Claims
- 1. A process for the preparation of the compound of Formula VIIIa ##STR16## and pharmaceutically acceptable salts thereof comprises: Step (a) treating the racemic compound of Formula VIII ##STR17## with L-glutamic acid in a solvent to afford the compound of Formula VII; ##STR18## Step (b) treating the compound of Formula VII with a base in a solvent to afford the compound of Formula VIIIa;
- Step (c) and, if desired, converting the resulting compound of Formula VIIIa to a corresponding pharmaceutically acceptable salt by conventional means.
- 2. A process according to claim 1 wherein the solvent in Step (a) is methanol-water.
- 3. A process according to claim 1 wherein the base in Step (b) is selected from the group consisting of triethylamine, pyridine, and morpholine.
- 4. A process according to claim 3 wherein the base is triethylamine.
- 5. A process according to claim 1 wherein the solvent in Step (b) is selected from the group consisting of methanol and ethanol.
- 6. A process according to claim 5 wherein the solvent is methanol.
Parent Case Info
This is a divisional application U.S. Ser. No. 07/748,148 filed Aug. 21, 1991, now U.S. Pat. No. 5,220,031, which is a divisional application of U.S. Ser. No. 07/690,012, filed Apr. 23, 1991, which application is now U.S. Pat. No. 5,089,616.
US Referenced Citations (2)
Non-Patent Literature Citations (2)
Entry |
Elrel "Stereochemistry of Chemistry Compounds" pp. 49-55 (1962). |
Fogassy et al. "Tetrahedron Letters" vol. 21 (1980) pp. 647-650. |
Divisions (2)
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Number |
Date |
Country |
Parent |
748148 |
Aug 1991 |
|
Parent |
690012 |
Apr 1991 |
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