Claims
- 1. A process for treating impure FR-1923 substance to remove undesired components which comprises the steps of contacting an aqueous solution thereof at a pH of 4 - 8 with a macroporous nonionic adsorption resin selected from styrene-divinylbenzene copolymer and acrylic ester polymer, said resin having an average pore diameter of 4 to 100 nm and a surface from 100 to 1000 m.sup.2 per gram, until said resin is saturated by FR-1923 substance, and thereafter contacting further aqueous solution of FR-1923 substance containing impurities at a pH of about 4 - 8 with said saturated resin to adsorb at least some of said second impurities, and recovering said further FR-1923 substance from the passed through solution.
- 2. A process according to claim 1 wherein said aqueous solutions are filtrates of culture broth.
- 3. A process according to claim 1 wherein said aqueous solutions are pre-extracted culture solutions.
- 4. A process according to claim 1 wherein said aqueous solutions are made from crude solid material of FR-1923 substance.
- 5. A process according to claim 1 wherein said aqueous solutions contain coloring materials as said impurities.
- 6. A process according to claim 1 wherein said aqueous solution contains said FR-1923 substance and an isomer thereof.
- 7. A process according to claim 1 wherein said resin is acrylic ester polymer.
CROSS-REFERENCE TO RELATED APPLICATION
The present invention is a continuation-in-part application of copending application Ser. No. 562,928, filed Mar. 28, 1975, now abandoned.
US Referenced Citations (3)
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
562928 |
Mar 1975 |
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