Claims
- 1. A method of manufacturing a compound of formula (I)(R3—C)2P—L1—X—L2—P(C—R3)2, (I) in which each R is, independently, a pendant, optionally substituted, organic group through which the group is linked to tertiary carbon atom C; L1, L2 are, independently, a linking group selected from an optionally substituted C1 to C4 alkylene chain connecting the respective phosphorus atom to the group X, and X is a bridging group comprising an optionally substituted aryl moiety to which the phosphorus atoms are linked on available adjacent carbon atoms comprising: i) reacting together a compound of formula H—L1—X—L2—Hwith an organometallic compound to form an intermediate compound of formulaM—L1—X—L1—M, where M is an alkali metal atom, andii) reacting said intermediate compound with a compound of formula (R3—C)2P—L1—X—L2 —P(C—R3)2.
- 2. A method as claimed in claim 1, wherein M is sodium, potassium or lithium.
- 3. A method as claimed in claim 2, wherein the organometallic compound is a compound of formula Rm—M, where Rm is an organic group which withdraws electrons from the metal atom M.
- 4. A method as claimed in claim 1, wherein the organometallic compound is a compound of formula Rm—M, where Rm is an organic group which withdraws electrons from the metal atom M.
- 5. A method as claimed in claim 1, wherein Rm—M is generated in situ by an exchange reaction between Rm—Li and potassium or sodium alkyl oxide.
- 6. A method as claimed in claim 1, wherein the reaction between Rm—M and H—L1X—L2—H is carried out in the presence of a basic compound which is capable of forming a complex with the metal.
- 7. A method as claimed in claim 6, wherein said basic compound comprises tetramethylenediamine.
- 8. A method as claimed in claim 1, wherein said compound of formula (I) is selected from the group consisting of α,α′bis(di-t-butylphosphino)-o-xylene, bis(di-t-neopentylphosphino)-o-xylene or bis-1,2-(di-t-butylphosphino)naphthalene.
- 9. A catalyst suitable for catalyzing the carbonylation of ethylene comprising a compound of formula (R3—C)2P—L1—X—L2—P(C—R3)2, prepared by a method as claimed in claim 1, and palladium or a compound thereof.
Priority Claims (1)
Number |
Date |
Country |
Kind |
9805348 |
Mar 1998 |
GB |
|
Parent Case Info
This application is the national phase of PCT/GB99/00797, filed Mar. 16, 1999, now WO 99/47528.
PCT Information
Filing Document |
Filing Date |
Country |
Kind |
PCT/GB99/00797 |
|
WO |
00 |
Publishing Document |
Publishing Date |
Country |
Kind |
WO99/47528 |
9/23/1999 |
WO |
A |
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
4879008 |
Puckette |
Nov 1989 |
A |
Foreign Referenced Citations (5)
Number |
Date |
Country |
41 34 772 |
May 1992 |
DE |
877 592 |
Sep 1961 |
GB |
96 17856 |
Jun 1996 |
WO |
96 19434 |
Sep 1996 |
WO |
WO9909040 |
Feb 1999 |
WO |
Non-Patent Literature Citations (4)
Entry |
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Chem. Commun. by Milko van der Boom et al pp. 917-918, 1998.* |
J Am. Chem. Soc. by Miko van der Boom et al vol. 120 pp. 13415-13421, 1998. |