Claims
- 1. A process for making 4,5-diaminopyrazole derivative compounds of the formula (I) ##STR10## wherein R.sub.1 and R.sub.2 are independently selected from the group consisting of hydrogen, alkyl radicals having one to six carbon atoms and hydroxyalkyl radicals having two to four carbon atoms, provided that R.sub.2 may not be tertiary butyl, said process comprising the steps of:
- a) converting 3,5-dibromo-4-nitropyrazole with a member selected from the group consisting of benzyl halide, benzyl sulfate, an alkyl halide radical having one to six carbon atoms, an alkyl sulfate radical having one to six carbon atoms, a hydroxyalkyl halide radical having two to four carbon atoms and a hydroxyalkyl sulfate radical having two to four carbon atoms to form a compound of formula (II): ##STR11## wherein R.sub.3 is selected from the group consisting of alkyl radicals having one to six carbon atoms, hydroxyalkyl radicals having two to four carbon atoms and benzyl radicals;
- b) reacting said compound of said formula (II) formed in step a) with a member selected from the group consisting of benzyl amine, alkyl amines having one to six carbon atoms and hydroxyalkyl amines having two to four carbon atoms to form a compound of the formula (III): ##STR12## wherein R.sub.3 and R.sub.4 are independently selected from the group consisting of alkyl radicals having one to six carbon atoms, hydroxyalkyl radicals having two to four carbon atoms and benzyl radicals; and
- c) catalytically hydrogenating the compound of formula (III) formed in step b) to obtain a compound of the formula (I).
- 2. The process as defined in claim 1 wherein said catalytically hydrogenating is performed using a palladium-on-activated-carbon catalyst with a palladium content of 10 percent by weight of said catalyst.
Priority Claims (1)
Number |
Date |
Country |
Kind |
42 34 885.4 |
Oct 1992 |
DEX |
|
Parent Case Info
This is a division of application Ser. No. 08/244,553 filed on May 27, 1994 which is a 371 of a PCT/EP93/02644.
Foreign Referenced Citations (1)
Number |
Date |
Country |
WO9408969 |
Apr 1994 |
WOX |
Divisions (1)
|
Number |
Date |
Country |
Parent |
244553 |
May 1994 |
|