Claims
- 1. A method for the racemization of an enantiomer, or an enantiomerically enriched mixture of a compound of formula,
- 2. The method of claim 1, wherein the C1-C6 primary alcohol is methanol or ethanol.
- 3. The method of claim 2, wherein the C1-C6 primary alcohol is ethanol.
- 4. The method of claim 1, wherein the alkali alkoxide is a sodium or potassium alkoxide.
- 5. The method of claim 1, wherein the alkali alkoxide of a C1-C6 primary alcohol is sodium ethoxide.
- 6. The method of claim 1, wherein the racemization reaction temperature is less than 200° C.
- 7. The method of claim 1, wherein the racemization reaction temperature is less than 100° C.
- 8. The method of claim 1, wherein the racemization reaction temperature is at the boiling point of the reaction mixture.
- 9. The method of claim 1, wherein after the compound is contacted with the alkali alkoxide of a C1-C6 primary alcohol, the method further comprises the step of hydrolysing the resulting material by treatment with dilute acid.
- 10. The method of claim 1, further comprising the step of subjecting the product obtained by racemization to optical resolution to obtain a pure enantiomer of the compound of Formula II.
- 11. The method of claim 10, further comprising the step of converting the product obtained by racemization to a compound of Formula I(a), I(b), I(c) or I(d).
- 12. The method of claim 1, wherein the enantiomer has an R-configuration.
- 13. The method of claim 1, wherein the enantiomer has an S-configuration.
CROSS REFERENCE TO RELATED APPLICATIONS
[0001] This application claims priority under 35 U.S.C. §119(e) to U.S. Ser. No. 60/332,148, filed Nov. 20, 2002, which is incorporated by reference in its entirety for all purposes.
Provisional Applications (1)
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Number |
Date |
Country |
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60332148 |
Nov 2001 |
US |