Claims
- 1. A process for the preparation of pearls based on a supercoolable active substance exhibiting delayed solidification upon being cooled and an indefinite crystallization point, comprising mixing a supercoolable active substance in molten form with an excipient promoting solidification and crystallization of the active substance, forcing the melt to pass through a nozzle which is subjected to a vibration, permitting the pearls formed to fall in a tower countercurrently to a gas, and collecting the pearls formed in the bottom of the tower.
- 2. A process according to claim 1, wherein the pearls have a size of 0.5 to 1.5 mm.
- 3. A process according to claim 1, wherein said nozzle is maintained at a temperature of about 90.degree. C. to about 101.degree. C.
- 4. The process according to claim 1, wherein the excipient promoting crystallization of the active substance is selected from fatty alcohols, fatty acids and their salts, glycerol esters, hydrogenated oils, polyols, waxes, polyethylene glycols and their esters.
- 5. The process according to claim 1, wherein the excipient is glycerol stearate or glycerol behenate.
- 6. The process according to claim 1, wherein a crystallization additive selected from inorganic oxides of silicon or titanium, phosphates, carbonates, talc and clays is added.
- 7. The process according to claim 1, wherein a surface-active agent is added.
- 8. The process according to claim 1, wherein the pearls are subsequently coated with a gastroresistant and/or coloring film-forming agent.
Priority Claims (1)
Number |
Date |
Country |
Kind |
90 00623 |
Jan 1990 |
FRX |
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Parent Case Info
This is a continuation of co-pending application Ser. No. 07/642,947 filed Jan. 18, 1991, now U.S. Pat. No. 5,188,838.
US Referenced Citations (9)
Foreign Referenced Citations (2)
Number |
Date |
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2725849 |
Dec 1978 |
DEX |
2725924 |
Dec 1978 |
DEX |
Continuations (1)
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Number |
Date |
Country |
Parent |
642947 |
Jan 1991 |
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