Claims
- 1. A process for the preparation of a 2-alkoxy-6-trifluoromethyl-N-([1,2,4]triazolo[1,5-c]pyrimidin-2-yl)benzenesulfonamide of Formula I whereinW represents H or O(C1-C3 alkyl); Z represents H or O(C1-C3 alkyl), with the proviso that at least one of W or Z represents O(C1-C3 alkyl); and R represents C1-C4 alkyl optionally substituted with at least 2 and up to the maximum possible number of fluorine atoms which comprises contacting a 2-fluoro-6-trifluoromethyl-N-([1,2,4]triazolo-[1,5-c]pyrimidin-2-yl)benzenesulfonamide of Formula II whereinW and Z are as previously defined with an alcohol ROH wherein R is as previously defmed and at least 2 molar equivalents of base in a polar aprotic organic solvent.
- 2. The process of claim 1 in which the polar aprotic organic solvent is an alkyl nitrile, an ether, a carboxylic ester, a carboxylic amide, a urea or mixtures thereof.
- 3. The process of claim 1 in which the process is conducted at a temperature from about −10 to about 40° C.
- 4. The process of claim 1 in which W and Z are both OCH3.
- 5. The process of claim 1 in which R is −CF2CH3.
- 6. The process of claim 1 in which the base is sodium hydride. or potassium t-butoxide.
Parent Case Info
This application claims priority from U.S. Provisional Application Ser. No. 60/235,442, filed Sep. 26, 2000.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
5858924 |
Johnson et al. |
Jan 1999 |
A |
Provisional Applications (1)
|
Number |
Date |
Country |
|
60/235442 |
Sep 2000 |
US |