Claims
- 1. A process wherein the compound of formula (C):
- 2. A process as claimed in claim 1, wherein R5 and R6 together with the N atom to which they are attached represent a saturated 6-membered N-containing ring which is fused to an optionally substituted benzene or pyridine ring.
- 3. A process as claimed in claim 2, wherein R5 and R6 together with the N atom to which they are attached represent a tetrahydroisoquinoline ring system.
- 4. A process as claimed in claim 3, wherein R5 and R6 together with the N atom to which they are attached represent 5-methylsulfonylamino tetrahydroisoquinoline.
- 5. A process as claimed in claim 1, wherein the reaction is carried out in the presence of an aqueous base.
- 6. A process as claimed in claim 5, wherein the aqueous base is sodium hydroxide.
- 7. A process as claimed in claim 1, wherein the compound of formula (C) is N-(2-amidino-1,2,3,4-tetrahydro-5-isoquinolyl)methanesulfonamide.
- 8. A process wherein the compound of formula (B):
- 9. A process as claimed in claim 8, wherein R9 is iodine.
- 10. A process as claimed in claim 8, wherein the pyridine derivative is a pyridyl boronate.
- 11. A process as claimed in claim 8, wherein the reaction is carried out in a polar aprotic solvent.
- 12. A process as claimed in claim 11, wherein the polar aprotic solvent is dioxane.
- 13. A process as claimed in claim 8, wherein the reaction is carried out in the presence of a catalyst.
- 14. A process as claimed in claim 13, wherein the catalyst is a palladium (0) catalyst.
- 15. A process as claimed in claim 8, wherein the product is 6-fluoro-3,4-dimethoxy-2-(2-pyridyl)benzonitrile.
Priority Claims (1)
Number |
Date |
Country |
Kind |
0112061.7 |
May 2001 |
GB |
|
Parent Case Info
[0001] This application claims priority to U.S. Ser. No. 10/144,337, filed May 13, 2002, now allowed, which claims priority to U.S. Provisional No. 60/301,750, filed Jun. 28, 2001, which claims priority to British Application Serial No. 0112061.7, filed May 18, 2001.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60301750 |
Jun 2001 |
US |
Divisions (1)
|
Number |
Date |
Country |
Parent |
10144337 |
May 2002 |
US |
Child |
10775001 |
Feb 2004 |
US |