Claims
- 1. A process for the preparation of omeprazole, having the formula Ia: ##STR10## which comprises the step of treating the mixture of pyrmetazole, having the formula IIa: ##STR11## in a solvent; cooled to 0.degree. C. or below with magnesium monoperoxyphthalate, in an amount sufficient to convert pyrmetazole to omeprazole.
- 2. A process for the preparation of omeprazole, having the formula Ia: ##STR12## which comprises the steps of: a) treating the mixture of pyrmetazole, having the formula IIa: ##STR13## in a solvent cooled to 0.degree. C. or below, which comprises toluene; with magnesium monoperoxyphthalate, in an amount sufficient to convert pyrmetazole to omeprazole; and
- b) isolating the compound omeprazole by filtration.
- 3. The process of claim 1 wherein the solvent comprises toluene.
- 4. The process of claim 3 wherein the solvent comprises toluene, a low molecular weight alcohol and water.
- 5. The process of claim 3 which further comprises the step of isolating the compound omeprazole by filtration.
- 6. The process of claim 1 which further comprises a step of treating the mixture of pyrmetazole with an alkali base prior to the step of treating the mixture with magnesium monoperoxyphthalate.
- 7. The process of claim 6 wherein the alkali base is selected from potassium bicarbonate and sodium bicarbonate.
- 8. The process of claim 6 which further comprises the step of isolating the compound omeprazole by filtration.
RELATED APPLICATION
This is a continuation of application Ser. No. 07/777,873 filed on Oct. 15, 1991, now abandoned which is a continuation-in-part of copending application Ser. No. 764,564, filed Sep. 20, 1991, now abandoned.
US Referenced Citations (6)
Foreign Referenced Citations (1)
Number |
Date |
Country |
0174726 |
Mar 1986 |
EPX |
Continuations (1)
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Number |
Date |
Country |
Parent |
777873 |
Oct 1991 |
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Continuation in Parts (1)
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Number |
Date |
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Parent |
764564 |
Sep 1991 |
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