Claims
- 1. The process of purifying a crude form of 7-(D-.alpha.-amino-4-hydroxyphenylacetamido)-3-cephem-4-carboxylic acid which comprises converting said crude acid to its solid, crystalline dimethylformamide solvate containing 1.5 moles dimethylformamide per mole of said acid, isolating said solid solvate, slurrying it in nearly boiling methanol, preferably at about 50.degree. C., until the solvate dissociates, cooling the suspension and then collecting therefrom substantially pure, solid 7-(D-.alpha.-amino-4hydroxyphenylacetamido)-3-cephem-4-carboxylic acid.
- 2. Substantially pure, crystalline dimethylformamide solvate of 7-(D-.alpha.-amino-4-hydroxyphenylacetamido)-3-cephem-4-carboxylic acid containing 1.5 moles dimethylformamide per mole of said acid.
CROSS-REFERENCE TO RELATED APPLICATIONS
This application is a division of our prior copending application filed Sept. 15, 1972 as Ser. No. 289,703 and now abandoned.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
3708478 |
Chapman et al. |
Jan 1973 |
|
3867380 |
Dunn et al. |
Feb 1975 |
|
Divisions (1)
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Number |
Date |
Country |
Parent |
289703 |
Sep 1972 |
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