzthiazol-6-yl]-dithiocarbamic acid S-(2-carboxyethyl]-ester or a pharmaceutically acceptable salt thereof.
- 22. A compound according to claim 2 which is N-[2-tert.-butyl-5,7-dimethyl-benzthiazol-6-yl]-dithiocarbamic acid S-(2-carboxyethyl)-ester or a pharmaceutically acceptable salt thereof.
- 23. A pharmaceutical composition preparation containing an anthelmintically effective amount of a compound according to claim 2 in admixture with customary pharmaceutical auxilliaries and/or carriers.
- 24. The method of combatting parasitic helminths in a warm-blooded animal which comprises administering thereto an effective amount of a compound according to claim 1.
CROSS REFERENCE TO RELATED APPLICATIONS
This is a divisional of Ser. No. 418,955 filed Sept. 16, 1982, now U.S. Pat. No. 4,511,567, which in turn is a continuation-in-part of Ser. No. 262,259 filed May 11, 1981, now abandoned.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
3646049 |
Hoff |
Feb 1972 |
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Divisions (1)
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Number |
Date |
Country |
Parent |
418955 |
Sep 1982 |
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Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
262259 |
May 1981 |
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