Claims
- 1. A process for the preparation of a compound of the formula ##STR4## which comprises reacting a compound of the formula ##STR5## with a compound of the formula ##STR6## in a protic polar solvent, an aprotic polar solvent, or a mixture of a protic polar solvent and an aprotic polar solvent in the presence of a tetraalkyl or phenyl substituted tertraalkyl ammonium hydroxide.
- 2. The process of claim 1 wherein the tertiary alkyl or phenyl substituted tetraalkyl ammonium hydroxide is tetramethyl ammonium hydroxide, tetraethyl ammonium hydroxide, tetrabutyl ammonium hydroxide, benzyl trimethyl ammonium hydroxide, cetyltrimethylammonium hydroxide or tricaprylmethyl ammonium hydroxide.
- 3. The process of claim 2 wherein the tetraalkyl ammonium hydroxide is tetramethyl ammonium hydroxide.
- 4. The process of claim 1 wherein the protic polar solvent is a lower alkanol.
- 5. The process of claim 4 wherein the protic polar solvent is methanol, ethanol, 1 propanol or 2 propanol.
- 6. The process of claim 3 wherein the protic polar solvent is 2 propanol.
- 7. The process of claim 1 wherein the aprotic polar solvent is N,N dimethylformamide, acetonitrile, dimethylsulfoxide, N,N-dimethyl acetamide or N methylpyrrolidine.
- 8. The process of claim 7 wherein the aprotic polar solvent is N,N dimethylformamide.
- 9. The process of claim 1 wherein a mixture of protic and aprotic polar solvents is used.
- 10. The process of claim 9 wherein the ratio of protic to aprotic polar solvents is from about 2:1 to 1:2.
- 11. The process of claim 10 wherein the protic polar solvent is 2-propanol and the aprotic polar solvent is N,N dimethylformamide.
- 12. The process of claim 1 wherein Compound II is dissolved in a non reactive solvent.
- 13. The process of claim 12 wherein the non-reactive solvent is a chlorinated hydrocarbon, toluene, 2 propanol, hexane, or cyclohexane.
- 14. The process of claim 13 wherein the chlorinated hydrocarbon is chlorobenzene.
- 15. The process of claim 1 wherein the reaction is carried out at from 0.degree. to 80.degree. C.
- 16. The process of claim 15 wherein the reaction is carried out at about room temperature.
- 17. The process of claim 1 wherein from 0.8 to 1.3 moles of Compound II are employed for each mole of Compound I.
- 18. The process of claim 17 wherein approximately equimolar quantities of Compounds I and II are employed.
- 19. The process of claim 1 wherein at least two moles of the tetraalkyl ammonium hydroxide are employed for each mole of Compound II.
- 20. The process of claim 19 wherein from 2.0 to 2.1 moles of the tetraalkyl ammonium hydroxide are employed for each mole of Compound I.
- 21. The process of claim 1 wherein the reaction mixture proceeds for from 15 minutes to 24 hours following the combination of Compounds I and II.
- 22. The process of claim 21 wherein the reaction proceeds for from 15 minutes to 4 hours.
CROSS REFERENCE TO RELATED APPLICATIONS
This application is a continuation-in-part of application Ser. No. 135,885, filed Dec. 21, 1987, now abandoned.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
4251528 |
Brittain et al. |
Feb 1981 |
|
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
135885 |
Dec 1987 |
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