Claims
- 1. A process for the preparation of a compound of formula (VI):
- 2. A process according to claim 1, wherein the hydrogen cyanide is prepared from a metal cyanide salt in the presence of an acid.
- 3. A process according to claim 1, performed under increased pressure.
- 4. A process according to claim 1, wherein the compound of formula (I) is prepared by reacting a compound of formula (II):
- 5. A process according to claim 1, wherein the compound of formula (I) is prepared by reacting a compound of formula (IV):
- 6. A process according to claim 1, wherein the compound of formula (VI) is oxidized and optionally reacted with a base to prepare a compound of formula (X) or (XI):
- 7. A process according to claim 2, performed under increased pressure.
- 8. A process according to claim 2, wherein the compound of formula (VI) is oxidized and optionally reacted with a base to prepare a compound of formula (X) or (XI):
- 9. A process according to claim 3, wherein the compound of formula (VI) is oxidized and optionally reacted with a base to prepare a compound of formula (X) or (XI):
- 10. A process according to claim 4, wherein the compound of formula (VI) is oxidized and optionally reacted with a base to prepare a compound of formula (X) or (XI):
- 11. A process according to claim 5, wherein the compound of formula (VI) is oxidized and optionally reacted with a base to prepare a compound of formula (X) or (XI):
- 12. A process according to claim 1, wherein R1 represents haloalkyl, haloalkoxy or —SF5; W represents —CR3; and R3 represents halogen.
- 13. A process according to claim 12, wherein R1 represents trifluoromethyl, trifluoromethoxy or —SF5; W represents —CR3; and R3 represents halogen.
- 14. A process according to claim 1, wherein R1 represents trifluoromethyl, W represents —CR3 and R2 and R3 represent chlorine.
- 15. A process for the preparation of a compound of formula (I):
- 16. A process according to claim 15 wherein, in process (A), R5 and R6 each represent methyl or ethyl.
- 17. A process according to claim 15 wherein, in process (A) or (B), the acid addition salt of the compound of formula (III) is the salt formed from a strong acid.
- 18. A process according to claim 15 wherein, in process (A) or (B), water is present.
- 19. A process according to claim 15 wherein, in process (C), the oxidant is a metal salt or oxide.
- 20. A process according to claim 15 wherein, in process (C), the process is conducted in a solvent.
- 21. A process according to claim 15 wherein, in process (C), the molar ratio of oxidant to compound of formula (V) is from 0.01:1 to 5:1.
- 22. A process according to claim 15, wherein process (C) is followed by reacting a compound of formula (I) with a source of hydrogen cyanide to prepare a compound of formula (VI):
- 23. A process according to claim 15 wherein, in process (C), the compound of formula (V) is prepared by reacting a compound of formula (III) wherein R1, R2 and W are as defined in claim 15, with acrylonitrile of formula (VII):
- 24. A process according to claim 15, wherein R1 is haloalkyl or haloalkoxy.
- 25. A process according to claim 24, wherein R1 is trifluoromethyl or trifluoromethoxy.
- 26. A process according to claim 15, wherein R2 is halogen.
- 27. A process according to claim 26, wherein R1 is chlorine or bromine.
- 28. A process according to claim 15, wherein, in process (C), R7 is methyl or ethyl.
- 29. A process according to claim 19, which is conducted in a solvent.
- 30. A process according to claim 19, wherein the molar ratio of oxidant to compound of formula (V) is from 0.01:1 to 5:1.
- 31. A process according to claim 20, wherein the molar ratio of oxidant to compound of formula (V) is from 0.01:1 to 5:1.
- 32. A process according to claim 21, wherein the molar ratio of oxidant to compound of formula (V) is from 1:1 to 3:1.
- 33. A process according to claim 30, wherein the molar ratio of oxidant to compound of formula (V) is from 1:1 to 3:1.
- 34. A process according to claim 31, wherein the molar ratio of oxidant to compound of formula (V) is from 1:1 to 3:1.
- 35. A process according to claim 19, wherein the compound of formula (V) is prepared by reacting a compound of formula (III) wherein R1, R2 and W are as defined in claim 19, with acrylonitrile of formula (VII):
- 36. A process according to claim 20, wherein the compound of formula (V) is prepared by reacting a compound of formula (III) wherein R1, R2 and W are as defined in claim 20, with acrylonitrile of formula (VII):
- 37. A process according to claim 21, wherein the compound of formula (V) is prepared by reacting a compound of formula (III) wherein R1, R2 and W are as defined in claim 7, with acrylonitrile of formula (VII):
- 38. A process according to claim 22, wherein the compound of formula (V) is prepared by reacting a compound of formula (III) wherein R1, R2 and W are as defined in claim 22, with acrylonitrile of formula (VII):
Priority Claims (2)
Number |
Date |
Country |
Kind |
98 420069.1 |
Apr 1998 |
EP |
|
98 420070.9 |
Apr 1998 |
EP |
|
CROSS-REFERENCE TO RELATED APPLICATIONS
[0001] This application is a divisional of U.S. application Ser. No. 09/673,801, filed Dec. 22, 2000, now allowed, incorporated by reference herein in its entirety and relied upon, which is a national stage filing under 35 U.S.C. §371 of International Application No. PCT/EP99/02834, filed Apr. 14, 1999, and claims priority under 35 U.S.C. §119 to Patent Application No. 98/420069.1, filed Apr. 20, 1998, in the European Patent Office, and Patent Application No. 98/420070.9, filed Apr. 20, 1998, in the European Patent Office.
Divisions (1)
|
Number |
Date |
Country |
Parent |
09673801 |
Dec 2000 |
US |
Child |
10120479 |
Apr 2002 |
US |