Claims
- 1. A compound of Formula IX ##STR28## wherein R.sup.8 or R.sup.9 is independently
- alkyl of from one to ten carbon atoms,
- cyclopropyl,
- cyclobutyl,
- cyclopentyl,
- cyclohexyl,
- benzyl or
- phenyl or
- R.sup.8 and R.sup.9 together are
- --(CH.sub.2).sub.4 --,
- --(CH.sub.2).sub.5 --,
- --(CH(R.sup.10)--CH.sub.2).sub.3 --,
- --(CH(R.sup.10)--CH.sub.2).sub.4 --,
- --(CH(R.sup.10)--(CH.sub.2).sub.2 --CH(R.sup.10))--,
- --(CH(R.sup.10)--(CH.sub.2).sub.3 --CH(R.sup.10))--,
- --CH.sub.2 --CH.sub.2 --O--CH.sub.2 --CH.sub.2 --,
- --CH(R.sup.10)--CH.sub.2 --O--CH.sub.2 --CH.sub.2 --,
- --CH(R.sup.10)--CH.sub.2 --O--CH.sub.2 --CH(R.sup.10)--,
- wherein R.sup.10 is alkyl of from one to four carbon atoms provided R.sup.8 and R.sup.9 are not both methyl; and
- R.sup.11 or R.sup.12 is independently
- alkyl of from one to three carbon atoms or
- phenyl or
- R.sup.11 and R.sup.12 are taken together as --(CH.sub.2).sub.n -- wherein n is 4 or 5.
- 2. A compound according to claim 1 wherein R.sup.8 and R.sup.9 are phenyl.
- 3. A compound according to claim 1 wherein R.sup.8 and R.sup.9 are phenylmethyl.
- 4. A compound according to claim 1 wherein R.sup.8 and R.sup.9 are combined as --(CH.sub.2).sub.5 --.
- 5. A compound according to claim 1 wherein R.sup.8 is butyl and R.sup.9 is methyl.
- 6. A compound according to claim 1 wherein R.sup.8 is 1,1-dimethylethyl and R.sup.9 is phenylmethyl.
- 7. A compound according to claim 1 wherein R.sup.8 and R.sup.9 are ethyl.
- 8. A compound according to claim 1 wherein R.sup.8 and R.sup.9 are 2-methylphenyl.
- 9. A compound according to claim 1 wherein R.sup.8 and R.sup.9 are 4-methylphenyl.
- 10. A compound according to claim 1 selected from the group consisting of:
- (R)-6-cyano-5-hydroxy-3-oxo-N,N-diphenylhexanamide;
- (R)-6-cyano-N,N-diethyl-5-hydroxy-3-oxohexanamide;
- (R)-6-cyano-5-hydroxy-3-oxo-N,N-bis (phenylmethyl)hexanamide;
- (R)-N-butyl-6-cyano-5-hydroxy-N-methyl-3-oxohexanamide;
- (R) -6-cyano-N-(1,1-dimethylethyl)-5-hydroxy-3-oxo-N-(phenylmethyl)hexanamide;
- (R)-.epsilon.-hydroxy-.alpha.,.gamma.-dioxo-1-piperidineheptanenitrile; and
- (R)-.epsilon.-hydroxy-.alpha.,.gamma.-dioxo-1-pyrrolidineheptanenitrile.
Parent Case Info
This is a division application of U.S. Ser. No. 08/025,701 filed Mar. 3, 1993, now U.S. Pat. No. 5,298,627.
US Referenced Citations (10)
Non-Patent Literature Citations (3)
Entry |
J. Med. Chem., 1991, 34, 357-366 B. D. Roth, et al. |
Tetrahedron Letters, vol. 33, No. 17, pp. 2283-2284 1992, K. L. Baumann, et al. |
Tetrahedron Letters, vol. 33, No. 17, pp. 2279-2282 1992, P. L. Brower, et al. |
Divisions (1)
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Number |
Date |
Country |
Parent |
25701 |
Mar 1993 |
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