Claims
- 1. A compound of Formula IV ##STR48## wherein R.sub.7 and R.sub.8 are independently hydrogen, alkyl of from one to three carbon atoms, phenyl or R.sub.7 and R.sub.8 are taken together as --(CH.sub.2).sub.n --, wherein n is 4 or 5, and R.sub.8 is alkyl of from one to eight carbon atoms, a three- to six-membered cycloalkyl group, or .alpha.,.alpha.-dimethylbenzyl.
- 2. A compound according to claim 1 wherein R.sub.9 is ##STR49##
- 3. A compound according to claim 1 wherein R.sub.7 and R.sub.8 are methyl, and R.sub.9 is isopropyl.
- 4. A compound according to claim 1 wherein R.sub.7 and R.sub.8 are methyl, and R.sub.9 is tertiary butyl.
- 5. A compound according to claim 1 selected from the group consisting of (4R-cis)-1,1-dimethylethyl 6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxane-4-acetate; 2R-(2.alpha.,4.alpha.,6.alpha.)]-1,1-dimethylethyl 6-(2-aminoethyl)-2-phenyl-1,3-dioxane-4-acetate; [2S-(2.alpha.,4.beta.,6.beta.)]-1,1-dimethylethyl 6-(2-aminoethyl)-2-phenyl-1,3-dioxane-4-acetate; (7R-cis)-1,1-dimethyethyl 9-(2-aminoethyl)-6,10-dioxaspiro[4.5]decane-7-acetate; (2R-cis)-1,1-dimethylethyl 4-(2-aminoethyl)-1,5-dioxaspiro[5.5]undecane-2-acetate; (4R-cis)-1,1-dimethylethyl 4-(2-aminoethyl)-1,3-dioxane-4-acetate; [2R-(2.alpha.,4.alpha.,6.alpha.)]-1,1-dimethylethyl 6-(2-aminoethyl)-2-methyl-1,3-dioxane-4-acetate; and [2S-(2.alpha.,4.beta.,6.beta.)]-1,1-dimethylethyl 6-(2-aminoethyl)-2-methyl-1,3-dioxane-4-acetate.
- 6. A compound of Formula XXI ##STR50## wherein R.sub.7 and R.sub.8 are independently hydrogen alkyl of from one to three carbon atoms, phenyl or R.sub.7 and R.sub.8 are taken together as --(CH.sub.2).sub.n --, wherein n is 4 or 5.
- 7. A compound according to claim 6 selected from the group consisting of (4R-cis)-6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxane-4-acetic acid; [2R-(2.alpha.,4.alpha.,6.alpha.)]-6-(2-aminoethyl)-2-phenyl-1,3-dioxane-4-acetic acid; [2S-(2.alpha.,4.beta.,6.beta.)]-6-(2-aminoethyl)-2-phenyl-1,3-dioxane-4-acetic acid; (7R-cis)-9-(2-aminoethyl)-6,10-dioxaspiro [4.5]decane-7-acetic acid; (2R-cis)-4-(2-aminoethyl)-1,5-dioxaspiro[5.5]undecane-2-acetic acid; (4R-cis)-4-(2-aminoethyl)-1,3-dioxane-4-acetic acid; [2R-(2.alpha.,4.alpha.,6.alpha.)]-6-(2-aminoethyl)-2-methyl-1,3-dioxane-4-acetic acid; and [2S-(2.alpha.,4.beta.,6.beta.)]-6-(2-aminoethyl)-2-methyl-1,3-dioxane-4-acetic acid.
Parent Case Info
This is for a divisional application of U.S. Ser. No. 07/792,311 filed Nov. 14, 1991, now allowed, which is a divisional application of U.S. Ser. No. 07/595,461, filed Oct. 9, 1990, now U.S. Pat. No. 5,093,040, which is a divisional application of U.S. Ser. No. 07/303,733, filed Feb. 1, 1989, now U.S. Pat. No. 5,003,080, which is a continuation-in-part application of U.S. Ser. No. 07/158,439, filed Feb. 22, 1988, now abandoned.
US Referenced Citations (4)
Divisions (3)
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Number |
Date |
Country |
Parent |
792311 |
Nov 1991 |
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Parent |
595461 |
Oct 1990 |
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Parent |
303733 |
Feb 1989 |
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Continuation in Parts (1)
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Number |
Date |
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Parent |
158439 |
Feb 1988 |
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