PROCESS FOR THE PREPARATION OF 3,4-DISUBSTITUTED-THIAZOLIDIN-2-ONES

Abstract

The present invention is directed to practical high-yielding synthetic processes for preparing 3,4-disubstituted-thiazolidin-2-ones, which do not compromise the absolute stereochemical integrity of the compounds. The present invention is also directed to novel compounds of 3,4-disubstituted-thiazolidin-2-ones. The compounds prepared by the present invention are useful in the synthesis and manufacture of compounds (such as latrunculins and/or their analogs) for treating diseases or conditions associated with inhibiting actin polymerization.

Description

Claims

1. A process for preparing a compound of Formula II,

2. A process for preparing a compound of Formula V,

3. A process for preparing a compound of Formula I,

4. The process according to claim 3, wherein said R3 is —CH2PXR8R9.

5. A process for preparing a compound of Formula I,

6. A process for preparing a compound of Formula I,

7. A process for preparing a compound of Formula I comprising the steps of:

8. A compound of Formula V:

9. The compound according to claim 8, wherein R is substituted aryl, and R1 and R2 are independently alkyl.

10. The compound according to claim 9, wherein said compound is (R)-(−)-3-(4-methoxy-benzyl)-2-oxo-thiazolidine-4-carboxylic acid methoxy-methyl-amide.

11. A compound of Formula I:

12. The compound according to claim 11, wherein said compound is (R)-4-((R)-9-(benzyloxy)-5-hydroxynon-2-ynoyl)-3-(4-methoxybenzyl)thiazolidin-2-one.