Claims
- 1. A process for the production of a compound of formula I, ##STR3## in which R signifies lower alkyl, which comprises reacting a compound of formula II, ##STR4## with a compound of formula III,
- R--OH III
- in which R is as defined above,
- in the presence of boron trifluoride or a complex form thereof.
- 2. A process according to claim 1, in which the reaction is effected in an organic solvent selected from a nitrile, a nitroalkane and a sulphone.
- 3. A process according to claim 1 in which the compound of Formula III is methanol, ethanol, n-propanol, isopropanol, or n-butanol.
- 4. A process according to claim 1 in which the boron trifluoride complex form is a complex of boron trifluoride with a compound of Formula III.
- 5. A process for the production of a compound of formula I, ##STR5## in which R signifies methyl, which comprises reacting a compound of Formula II, ##STR6## with methyl alcohol in the presence of boron trifluoride or a boron trifluoride complex with methyl alcohol, wherein an equimolar amount or slight excess of methyl alcohol is used in relation to the boron trifluoride.
- 6. A process according to claim 5, in which the reaction is carried out in an organic solvent selected from acetonitrile, propionitrile, nitromethane, and sulfolane.
- 7. A process according to claim 5, in which the reaction is carried out at a temperature between 0.degree. and 70.degree. C.
- 8. A process according to claim 5, in which the reaction is carried out between room temperature and 50.degree. C.
- 9. A process for the production of (6R,7R)-7-amino-3-methoxymethyl-3-cephem-4-carboxylic acid according to claim 5, which comprises reacting 7-aminocephalosporanic acid with methanol in the presence of a boron trifluoride complex formed by boron trifluoride gas and methanol.
- 10. A process for the production of a cephalosporin antibiotic which comprises:
- a) reacting a compound of Formula II, ##STR7## with a compound of formula III
- R--OH III
- where R is lower alkyl, in the presence of boron trifluoride or a boron trifluoride complex to obtain a compound of formula I ##STR8## and b) acylating the compound of formula I with the 7-amino substituent of the cephalosporin antibiotic.
Priority Claims (1)
Number |
Date |
Country |
Kind |
1669/85 |
Jun 1985 |
ATX |
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Parent Case Info
This is a continuation of application Ser. No. 08/139,479, filed Oct. 20, 1993, now abandoned, which in turn is a continuation of application Ser. No. 07/917,570, filed Jul. 20,1992, now abandoned, which in turn is a continuation of application Ser. No. 07/731,696, filed Jul. 17, 1991, now abandoned, which in turn is a continuation of application Ser. No. 07/515,292, filed Apr. 27, 1990, now abandoned, which in turn is a continuation of application Ser. No. 07/427,656, filed Oct. 26, 1989, now abandoned, which in turn is a continuation of application Ser. No. 07/369,431, filed Jun. 21, 1989, now abandoned, which in turn is a continuation of application Ser. No. 07/307,030, filed Feb. 3, 1989 now abandoned, which in turn is a continuation of application Ser. No. 06/870,258, filed Jun. 3, 1986, now abandoned.
US Referenced Citations (4)
Number |
Name |
Date |
Kind |
3665003 |
Kennedy et al. |
May 1972 |
|
4317907 |
Saikawa et al. |
Mar 1982 |
|
4482710 |
Fujimoto et al. |
Nov 1984 |
|
4902793 |
Nishikido et al. |
Feb 1990 |
|
Continuations (8)
|
Number |
Date |
Country |
Parent |
139479 |
Oct 1993 |
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Parent |
917570 |
Jul 1992 |
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Parent |
731696 |
Jul 1991 |
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Parent |
515292 |
Apr 1990 |
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Parent |
427656 |
Oct 1989 |
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Parent |
369431 |
Jun 1989 |
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Parent |
307030 |
Feb 1989 |
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Parent |
870258 |
Jun 1986 |
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