PRODUCTION OF MONOCLONAL ANTIBODIES IN TRANSGENIC MICE

Information

• Research Project
• 3507852

• ApplicationId

  3507852

• Core Project Number

  R44GM037329

• Full Project Number

  2R44GM037329-02

• Serial Number

  37329

• FOA Number

• Sub Project Id

• Project Start Date

  7/1/1986 - 38 years ago

• Project End Date

  8/31/1990 - 34 years ago

• Program Officer Name

• Budget Start Date

  9/1/1988 - 36 years ago

• Budget End Date

  8/31/1989 - 35 years ago

• Fiscal Year

  1988

• Support Year

  2

• Suffix

• Award Notice Date

  9/2/1988 - 36 years ago

Organizations

• Genetics Institute, Inc.

Monoclonal antibodies have great potential as a unique set of highly specific reagents for the prophylaxis, diagnosis and therapy of human diseases. However, a major problem encountered is the immunogenicity of these murine antibodies which limits their usefulness. In addition, human antibodies may be more efficient than mouse antibodies in mediating biological effector functions such as antibody-dependent cellular cytotoxicity in human patients. It would be a major advance to create a routine system for producing human monoclonal antibodies. The aim of our research is to generate a strain of transgenic mice that can rearrange human immunoglobulin genes, and thus, provide a functional human antibody repertoire. Mouse hybridomas could then be produced from such a mouse, using conventional techniques, that are producing human monoclonal antibodies.

IC Name

• Activity

  R44

• Administering IC

  GM

• Application Type

  2

• Direct Cost Amount

• Indirect Cost Amount

• Total Cost

• Sub Project Total Cost

• ARRA Funded

• CFDA Code

  821

• Ed Inst. Type

• Funding ICs

• Funding Mechanism

• Study Section

  SSS

• Study Section Name

• Organization Name

  GENETICS INSTITUTE, INC.

• Organization Department

• Organization DUNS

• Organization City

  CAMBRIDGE

• Organization State

  MA

• Organization Country

  UNITED STATES

• Organization Zip Code

  02140

• Organization District

  UNITED STATES