Claims
- 1. A process for the preparation of a 2-lithiobenzotrifluoride of Formula I whereinX represents F, Cl or OR and R represents a C1-C4 alkyl group optionally substituted with a C1-C4 alkoxy group which comprises contacting a benzotrifluoride of Formula II wherein X is as previously definedwith an alkyl lithium in an inert organic solvent in the presence of a catalytic amount of a primary or secondary C1-C8 alkyl amine, wherein the molar amount of alkyl lithium is less than the sum of the molar quantities of the benzotrifluoride and of the primary or secondary alkyl amine, and equilibrating the reaction mixture.
- 2. The process of claim 1 in which the alkyl lithium is n-butyl lithium.
- 3. The process of claim 1 in which the C1-C8 alkyl amine is a secondary amine.
- 4. The process of claim 3 in which the C1-C8 alkyl amine is di(i-propyl) amine.
- 5. The process of claim 1 in which the inert organic solvent is an hydrocarbon, an ether or mixtures thereof.
- 6. The process of claim 5 in which the solvent is a mixture of tetrahydrofuran and octanes.
- 7. The process of claim 1 in which X represents OR and R represents 1-ethoxyethyl.
- 8. The process of claim 1 in which the equilibrated reaction mixture is further contacted with an electrophilic reagent.
Parent Case Info
This application claims benefit of provisional application 60/211,415, filed Jun. 14, 2000.
US Referenced Citations (3)
Number |
Name |
Date |
Kind |
5272128 |
Rosen et al. |
Dec 1993 |
A |
5500405 |
Rosen et al. |
Mar 1996 |
A |
5858924 |
Johnson et al. |
Jan 1999 |
A |
Provisional Applications (1)
|
Number |
Date |
Country |
|
60/211415 |
Jun 2000 |
US |