PRODUCTION OF PEPTIDE PHARMACEUTICALS IN PLANTS

Information

• Research Project
• 3488844

• ApplicationId

  3488844

• Core Project Number

  R43AI026959

• Full Project Number

  1R43AI026959-01

• Serial Number

  26959

• FOA Number

• Sub Project Id

• Project Start Date

  8/1/1988 - 36 years ago

• Project End Date

  1/31/1989 - 35 years ago

• Program Officer Name

• Budget Start Date

  8/1/1988 - 36 years ago

• Budget End Date

  1/31/1989 - 35 years ago

• Fiscal Year

  1988

• Support Year

  1

• Suffix

• Award Notice Date

  7/29/1988 - 36 years ago

Organizations

• DNA Plant Technology Corporation

The gene which encodes human growth hormone will be engineered for high expression in plant cells by fusions to strong promoters from plants. These chiameric genes will be transferred to plant cells via the Agrobacterium transformation system, and regenerated transgenic plants will be produced. Such plants will be assayed to determine the levels of hGH mRNA, and protein which is produced, and whether correct processing of the precursor protein has occurred, namely removal of a signal peptide, and introduction of two disulfide bonds. The approach, if successful, will provide a cost effective alternative to the large scale and economic production of protein pharmaceuticals used in mammalian health care.

IC Name

• Activity

  R43

• Administering IC

  AI

• Application Type

  1

• Direct Cost Amount

• Indirect Cost Amount

• Total Cost

• Sub Project Total Cost

• ARRA Funded

• CFDA Code

  855

• Ed Inst. Type

• Funding ICs

• Funding Mechanism

• Study Section

  SSS

• Study Section Name

• Organization Name

  DNA PLANT TECHNOLOGIES, INC.

• Organization Department

• Organization DUNS

• Organization City

  OAKLAND

• Organization State

  CA

• Organization Country

  UNITED STATES

• Organization Zip Code

  94608

• Organization District

  UNITED STATES