Claims
- 1. A process for the preparation of a compound of formula I: wherein:R1 is hydrogen or a lower alkyl, R2 is hydrogen or a lower alkyl, R4 is a lower alkyl, hydrogen, or a lower alkoxy, R5 is hydrogen or an alcohol protective group; comprising: (i) reacting a compound of formula II: wherein:R1, R4 and R5 are as defined above, with 1,1′-carbonyldiimidazole; and (ii) reacting the mixture resulting from step (i) with a compound of formula R2NH2, wherein R2 is as defined above, so that the compound of formula I is produced.
- 2. The process of claim 1 wherein:R1 and R2 are methyl, R4 is hydrogen, and R5 is benzyl.
- 3. The process of claim 1 wherein said alcohol protective group is benzyl or a benzyl group substituted with nitro, a lower alkyl or a lower alkoxy.
Parent Case Info
This application is a division of application Ser. No. 09/985,269, filed Nov. 2, 2001, the entire content of which is hereby incorporated by reference in this application.
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