PRODUCTION OF THERAPEUTIC ANTISENSE OLIGONUCLEOTIDES

Information

• Research Project
• 3506115

• ApplicationId

  3506115

• Core Project Number

  R44AI028650

• Full Project Number

  2R44AI028650-02

• Serial Number

  28650

• FOA Number

• Sub Project Id

• Project Start Date

  9/30/1989 - 34 years ago

• Project End Date

  8/31/1993 - 30 years ago

• Program Officer Name

• Budget Start Date

  9/30/1991 - 32 years ago

• Budget End Date

  8/31/1992 - 31 years ago

• Fiscal Year

  1991

• Support Year

  2

• Suffix

• Award Notice Date

  9/12/1991 - 32 years ago

Organizations

• Glen Research Corporation

The use of modified antisense oligonucleotides as potential chemotherapeutics is currently progressing from in vitro studies in research labs to pharmacology studies using animal models. As yet, there exists no commercial DNA synthesizer capable of producing a variety of modified oligonucleotides on a large scale. The proposed research is designed to develop a commercial DNA synthesizer, optimized for H- phosphonate chemistry, capable of producing multigram quantities of modified oligonucleotides will be prepared. Also, techniques will be designed for the purification of these products on a pharmaceutical scale.

IC Name

• Activity

  R44

• Administering IC

  AI

• Application Type

  2

• Direct Cost Amount

• Indirect Cost Amount

• Total Cost

• Sub Project Total Cost

• ARRA Funded

• CFDA Code

  856

• Ed Inst. Type

• Funding ICs

• Funding Mechanism

• Study Section

  SSS

• Study Section Name

• Organization Name

  GLEN RESEARCH CORPORATION

• Organization Department

• Organization DUNS

• Organization City

  STERLING

• Organization State

  MD

• Organization Country

  UNITED STATES

• Organization Zip Code

  201644441

• Organization District

  UNITED STATES