Claims
- 1. A method for producing hydroxyphenylpropionic acid ester represented by the structural formula, ##STR3## having a crystalline structure which, when subjected to Cu-K.sub..alpha. X-ray diffraction, shows sharp X-ray diffraction peaks at angles of diffraction, 2.theta.=4.2.degree. and 2.theta.=10.6.degree., which comprises dissolving the hydroxyphenylpropionic acid ester in
- (1) a recrystallization solvent comprising a water-soluble solvent and water in an amount of 0 to 3 times by weight based thereon, or
- (2) a recrystallization solvent comprising a C.sub.5 -C.sub.10 alicyclic hydrocarbon,
- and maintaining the resultant solution at a temperature of 40.degree. C. or higher to form crystals of the hydroxyphenylpropionic acid ester.
- 2. A method as claimed in claim 1, which further comprises cooling the solution after crystallization at a temperature of b 40.degree. C. or higher.
- 3. A method as claimed in claim 1, wherein the recrystallization solvent comprises a C.sub.1 -C.sub.3 alcohol and water in an amount of 0 to 0.4 time by weight based thereon.
- 4. A method as claimed in claim 3, wherein the recrystallization solvent comprises methanol and water in an amount of 0 to 0.3 time by weight based thereon.
- 5. A method as claimed in claim 3, wherein the recrystallization solvent comprises isopropanol and water in an amount of 0 to 0.2 time by weight based thereon.
- 6. A method as claimed in claim 1, wherein the recrystallization solvent comprises a C.sub.3 -C.sub.6 aliphatic ketone and water in an amount of 0 to 2 times by weight based thereon.
- 7. A method as claimed in claim 6, wherein the recrystallization solvent comprises acetone and water in an amount of 0 to 2 times by weight based thereon.
- 8. A method as claimed in claim 1, wherein the recrystallization solvent is cyclohexane.
- 9. A method for producing hydroxyphenylpropionic acid ester represented by the structural formula, ##STR4## having a crystalline structure which, when subjected to Cu-K.sub..alpha. X-ray diffraction, shows sharp X-ray diffraction peaks at angles of diffraction, 2.theta.=4.2.degree. and 2.theta.=10.6.degree., which comprises recrystallizing the hydroxyphenylpropionic acid ester from a recrystallization solvent comprising a water-insoluble solvent other than alicyclic or aliphatic hydrocarbons and an aliphatic hydrocarbon in an amount of 0 to less than 10 times by weight based on the water-insoluble solvent.
Priority Claims (3)
Number |
Date |
Country |
Kind |
60-136272 |
Jun 1985 |
JPX |
|
60-190457 |
Aug 1985 |
JPX |
|
61-40639 |
Feb 1986 |
JPX |
|
Parent Case Info
This application is a division of Ser. No. 868,743 filed May 30, 1986, now U.S. Pat. No. 4,769,479.
US Referenced Citations (4)
Number |
Name |
Date |
Kind |
4576734 |
Ishii et al. |
Mar 1986 |
|
4739080 |
Sasaki et al. |
Apr 1988 |
|
4745195 |
Kaneoya et al. |
May 1988 |
|
4754045 |
Sasaki et al. |
Jun 1988 |
|
Foreign Referenced Citations (2)
Number |
Date |
Country |
25826 |
Feb 1984 |
JPX |
231089 |
Dec 1984 |
JPX |
Non-Patent Literature Citations (2)
Entry |
Satoshi, Patent Abstracts of Japan, 9:104 (C-279) (1827), May 1985. |
Adeka Argus, Chemical Abstracts 101:8213w, 1984. |
Divisions (1)
|
Number |
Date |
Country |
Parent |
868743 |
May 1986 |
|