PRODUCTION OF HUMAN SOLUBLE CD4 PROTEIN IN CHICKEN EGGS

Information

• Research Project
• 3489113

• ApplicationId

  3489113

• Core Project Number

  R43AI028643

• Full Project Number

  1R43AI028643-01

• Serial Number

  28643

• FOA Number

• Sub Project Id

• Project Start Date

  9/30/1989 - 35 years ago

• Project End Date

  3/31/1990 - 35 years ago

• Program Officer Name

• Budget Start Date

  9/30/1989 - 35 years ago

• Budget End Date

  3/31/1990 - 35 years ago

• Fiscal Year

  1989

• Support Year

  1

• Suffix

• Award Notice Date

  9/25/1989 - 35 years ago

Organizations

• TSI CORPORATION

Soluble CD4 is considered to have a great potential in AIDS therapy including treatment and prevention of AIDS. In vitro studies have estimated that a large excess (1000:1) of soluble CD4 is needed to achieve a significant reduction in infectious particles. It is likely that an excess of soluble CD4 is needed constantly over prolonged periods during therapy in AIDS patients. Conventional methods of production (cell culture and bacteria) may not be suitable to produce soluble CD4 in large amounts in the least expensive way. We propose to produce soluble CD4 in transgenic chicken eggs using chicken ovalbumin promoter-enhancer signals fused to the coding sequences of soluble CD4 domain. Use of chicken eggs as bioreactors to produce soluble CD4 will be highly innovative and very inexpensive.

IC Name

• Activity

  R43

• Administering IC

  AI

• Application Type

  1

• Direct Cost Amount

• Indirect Cost Amount

• Total Cost

• Sub Project Total Cost

• ARRA Funded

• CFDA Code

  855

• Ed Inst. Type

• Funding ICs

• Funding Mechanism

• Study Section

  SSS

• Study Section Name

• Organization Name

  TSI CORPORATION

• Organization Department

• Organization DUNS

• Organization City

  MILFORD

• Organization State

  MA

• Organization Country

  UNITED STATES

• Organization Zip Code

  01757

• Organization District

  UNITED STATES