Claims
- 1. A process for producing an L-phenylalanine derivative having a substituent, represented by the following general formula (1):
- 2. A process for producing an L-phenylalanine derivative having a substituent, represented by formula (1), comprising utilizing the activity of a microorganism belonging to any one of the genus Cladosporium, the genus Eurotium, the genus Thanatephorus, the genus Gonatobotryum and the genus Sporobolomyces, an ingredient containing said microorganism or a material treated with said microorganism in the presence of ammonia and a cinnamic acid derivative represented by the following formula (2):
- 3. The process for producing an L-phenylalanine derivative having a substituent as claimed in claim 1 or 2, wherein R1, R2, R3, R4 and R5 in formula (1) are each independently hydrogen, a cyano group or a hydroxy group but are not hydrogen at the same time.
- 4. The process for producing an L-phenylalanine derivative having a substituent as claimed in any one of claims 1 to 3, wherein the microorganism belonging to any one of the genus Cladosporium, the genus Eurotium, the genus Thanatephorus, the genus Gonatobotryum and the genus Sporobolomyces, which is allowed to act, is previously cultured in a culture medium containing a phenylalanine or phenylalanine derivative.
- 5. The process for producing an L-phenylalanine derivative having a substituent as claimed in any one of claims 1 to 4, wherein at least a part of ammonia is supplied in the form of a carbonate.
- 6. The process for producing an L-phenylalanine derivative having a substituent as claimed in any one of claims 1 to 5, wherein the pH is adjusted using carbon dioxide.
- 7. The process for producing an L-phenylalanine derivative having a substituent as claimed in any one of claims 1 to 6, wherein at least a part of the obtained L-phenylalanine derivative having a substituent is recovered as an ammonium salt.
- 8. The process for producing an L-phenylalanine derivative having a substituent as claimed in any one of claims 1 to 7, wherein at least a part of the obtained L-phenylalanine derivative having a substituent is recovered as a carbonate.
- 9. The process for producing an L-phenylalanine derivative having a substituent as claimed in any one of claims 2 to 8, wherein the reaction solution has a cinnamic acid derivative content of 5% by mass or less.
- 10. The process for producing an L-phenylalanine derivative having a substituent as claimed in any one of claims 1 to 9, wherein the L-phenylalanine derivative having a substituent is 3-cyano-L-phenylalanine.
- 11. The process for producing an L-phenylalanine derivative having a substituent as claimed in any one of claims 1 to 9, wherein the L-phenylalanine derivative having a substituent is 4-cyano-L-phenylalanine.
- 12. The process for producing an L-phenylalanine derivative having a substituent as claimed in any one of claims 1 to 9, wherein the L-phenylalanine derivative having a substituent is 3-hydroxy-L-phenylalanine.
- 13. The process for producing an L-phenylalanine derivative having a substituent as claimed in any one of claims 1 to 9, wherein the L-phenylalanine derivative having a substituent is 4-hydroxy-L-phenylalanine.
- 14. The process for producing an L-phenylalanine derivative having a substituent as claimed in any one of claims 1 to 9, wherein the L-phenylalanine derivative having a substituent is 3,4-dihydroxy-L-phenylalanine.
- 15. The process for producing an L-phenylalanine derivative having a substituent as claimed in any one of claims 1 to 14, wherein the microorganism used is any one of Cladosporium colocasiae, Eurotium chevalieri, Thanatephorus cucumeris, Gonatobotryum apiculatum and Sporobolomyces roseus.
- 16. The process for producing an L-phenylalanine derivative having a substituent as claimed in any one of claims 1 to 14, wherein the microorganism used is any one of Cladosporium colocasiae IFO 6698, Eurotium chevalieri IFO 4090, Thanatephorus cucumeris IFO 6254, Gonatobotryum apiculatum IFO 9098 and Sporobolomyces roseus IFO 1040.
- 17. An L-phenylalanine derivative having a substituent, represented by the following formula (1):
- 18. The L-phenylalanine derivative having a substituent as claimed in claim 17, wherein R1, R2, R3, R4 and R5 are each independently hydrogen, a cyano group or a hydroxy group but are not hydrogen at the same time.
- 19. The L-phenylalanine derivative having a substituent as claimed in claim 17, wherein the L-phenylalanine derivative having a substituent is 4-cyano-L-phenylalanine.
- 20. The L-phenylalanine derivative having a substituent as claimed in claim 17, wherein the L-phenylalanine derivative having a substituent is 3-hydroxy-L-phenylalanine.
- 21. The L-phenylalanine derivative having a substituent as claimed in claim 17, wherein the L-phenylalanine derivative having a substituent is 4-hydroxy-L-phenylalanine.
- 22. The L-phenylalanine derivative having a substituent as claimed in claim 17, wherein the L-phenylalanine derivative having a substituent is 3,4-dihydroxy-L-phenylalanine.
Priority Claims (2)
Number |
Date |
Country |
Kind |
2000-249358 |
Aug 2000 |
JP |
|
2001-116892 |
Apr 2001 |
JP |
|
CROSS REFERENCE TO RELATED APPLICATIONS
[0001] This application is an application filed under 35 U.S.C. §111(a) claiming benefit pursuant to 35 U.S.C. §119(e)(1) of the filing dates of U.S. Provisional Application 60/256,908 filed Dec. 21, 2000 and U.S. Provisional Application 60/285,246 filed Apr. 23, 2001 pursuant to 35 U.S.C. §111(b).
PCT Information
Filing Document |
Filing Date |
Country |
Kind |
PCT/JP01/07156 |
8/21/2001 |
WO |
|