Claims
- 1. A process for producing a pyridoindole compound of the formula: ##STR6## where R.sup.1 is hydrogen, a lower alkyl group or a lower alkenyl group, R.sup.2 is hydrogen, a lower alkyl group or halogen, and R.sup.3 is an imidazolyl group optionally substituted by a lower alkyl moiety,
- or a salt thereof, by reacting a compound of the formula: ##STR7## where R.sup.1 and R.sup.2 are respectively as indicated above, or a salt thereof with a compound of the formula: ##STR8## where R.sub.a.sup.3 is an imidazolyl group substituted with an imino protective group, optionally substituted by a lower alkyl moiety, and X is halogen,
- or a salt thereof and then subjecting to a removal reaction of an imino protective group.
- 2. A process for producing a pyridoindole compound or a salt thereof of claim 1, wherein R.sup.1 is a lower alkyl group, R.sup.2 is hydrogen, R.sup.3 is an imidazolyl group substituted with a lower alkyl group, and R.sub.a.sup.3 is an imidazolyl group substituted with an imino protective group, optionally substituted by a lower alkyl group.
- 3. A process for producing an optically active pyridoindole derivative of the formula: ##STR9## where R.sup.1 is hydrogen, a lower alkyl group or a lower alkenyl group, R.sup.2 is hydrogen, a lower alkyl group or halogen, and R.sup.3 is an imidazolyl group optionally substituted by a lower alkyl moiety,
- or a salt thereof, by reacting a racemic mixture of a pyridoindole derivative of the formula: ##STR10## where R.sup.1, R.sup.2, and R.sup.3 are respectively as indicated above, or a salt thereof with (1R)-(-)-10-camphorsulfonic acid.
- 4. A process for producing an optically active pyridoindole derivative or salt thereof of claim 3, wherein R.sup.1 is a lower alkyl group, R.sup.2 is hydrogen, and R.sup.3 is an imidazolyl group optionally substituted by a lower alkyl.
Priority Claims (2)
Number |
Date |
Country |
Kind |
7-269154 |
Sep 1995 |
JPX |
|
7-326588 |
Nov 1995 |
JPX |
|
CROSS REFERENCE
This application is a 371 of PCT/JP96/02692 filed Sep. 18, 1996.
PCT Information
Filing Document |
Filing Date |
Country |
Kind |
102e Date |
371c Date |
PCT/JP96/02692 |
9/18/1996 |
|
|
4/21/1998 |
4/21/1998 |
Publishing Document |
Publishing Date |
Country |
Kind |
WO97/11074 |
3/27/1997 |
|
|
Non-Patent Literature Citations (3)
Entry |
New 5HT3 (Serotin-3) receptor Antagonist II. Chem .Pharm. Bull. vol. 42 (12) pp. 2556-2564; by Masyuki Kato et al, Aug. 18, 1994. |
New 5HT3 (Serotin-3) receptor Antagonist I. Chem .Pharm. Bull. vol 42 (12) pp. 2546-2555; by Masyuki Kato et al, Aug. 18, 1994. |
New 5HT3 (Serotin-3) receptor Antagonist III. Chem .Pharm. Bull. vol. 43 (8) pp. 1346-1350; by Masyuki Kato et al, Apr. 4, 1995. |