Claims
- 1. A sustained release composition comprising a biocompatible polymer and a biologically active agent characterized by a porous center and a less porous outer layer, wherein the center and the surface layer consist of essentially the same materials.
- 2. The sustained release composition of claim 1 wherein the sustained release composition is in the form of microparticles.
- 3. The sustained release composition of claim 1 wherein the biocompatible polymer is biodegradable.
- 4. The sustained release composition of claim 3 wherein the biodegradable polymer is selected from the group consisting of poly(lactide)s, poly(glycolide)s, poly(lactide-coglycolide)s, poly(lactic acid)s, poly(glycolic acid)s, poly(lactic acid-co-glycolic acid)s, poly(caprolactone), polycarbonates, polyesteramides, polyanhydrides, poly(amino acid)s, poly(ortho ester)s, polycyanoacrylates, polyamides, polyacetals, poly(ether ester)s, copolymers of poly(ethylene glycol) and poly(ortho ester)s, poly(dioxanone)s, poly(alkylene alkylate)s, biodegradable polyurethanes, blends and copolymers thereof.
- 5. The sustained release composition of claim 4 wherein said polymer is poly(lactide-co-glycolide).
- 6. The sustained release composition of claim 1 wherein the biocompatible polymer is non-biodegradable.
- 7. The sustained release composition of claim 1 wherein the biologically active agent is a protein, peptide or nucleic acid.
- 8. A method of providing a therapeutically effective level of an active agent in a subject for a sustained period comprising administering to the subject a dose of the sustained release composition of claim 1.
RELATED APPLICATION
[0001] This application is a continuation of Application No. 09/638,165, filed Aug. 10, 2000. The entire teachings of the above application is incorporated herein by reference.
Continuations (1)
|
Number |
Date |
Country |
Parent |
09638165 |
Aug 2000 |
US |
Child |
09801272 |
Mar 2001 |
US |