Fitzhugh et al, Scalable Route to Resolving Monoesters of dl 5-Formyl 5,6,7,8-Tetrahydropteroylmono-L-Glutamic Acid, Pteridines vol. 3, pp. 99-100. |
Choi et al, Resolution of the Stereoisomers of Leucovorin and Methyltetrahydrofolate by Chiral High-Performance Liquid Chromatography, (1988), Analytical Biochemistry 168, pp. 398-404. |
Rees et al, Asymmetric Reduction of Dihydrofolate Using Dihydrofolate Reductase and Chiral Boron-Containing Compounds, Tetrahedron, vol. 42, No. 1, pp. 117-136, (1986). |
Cosulich et al J. Am. Chem. Soc., (1952) 74, 4215, Diastereoisomers of Leucovorin. |
Kaufman et al, Chromatrographic Separaton of the Diastereoisomers of dl, L-5,10-Methylenetetrahydrofolate, The Journal of Biological Chemistry, (1963) vol. 238, No. 4, pp. 1498-1500. |
Hillcoat et al, The Reduction of Folate by Borohydride and by Dithionite, Biochemical and Biophysical Research Communications, (1964), vol. 15 No. 4 pp. 303-307. |
Matthews et al, Inhibition of Pig Liver Methylenetetrahydrofolate Reductase by Dihydrofolate: Some Mechanistic and Regulatory Implications, (1979) Biochemistry, vol. 18, No. 22, pp. 4845-4851. |
Feeney et al, Hydrogen-1 Nuclear Magnetic Resonance Study of the Complexes fo Two Distereoisomers of Folinic Acid with Dihydrofolate Reductase, (1981) Biochemistry, vol. 20, pp. 1837-1842. |
Wainer et al,Direct resolution of the stereoisomers of leucovorin and 5-methyltetrahydrofolate using a bovine serum albumin high-performance liquid chromatographic chiral stationary phase coupled to an achiral phenyl column, (1988) Journal of Chromatography, vol. 424, pp. 158-162. |
Fitzhugh et al, A New and Facile Synthetic Route to N.sup.5 -Formyl Tetrahydropteroylpoly-L-Glutamates.sup.1, (1991), Bioorganic & Medicinal Chemistry Letters, vol. 1, No. 3, pp. 155-158. |
Fitzhugh and Akee, Chem. Abstr. vol 117 Entry 251731t (1992). |
Fitzhugh and Chmurny and Klose Chem. Abst. vol. 115 Entry 159734g (1991). |