Claims
- 1. A method for promoting wound healing in a mammal having a wound, which method comprises:
- applying to said wound a matrix having a density of about 0.01 to about 0.3 g/cm.sup.3, a thickness of about 1-20 mm, and having pores at least 80% of which are at least 35 um in diameter, wherein said matrix comprises
- fibrillar atelopeptide collagen, wherein said fibrils are about 50-200 nm in diameter, and are not chemically cross-linked.
- 2. The method of claim 1, wherein said matrix further comprises a biological growth factor in a wound-healing effective amount.
- 3. The method of claim 2 wherein said growth factor comprises TGF-beta1, TGF-beta2, PDGF-AA, PDGF-AB, PDGF-BB, EGF, acidic FGF, basic FGF, TGF-alpha, connective tissue activating peptides, beta-thromboglobulin, insulin-like growth factors, tumor necrosis factors, interleukins, nerve growth factor, or interferons.
- 4. The method as claimed in claim 2, wherein the biological growth factor is a TGF-beta.
CROSS-REFERENCES
This application is a divisional application of pending U.S. application Ser. No. 07/213,726 filed Jun. 30, 1988 U.S. Pat. No. 5,024,841 to which application applicants claim priority under 35 USC .sctn.120 and which application is incorporated herein by reference in its entirety.
US Referenced Citations (18)
Foreign Referenced Citations (1)
Number |
Date |
Country |
WO8504412 |
Oct 1985 |
WOX |
Non-Patent Literature Citations (1)
Entry |
C. J. Doillon et al., J Biomed Mat Res (1986) 20:1219-28. |
Divisions (1)
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Number |
Date |
Country |
Parent |
213726 |
Jun 1988 |
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