Claims
- 1. A method of soft tissue augmentation comprising administering to a patient in need of soft tissue augmentation an aqueous dispersion of crosslinked water-swellable polymer particles in an amount to effectively augment the affected tissue of the patient, wherein the particles are substantially homogeneous in size, wherein the particles are between about 10 micrometers in diameter and about 250 micrometers in diameter, and wherein at least 80% of the particles are spherical.
- 2. The method of claim 1, wherein the particles contain at least one water-soluble polymer selected from the group consisting of proteins, polysaccharides, peptidoglycans, glycoproteins, proteoglycans, celluloses, teichoic acids, lipopolysaccharides, and synthetic hydrophilic polymers, sodium alginate, poly(N-vinyl pyrrolidone), methyl cellulose, chitin, chitosan, agarose, dextrans, poly(vinyl alcohol), chondroitin sulfate, xanthans, dermatan sulfate, keratin sulfate, amylose, amylopectin, carrageenans, glycogen, starch, heparin sulfate, limit dextians and fragments thereof, emulsan, gellan, curdlan, hyaluronic acid, poly(ethylene oxide), bovine serum albumin, human gamma globulin, and mixtures thereof.
- 3. The method of claim 1, wherein the particles comprise at least one water-soluble polymer which is a polysaccharide.
- 4. The method of claim 3, wherein the polysaccharide is selected from the group consisting of hyaluronic acid, sodium alginate, chondroitin sulfate, celluloses, chitin, chitosan, agarose, dextrans, xanthans, dermatan sulfate, amylose, emulsan, gellan, curdlan, amylose, carrageenans, amylopectin, glycogen, starch, heparin sulfate, and limit dextrins or fragments thereof.
- 5. The method of claim 1, wherein the aqueous dispersion of crosslinked water-swellable polymer particles is administered to a patient in an amount effective to treat a defect selected from the group consisting of urinary incontinence, vesicoureteral reflux, glottic insufficiency, gastroesophageal reflux, and skin defects.
- 6. The method of claim 1, wherein the particles further comprise a bioactive agent.
- 7. A method of promoting tissue growth comprising administering to a patient in need of tissue growth an aqueous dispersion of crosslinked water-swellable polymer particles in an amount which provides a scaffold sufficient to promote tissue growth in the patient, wherein the particles are substantially homogeneous in size, wherein the particles are between about 10 micrometers in diameter and about 250 micrometers in diameter, and wherein at least 80% of the particles are spherical.
- 8. The method of claim 7, wherein the particles contain at least one water-soluble polymer selected from the group consisting of proteins, polysaccharides, peptidoglycans, glycoproteins, proteoglycans, celluloses, teichoic acids, lipopolysaccharides, and synthetic hydrophilic polymers, sodium alginate, poly(N-vinyl pyrrolidone), methyl cellulose, chitin, chitosan, agarose, dextrans, poly(vinyl alcohol), chondroitin sulfate, xanthans, dermatan sulfate, keratin sulfate, amylose, amylopectin, carrageenans, glycogen, starch, heparin sulfate, limit dextrans and fragments thereof, emulsan, gellan, curdlan, hyaluronic acid, poly(ethylene oxide), bovine serum albumin, human gamma globulin, and mixtures thereof.
- 9. The method of claim 7, wherein the particles comprise at least one water-soluble polymer which is a polysaccharide.
- 10. The method of claim 9 , wherein the polysaccharide is selected from the group consisting of hyaluronic acid, sodium alginate, chondroitin sulfate, celluloses, chitin, chitosan, agarose, dextrans, xanthans, dermatan sulfate, amylose, emulsan, gellan, curdlan, amylose, carrageenans, amylopectin, glycogen, starch, heparin sulfate, and limit dextrins or fragments thereof.
- 11. The method of claim 7, wherein the aqueous dispersion of crosslinked water-swellable polymer particles is administered to a patient in an amount effective to promote cell growth of tissue in the breast, lip, penis, bone, cartilage, or tendon.
- 12. The method of claim 7, wherein the aqueous dispersion of water-swellable polymer particles is administered to a patient in an amount effective to promote wound healing.
- 13. The method of claim 7, wherein the particles further comprise a bioactive agent.
- 14. The method of claim 1, wherein the particles contain at least one water-soluble polymer selected from the group consisting of polysaccharides, peptidoglycans, glycoproteins, proteoglycans, celluloses, teichoic acids, lipopolysaccharides, and synthetic hydrophilic polymers, sodium alginate, poly(N-vinyl pyrrolidone), methyl cellulose, chitin, chitosan, agarose, dextrans, poly(vinyl alcohol), chondroitin sulfate, xanthans, dermatan sulfate, amylose, amylopectin, carrageenans, glycogen, starch, heparin sulfate, limit dextrins and fragments thereof, emulsan, gellan, curdlan, hyaluronic acid, poly(ethylene oxide), and mixtures thereof.
- 15. The method of claim 7, wherein the particles contain at least one water-soluble polymer selected from the group consisting of polysaccharides, peptidoglycans, glycoproteins, proteoglycans, celluloses, teichoic acids, lipopolysaccharides, and synthetic hydrophilic polymers, sodium alginate, poly(N-vinyl pyrrolidone), methyl cellulose, chitin, chitosan, agarose, dextrans, poly(vinyl alcohol), chondroitin sulfate, xanthans, dermatan sulfate, amylose, amylopectin, carrageenans, glycogen, starch, heparin sulfate, limit dextrins and fragments thereof, emulsan, gellan, curdlan, hyaluronic acid, poly(ethylene oxide), and mixtures thereof.
RELATED APPLICATIONS
This application is a continuation of Ser. No. 08/989,888, U.S. Pat. No. 6,214,331 B1, filed Dec. 12, 1997 which is a continuation-in-part of U.S. patent application Ser. No. 08/659,770, filed Jun. 6, 1996 now abandoned, which is a continuation-in-part of U.S. patent application Ser. No. 08/466,676, filed Jun. 6, 1995, now abandoned.
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Continuations (1)
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Number |
Date |
Country |
Parent |
08/989888 |
Dec 1997 |
US |
Child |
09/563037 |
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US |
Continuation in Parts (2)
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Number |
Date |
Country |
Parent |
08/659770 |
Jun 1996 |
US |
Child |
08/989888 |
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US |
Parent |
08/466676 |
Jun 1995 |
US |
Child |
08/659770 |
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US |